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Access to Efavirenz and Amprenavir

As reported in last month's TI, efavirenz (Sustiva), the newly approved nonnucleoside analog from DuPont, is embroiled in a dispute over its exceptionally high price. DuPont's negotiations with various state AIDS Drug Assistance Programs over efavire...

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FDA Approves New Drug to Treat HIV, AIDS

The Food and Drug Administration has approved efavirenz, a new drug, to treat HIV and AIDS in children and adults. Efavirenz, in combination with other antiretroviral agents, was approved to treat HIV-1 infection after 24-week studies showed it to be...

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What Price Efavirenz?

DuPont Pharmaceutical's new drug efavirenz (Sustiva) has enjoyed a favored position among treatment activists, offering both high levels of antiviral activity and a simplified dosing regimen. The company has worked to build a harmonious relationship ...

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More on Efavirenz

Efavirenz (SUSTIVA, formerly known and still thought of as DMP-266) received a lot of attention. See the DMP266-006 study for an important head to head comparison of AZT/3TC efavirenz, AZT/3TC indinavir vs. efavirenz indinavir. One of the limitations...

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Efavirenz Pregnancy Warning

The Division of AIDS Services (DAIDS) has issued a pregnancy safety alert to its trial sites regarding efavirenz (also known as DMP 266 and Sustiva) based on information provided by the drug's manufacturer, DuPont Merck. A study conducted by the comp...

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DMP 266 Now Available

DuPont Merck's potent new non-nucleoside reverse transcriptase inhibitor DMP 266, now called Sustiva or efavirenz, will be made available in October through a limited expanded access program. To be eligible for the program, individuals must have had ...