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Treatment Interruption: A Risky but Essential Step in Cure Research Img

Treatment Interruption: A Risky but Essential Step in Cure Research

If there is ever to be an HIV cure, first there must be people who are willing to interrupt their antiretroviral therapy. It's a risky maneuver, but utterly essential to test whether an experimental intervention is effective.

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HIV Causes Accelerated Aging: Has AIDS Become Acquired Inflammation Disease Syndrome?

I don't plan to grow old gracefully. I plan to have facelifts until my ears meet.

-- Rita Rudner

Inflammation is the hottest topic in HIV/AIDS research. We've known for many years that, left untreated, HIV disease produces widespread inflammation. ...

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Giraffes and HIV: Treatment Interruptions With a Twist

Editor's Note: Dr. Zalski is filling in for Dr. Daniel S. Berger for this issue

With the recent New Year came the usual resolutions, including improving one's fitness. We're all familiar with the new crowds at the health clubs that time of year th...

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Pittsburgh: Grant to Fund AIDS Outreach in Black Neighborhoods

The Pittsburgh AIDS Task Force is using a $148,000 grant from the U.S. Office of Minority Health to assist grassroots organizations battling HIV/AIDS in the black community.

The task force will use the grant funds to build partnerships with communit...

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SMART Study: Background, Concepts, and Design

Sharon is a 28-year-old African American whose HIV infection was diagnosed 9 months ago. Of three determinations, her average CD4 T cell count has been 489 cells/mm3; average viral load, 17,500 copies/mL. Before undertaking a regimen of highly active...

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2000: A Year of Endings and Beginnings

2000 finally saw the end of "Hit Hard, Hit Early." People had been questioning the early use of antiretrovirals for some time, but when Dr. Anthony Fauci, head of NIAID, gave a plenary speech at the Durban AIDS conference and said, ". . . prolonged c...

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Structured Treatment Interruption: Important Controlled Trial in Monkeys

The first randomized, controlled study of structured treatment interruption (STI) found that monkeys on a three-week-on/three-week-off treatment schedule controlled the virus about as well as those which were on continuous therapy (and therefore rece...

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Report on the First International Acute HIV Infection Conference

Arlington, VA October 16 and 17, 2000

Acute Infection Definitions Challenges for Identifying Acute Infection Defining HIV-specific Immunity Clinical Trials of Acute Infection Transmission of Drug-resistant HIV Concluding Observations...

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Finding the Right Use for Treatment Interruptions: STI May Work for People Who Begin HAART During Primary HIV Infection

The newly developed strategy of using interruptions in therapy, (known as "structured therapy interruptions," or STI) to stimulate HIV-specific immune responses has shown promise when used in people who began HAART immediately after becoming infected...

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New Developments in Affordable Antiretroviral Therapy: Several Studies Examine Intermittent Treatment

Drug Interruptions, Holidays and Pauses: an overview of outcomes. A randomized, controlled trial of intermittent versus continuous highly active antiretroviral therapy (HAART) (Lb0r11) Authored by M. Dybul, C. Yoder, M. Belson, T.-W. Chun, C. H...