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Viral and Immunologic Examination of HIV-I-Infected Persistently Seronegative Persons

In this study the authors observed that in detecting HIV I infection the modalities used were based on serological testing for antibodies. There are nine commercial licensed EIA type kits and confirmation is usually done using Western blot or IFA. Th...

HIV-1 Latent Reservoirs Exist in the Semen of HIV-Infected Men

This study provides further data to suggest that despite non-detectable plasma HIV-1 RNA levels, that replication competent proviral DNA exists in seminal fluid. Seven patients on HAART whose plasma and seminal RNA levels were below 50 copies/mL were...

Immune-Based Therapies

Slowly but surely, immune-based therapies (IBTs) are beginning to steal some of the spotlight away from HAART. Given what is now known about the limitations of HAART, many researchers are now focusing on some of the impressive research involving IBTs...

HIV Resurrection

The overarching AIDS image from this year's Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC, held in Toronto from September 28 to October 1) was a huge slide projection of a cell bursting forth with HIV displayed during Robert...

HIV in Genital Secretions -- Part 1

A Summary of Three Presentations: Frequent Recovery Of Replication Competent HIV From Genital Herpes Simplex Virus Lesions in HIV-Infected Persons Presenter: Tim Schacker, University of Washington, Seattle, WA. Correlation of Cell-free and Cell-ass...

HIV in Genital Secretions -- Part 2

A Summary of Four Presentations: High Levels of HIV-1 in Semen and Blood in Men in Malawi Presenter: Joe Eron, University of North Carolina, Chapel Hill High Viral Load in Semen of HIV-1 Infected Men at All Stages of Disease and Reduction by Antire...

Long-Awaited Research Paper Takes on the Viral Diversity Threshold, Cannibalistic CTLs and NSI-to-SI Switch

AIDS research is only fifteen years old. A few years ago, the field was largely dominated by and comprised of scientists who had moved from other areas of inquiry to colonize a new metier for investigation. Like colonists before them, many had made t...

Report on Drug Development from the HIV Immune-based Therapies Workshop

The Clinical Immunology Society's 2nd HIV Immune-based Therapies Workshop was held in Baltimore on January 27-29. Attendance seemed a little down compared to last year's meeting, which may simply reflect the increased representation of issues pertain...

The Immune System: A Primer

This excerpt is reprinted by permission of Penguin Books USA, Inc.from The Immune Power Personality by Henry Dreher As a guide to the research detailed in this book, I offer a primer on the basic functions of our immune system--its organs, cells, ce...

Basic Research on HIV Infection: A Report From the Front

Contents:IntroductionMaterials and MethodsPart I: Scientific IssuesCorrelates of Immunity"In Vivo Veritas"The Pathology of HIV InfectionEvents in the Viral Life Cycle:TransmissionThe Viral Life CycleEnvelope Structure and FunctionMechanisms of Viral ...