I just came across an article that mentions the effect of Vit B12 (methyl-cobalamine) supplementation on decreasing total CD8 count and thus, helping normalize CD4/CD8 ratios. Apparently, Vit B12 deficiency is quite common among HIV-ers. What is your take on this? What dose of Vit B12 or other Vit B's should be take (if any)?
Thank you as usual for you knowledge and tremendous help.
B-12 deficiency is not that common unless the person is malnurished or is not consuming enough B-12 rich foods. I do not know where you read the info on B-12 and CD8 cell count. I have not found any papers on the subject.
A lack of vitamin B12 occurs when the body does not get or is unable to absorb the amount of vitamin that the body needs.
People who follow a vegetarian or vegan diet should try to eat vitamin B12-fortified foods or talk to their health care provider about taking B12 supplements.
People who have had gastrointestinal surgery, such as weight loss surgery, lose the ability to absorb vitamin B12.
People who have digestive disorders, such as Celiac or Chron's Disease, may not absorb enough vitamin B12.
Metformin, proton pump inhibitors (PPIs), and alcohol can decrease B12 absorption.
Low levels of B12 can cause:
Anemia and pernicious anemia
Loss of balance
Numbness or tingling in the arms and legs
Supplementing vitamin B12 can be beneficial if you have a difficult time consistently including foods in your diet that are rich in B12, or if you have a condition (or high activity level) which can deplete B12 from your body. Not only is vitamin B12 essential in proper brain function, but it is also needed for the process of converting carbohydrates, fats, and proteins from food into energy. Supplementing vitamin B12 is very cheap and easy. No toxicity has been reported since this vitamin is water soluble and it is excreted by the kidneys if not used by the body. There are two common types of vitamin B12 which are marketed, Cyanocobalamin and Methylcobalamin.
Foods high in Vitamin B12 include shellfish, liver, fish, crab, fortified cereals, red meat, low fat dairy, cheese, and eggs.
You can ask your doctor to have your blood level of B-12 measured in your blood.