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The Effects of Hydroxyurea or Placebo Combined with Efavirenz, Didanosine, and Stavudine in Treatment of Naive and Experienced Patients: Preliminary 24-Week Results From the Third Study

The effects of hydroxyurea or placebo combined with efavirenz, didanosine, and stavudine in treatment of naive and experienced patients: preliminary 24-week results from the third study (WeOrB603) Authored by R. Murphy, C. Katlama, B. Autran, E...

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Bonanza: With Demand for Treatment Breaks at Record Level, Market for Tiny, Uninterpretable Studies Flourishes

Diverse Definitions

At least eighteen studies and speeches presented at the Seventh Retrovirus Conference included discussions related to treatment interruptions (TIs) and structured treatment interruptions (STIs) in various HIV infected populations...

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It Takes Two, Maybe

Initially used in salvage regimens, dual protease inhibitor therapy is now increasingly used earlier in treatment. (For discussions of dual protease inhibitors in salvage therapy, see Treatment Issues, "Salvage Therapy: Still More Intuition Than Data...

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Selected Highlights from the 7th CROI: Studies of Switching Therapy

Several studies examined the effects on fat redistribution and metabolic changes after switching from a PI-based HAART combination to one without a PI. Overall, the results were mixed, with some possible trends towards some improvements in certain st...

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Turn on Your Body -- Mobilize the Immune System

Along with the search for better, more powerful antivirals with fewer side effects, there are ongoing efforts to try to eradicate HIV and to get the body's immune system to control HIV without the constant use of antivirals. On this front, we have ba...

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Pulsed Therapy and Structured Interruptions of Treatment

Research has begun on two new strategies for long-term treatment of HIV disease. Although both theories involve taking people off treatment in some way, they have different goals and expectations. These two strategies are known as pulsed therapy and ...

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Intermittent HIV Therapy

Temporary discontinuation of antiretroviral therapy under the guidance of a health care provider is sometimes necessary due to severe side effects or other quality of life issues. Because viral loads generally rebound rapidly, such discontinuations -...

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Snapshots of the Literature

Comparison of Three Regimens for Treatment of Mild to Moderate Pneumocystis carinii Pneumonia in Patients with AIDS [Safrin S, et al. Ann Intern Med 1996;124:792]: This is ACTG trial 108 comparing trimethoprim-sulfamethoxazole, dapsone-trimethoprim...