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The $4 Question

Each day, 1,600 infants are infected with HIV. While perinatal transmission has been reduced to only a few hundred cases a year in the US through the use of a lengthy course of AZT, the regimen, which costs $800, is far out of the reach of all but a ...

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High HIV RNA Levels Major Risk Factor for Mother-to-Child HIV Transmission

Two studies supported by the National Institutes of Health (NIH) provide compelling evidence that the amount of HIV in a pregnant woman's blood, known as the maternal HIV viral load, is the prime risk factor for transmitting the virus to her baby.


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Vertical Transmission

Ever since the results of the ACTG 076 trial were published in 1993, AZT (Retrovir®) has been administered to HIV-infected pregnant women and their infants to reduce the rate of mother-to-child transmission. In the era of HAART, many doctors and scie...

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Perinatal and Postnatal Transmission* of HIV Infection


Numbers and Proportions Infants Affected; Populations at Risk Maternal Exposure Categories Recent Trends in Treatment and Transmission Rates Natural History Treatment and Prevention: Treatment of the Woman During Pregnancy and Ot...

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Problem Pregnancy

Many people think it's the single greatest victory in AIDS: Giving the drug AZT to pregnant women halves the chance that they will pass on the virus to their newborns. It's being hailed as a vaccine for babies -- and scientists, industry leaders, and...

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Success in Implementing Public Health Service Guidelines to Reduce Perinatal Transmission of HIV -- Louisiana, Michigan, New Jersey, and South Carolina, 1993, 1995, and 1996

In 1994, the Public Health Service (PHS) published guidelines for zidovudine (ZDV) use to reduce perinatal transmission of human immunodeficiency virus (HIV) (1), and in 1995 published guidelines for HIV counseling and voluntary testing of pregnant w...

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Working to Improve Pregnancy Outcomes

Research to eliminate mother-to-child HIV transmission (vertical transmission) was one of the highpoints at the 12th World AIDS Conference. Several very encouraging reports on the effectiveness of Cesarean sections (C-sections) were presented. Severa...

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Highly Active Therapy in Pregnancy May Lower Transmission Rates More Than AZT Alone

Session 459/12151: Control of maternal HIV-1 disease during pregnancy Poster Session 32453: Safety of combined therapies in pregnancy

The new guidelines for antiviral therapy suggest that we should consider the best antiviral therapy for a pregn...

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Status of Perinatal HIV Prevention

During the early 1990s, before perinatal preventive treatments were available, an estimated 1,000-2,000 infants were born with HIV infection each year in the United States. Today, the U.S. has seen dramatic reductions in mother-to-child, or perinatal...

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Efavirenz Pregnancy Warning

The Division of AIDS Services (DAIDS) has issued a pregnancy safety alert to its trial sites regarding efavirenz (also known as DMP 266 and Sustiva) based on information provided by the drug's manufacturer, DuPont Merck. A study conducted by the comp...