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How to Use Condoms Correctly

Condoms are like cars: If you have an accident with one, the cause is almost certainly operator error, not mechanical failure. Indeed, the estimated failure rate of latex condoms is between 2% and 5% -- and when a condom does tear during intercourse,...

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Where the Rubber Meets the Road: Tips for Using Condoms

When used correctly, latex and polyurethane condoms stop the spread of HIV almost 100% of the time. Condoms are like cars: If you have an accident with one, the cause is almost certainly operator error, not mechanical failure. The estimated failure r...

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Optimal Medical Management: Entering the Era of Truly Individualized Antiretroviral Therapy

Over the past few years, there has been much speculation and debate about the potential role of drug-level monitoring in the optimal medical management of individuals with HIV infection. In its simplest form, so-called therapeutic drug monitoring, or...

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Optimal Medical Management: Clinical Considerations in Therapeutic Drug Monitoring

Prior to ordering either a drug-level test or a phenotype for any patient, clinicians should evaluate the following

Patient Adherence

Both TDM and phenotyping are predicated on the assumption that the patient is taking all of his doses of all of hi...

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Managing the Adverse Effects of Antiretroviral Therapy

Hypersensitivity Reactions Gastrointestinal Effects of Antiretroviral Therapy Pancreatitis Hematologic Effects of Therapy Renal Effects Peripheral Nervous System Effects Central Nervous System Effects Metabolic And Endocrine Effects ...

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Suffer the Children

When Incarnation Children's Center, a pediatric AIDS facility that serves one of New York City's most blighted neighborhoods, Washington Heights, opened in 1989, photographer Claire Yaffa was there. "She simply appeared on my doorstep," says Dr. Step...

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OI Update: Toxoplasmosis

Toxoplasmosis is one of the most common opportunistic infections seen in patients with advanced HIV disease, especially in areas of the world where the rate of toxoplasma infection is high. It is also one of the most easily prevented OIs. Even before...

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Personal Stories

The Toughest Decision I Ever Made

My name is Rebecca, and I am HIV-positive. When I tested positive in 1990, the first thought that came into my head was "Does this mean that I can't have a baby?" I quickly turned my thoughts to other concerns: How long was I likely to live? Had I in...

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A New Approach to Therapy

The good news is that we are now witnessing the first decrease in HIV/AIDS mortality since the inception of the epidemic seventeen years ago.(1, 2) The chief cause of this turnaround is the ability of powerful new multidrug antiretroviral regimens to...

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Protease Inhibitor Resistance and Therapy

When used as part of a three-drug regimen, protease inhibitor therapy typically results in durable and potent suppression of viral replication. This has led to widespread optimism that HIV infection may eventually become a chronic, manageable disease...