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Conference Coverage: 3rd International Workshop on Salvage Therapy for HIV Infection

This report includes highlights from the 3rd International Workshop on Salvage Therapy for HIV Infection held April 12-14, 2000, in Chicago, and the 10th International Symposium on Viral Hepatitis and Liver Disease held April 9-13, 2000, in Atlanta. ...

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Genotypic and Phenotypic Resistance Tests -- What Is the Difference?

HIV drug resistance occurs when the virus is able to resist the drugs ability to suppress or limit its reproduction. There are currently two tests used to measure for drug resistance. One kind of test is called a "genotypic" test, the other is called...

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Multdrug-Resistant HIV and Primary Infection: A New Threat to At-Risk Individuals, and a New Challenge for Care Providers

The next wave of the HIV epidemic has begun to roll over us. It has already hit the communities at highest risk -- men who have sex with men and intravenous-drug users living in areas where multi-drug antiretroviral therapy is now the standard of car...

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Drug-Specific Resistance

In a time of rising HIV drug resistance and increasing treatment choices, the use of an HIV drug resistance test may help people living with HIV to make optimal therapeutic choices and avoid treatment failure caused by drug resistance.

While combina...

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Chemokines and HIV Coreceptors: Opening Doors to New Anti-HIV Strategies

NIAID's sustained commitment to basic research continues to yield breakthroughs that, although still in their early stages, are likely to culminate in significant medical benefits. The story of chemokines and HIV coreceptors is an example of how year...

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The AIDS Race

A milliliter is a tiny amount of fluid, barely a drop. But in 1994, more than 650,000 AIDS viruses swarmed in every milliliter of Dawn Averitt's blood, seeking out and destroying her few surviving immune-system T cells. Desperate, she entered a clini...

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The Multiple Nucleoside Analogue Resistance Mutations Confer Cross-Resistance to Abacavir

In this collaborative European study the authors began with the observation that the mutation Q151M, together with other mutations that code on 62, 68, 75, 77 and 116 of the HIV I RT gene response for high level resistance against the NRTI's. Abacavi...

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The Virus Fights Back

GENEVA -- At least three separate research teams here at the 12th World AIDS Conference announced that strains of HIV resistant to many drugs, including the powerful protease inhibitors, have been transmitted from one person to another. None of these...

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Viral Resistance: How It May Affect Treatment Options

Although the use of triple and quadruple drug combinations for HIV infection has dramatically changed the course of the disease in many persons with HIV/AIDS in the last two years, the appearance of new therapeutic approaches has also created new cha...

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How Drug Resistance Develops

As Dr. Paul Volberding, the editor-in-chief of HIV Newsline, observes in his editorial in this issue, "The technological and therapeutic advances of recent years have radically altered our approach to treating HIV infection, and they have dramaticall...