HIV MedicationsTriumeq

Triumeq for HIV Treatment: Everything You Need to Know

illustration of larger-than-life Triumeq bottle alongside a person holding a massive Triumeq pill
Lily Fulop

    Frequently Asked QuestionsTriumeq

    What is Triumeq used for?

    Triumeq is a complete single-tablet regimen (STR) for the treatment of HIV. It was approved for use by the Food and Drug Administration (FDA) in 2014.

    How often is Triumeq taken?

    Triumeq is normally taken by mouth once a day, with no food or timing restrictions (i.e., it can be taken any time of day). The important part is striving to take it around the same time every day.

    Does Triumeq have any side effects I should worry about?

    Triumeq has the potential to cause mood issues and sleep disturbances. There have also been concerns about a study highlighting a possible link between the DTG in Triumeq and neural tube defects (birth defects of the brain and spinal cord that cause conditions like spina bifida) in infants born to women using the drug at the time of conception. New data from two studies, however, refuted this link; DTG continues to be a preferred treatment option during pregnancy. The abacavir in Triumeq has been associated with a higher risk of developing heart disease in some studies; other studies have not found this association.

    What are the drugs in Triumeq?

    It’s a pill made of three medications: abacavir (ABC), lamivudine (3TC), and dolutegravir (DTG).

    • ABC and 3TC are both in the class of drugs called “nucleoside reverse transcriptase inhibitors” (NRTI), which block HIV from making copies of itself early in its life cycle.
    • DTG is in the class of drugs called “integrase strand transfer inhibitors” (INSTI), which stop HIV from making copies of itself later in its life cycle.

    Are there concerns about allergic reactions to any of the medications in Triumeq?

    Triumeq contains the medication abacavir (ABC), which has been associated with a rare, potentially severe, allergic (hypersensitivity) reaction among people who are genetically predisposed to it. Speak to your medical provider if you are considering starting this medication, as you will need some bloodwork done to make sure you are not at risk for this allergic reaction.

    David Malebranche, M.D., M.P.H.

    David Malebranche, M.D., M.P.H.

    David Malebranche, M.D., M.P.H., is a black same-gender-loving educator, author, activist, and internal medicine physician. He co-hosts the YouTube series 'Revolutionary Health' as part of The Counter Narrative Project and also appears on the #AskTheHIVDoc video series.