Managing HIV Drug Resistance

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Proviral DNA(RTI,PI,Int Inhib) Not Performed

Recently, my doctor ordered this resistance test. When the results came back, it stated that the test could not be performed, probably because sufficient DNA could not be collected. A repeat test was performed and the same non-results came back. I ha...

By Mark Holodniy, M.D.

Non-Nucleoside Resistance and CCR5 Gene Therapies

The version of the virus I acquired had already developed resistance to non-nucleosides. With many of the gene editing therapies in the pipeline targeting the CCR5 gene, I'm wondering if my variant requires that gene to infect a cell?

By Mark Holodniy, M.D.

Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load

Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load Hello Dr. Holodniy! I was tested negative in May 2018 and infected in early June of 2018. When I was first diagnosed HIV-1 in mid July 2018, my viral loa...

By Mark Holodniy, M.D.

(Few Questions Added) Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load

(Few Questions Added) Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load Hello Dr. Holodniy! I was tested negative in May 2018 and infected in early June of 2018 (I only gave unprotected oral sex and recei...

By Mark Holodniy, M.D.

Recently diagnosed, starting therapy

Hi. I was just recently diagnosed. I am a healthy, 28 y/o male. I was prescribed Biktarvy by my ID. And he ordered in my genotype test. I understand genotype test checks for drug resistance. Should I wait for the test results before I start taking Bi...

By Mark Holodniy, M.D.

HIV Drug Resistance

Get basic information about HIV drug resistance -- what it is, what causes it, testing for it, and how to prevent it from developing.

By The Well Project

IS there a simpler regimen?

I'm taking the following: Prezista 600 mg 2x/day, Norvir 100mg 2x/day, Tivicay 50mg 2x/day, Descovy 1x/day, and Intelence 200 mg 2x/day. This seems like a lot of medicine! Especially b/c the only drug I'm mostly resistant to in this combo is the FTC ...

By Benjamin Young, M.D., Ph.D.

Please answer, I need to know what to do before renewing my annual ARV prescription

Hello, I was diagnosed in HIV1 acute infection in May 2017 with a viral load of 10 millions. I started taking Genvoya since then. Actually, 9 months after starting the treatment, My viral load is fluctuating between <40 and 70 ... plus one month afte...

By Benjamin Young, M.D., Ph.D.

Failing? What should I do?

Hi Dr. Holodiny I switched from Tiv/Truv to Tiv/Des in Aug 2016. Before switching, VL always (21 years) < 48. But 4 mos. later (Dec 2016): 105. Jan 2017: 74. Mar: 102. May: 103. Aug: 50. Dec: 303. I never miss doses. The switch is the only var...

By Mark Holodniy, M.D.

Is it ok to take Valtrex and stribild?

Is it ok to take stribild and Valtrex ? Im a lil nervous

By Benjamin Young, M.D., Ph.D.