In the early days of treatment, you may still sometimes feel unwell. Careful physical examination by your doctor is important to spot and distinguish symptoms. But it might not be easy for your doctor to identify the underlying cause of new symptoms. They might be caused by HIV itself, an opportunistic infection, IRIS, a drug side effect or a disease unrelated to HIV.
Drug side effects are a possibility. Unfortunately, taking multiple medications makes side effects more likely. There is also evidence that some side effects can be more troubling for people with low CD4 counts. Looking ahead to when your HIV is under better control, your treatment should become more tolerable.