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HIV Treatment and Medical Care

Managing HIV Drug Resistance

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Is Your HIV Viral Load Normal?

An expert HIV doctor explains viral load testing, what "undetectable" and "unquantifiable" really mean, and how to make sense of your latest numbers.

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Proviral DNA(RTI,PI,Int Inhib) Not Performed

Recently, my doctor ordered this resistance test. When the results came back, it stated that the test could not be performed, probably because sufficient DNA could not be collected. A repeat test was performed and the same non-results came back. I ha...

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Non-Nucleoside Resistance and CCR5 Gene Therapies

The version of the virus I acquired had already developed resistance to non-nucleosides. With many of the gene editing therapies in the pipeline targeting the CCR5 gene, I'm wondering if my variant requires that gene to infect a cell?

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Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load

Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load Hello Dr. Holodniy! I was tested negative in May 2018 and infected in early June of 2018. When I was first diagnosed HIV-1 in mid July 2018, my viral loa...

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(Few Questions Added) Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load

(Few Questions Added) Twice Lab Failed to Perform Genotype Drug Resistant Testing Even Though I Had Enough Viral Load Hello Dr. Holodniy! I was tested negative in May 2018 and infected in early June of 2018 (I only gave unprotected oral sex and recei...

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HIV Drug Resistance

Get basic information about HIV drug resistance -- what it is, what causes it, testing for it, and how to prevent it from developing.

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IS there a simpler regimen?

I'm taking the following: Prezista 600 mg 2x/day, Norvir 100mg 2x/day, Tivicay 50mg 2x/day, Descovy 1x/day, and Intelence 200 mg 2x/day. This seems like a lot of medicine! Especially b/c the only drug I'm mostly resistant to in this combo is the FTC ...

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Failing? What should I do?

Hi Dr. Holodiny I switched from Tiv/Truv to Tiv/Des in Aug 2016. Before switching, VL always (21 years) < 48. But 4 mos. later (Dec 2016): 105. Jan 2017: 74. Mar: 102. May: 103. Aug: 50. Dec: 303. I never miss doses. The switch is the only var...

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Taking Genvoya every other day.

I live outside the US and cant afford genvoya monthly. How dangerous scientifically speaking would it be to tak Genvoya every other day. I have to pay cash and It is very expensive. Thankyou Saki

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Drug Resistance

Key PointsAs HIV multiplies in the body, the virus sometimes mutates (changes form) and produces variations of itself. Variations of HIV that develop while a person is taking HIV medicines can lead to drug-resistant strains of HIV.With drug resistanc...