You read that two poz dudes who bareback actually improve their immune functioning. WHAT? Where did you read such nonsense, the Journal of Irreproducible Results? Is it true? No, of course not! Silly boy!
As for your question about two men with the "exact same HIV strain," that is really very hypothetical, because HIV evolves very quickly and quite differently in different hosts. HIV can replicate billions of times each day and consequently small genetic changes occur quite rapidly. So even though one guy may have transmitted HIV to another, that strain of HIV may (and often does) evolve very differently in the two men. If you think about it, this make sense. If the virus was exactly the same, everyone's clinical course would be very similar, and we know that's not the case, right?
There are also other reasons two poz guys should not play Brokeback Mountain. See below.
Sex between 2 poz guys (SUPER INFECTION, 2010) (SEX BETWEEN TWO HIV POSITIVE PARTNERS, 2010) Feb 17, 2010
I've been asked by another poz guy to have bareback sex. I don't know the facts. One would think that since we're both poz it doesn't matter, but I've heard otherwise. I'm the top, but I don't know if that makes any difference. thanks.
Response from Dr. Frascino
You've heard correctly! It does indeed matter! Poz-on-poz couplings are at risk for superinfection (acquiring a different strain of the virus) and for other STDs that could make your HIV disease flare out of control. My advice is always to cover your stump before you hump!
By the way this question has become a QTND (question that never dies). See below.
Superinfection by Positive Partner Jan 8, 2010
My partner and I are both positive. However, I have been positive for 1 year and he's been positive for 6 years. I am undetectable with cd4 of 540 (taking Truvada and Isentress, although my kidney levels have spiked a little, my doctor is concerned that Truvada could be the culprit). He told me he was undetectable, yet he's been on meds off and on. Am I in danger of being superinfected if we have unprotected insertive sex? What are the chances of me contracting a virus more dangerous than the K103N virus I have been diagnosed with?
Response from Dr. Frascino
I've discussed this topic many times in this forum. Consequently I'll only respond briefly and then refer you to the archives for a more detailed response if needed, OK?
Commando-Rambo-barebacking is risky for a number of reasons:
Superinfection (dual infection) is indeed a possibility. Exactly how often this occurs is difficult to determine. It seems to be more common in early HIV disease. This risk, great or small, remains easily preventable by using condoms for penetrative sex. The consequences of a superinfection can be catastrophic. Why risk it?
Other STDs are out there and cannot only make life miserable, but can also result in a spike in HIV viral replication and loss of viral control.
Bottom line: Protect your bottom (and your top).
Be well. Stay well.
Poz bottom with poz top issues Jan 21, 2010
Is there such a thing as "worse" infection if a poz bottom has unprotected sex with a poz top? Or is positive just positive?
Response from Dr. Frascino
It's possible to acquire an additional more virulent (aggressive and dangerous) strain of the virus. This is often called a superinfection. You can read all about it in the archives. I'll repost below a sample of what you can find in the archives of this forum.
Latex (or polyurethane) condoms for penetrative sex are recommended, even if both partners are HIV positive, not only to prevent superinfection, but also to prevent other STDs that could exacerbate an HIV infection.
Superinfection Real? Apr 18, 2009
I'm positive, healthy, on meds, undetectable, 765+ tcell, 38%, etc etc.
But when I fool around with a trick, even if he's positive, I've always asked him to wear a condom. They always look shocked that I asked if we're both poz. Besides the reasons of other STD's, I have heard you could get another strain of the hiv virus from someone else and possibly become more resistant to other hiv drugs.
With that said... I got into a discussion about this with a trick, and he stated that the whole superinfection situation is more a theory than reality. Something about if a different strain of the virus entered by bloodstream, it would be killed off by my meds before it got a chance to infect. He threw some other techno-babble in there, but he appeared to think he knew what he was talking about.
So I was wondering if you can give me a little background on the whole barebacking with poz guys and the risks it carries related to HIV. Is superinfection really only a theory?
It's really quite amazing how many poz guys bareback. I haven't met one yet where I haven't had to have this conversation. It appears to be a very poorly misunderstood subject.
Response from Dr. Frascino
"Can I give you a little background on the whole barebacking with poz guys and the risks it carries related to HIV?" Sure. See below.
Is superinfection really only a theory? Nope. See below.
As for poz guys understanding this subject, I would agree with either "poorly understood" or "misunderstood." However, "poorly misunderstood," no, that is not correct. That sounds like a double negative George Bushism.
Undetectable Viral Load Infection and Superinfection (FINDINGS SUGGEST HIV CAN BE TRANSMITTED FROM MSM WITH UNDETECTABLE VIRAL LOAD 2009) (SUPERINFECTION, 2009) Apr 7, 2009
Thanks for your comments and information about the possibility that people with undetectable viral might be able to infect HIV negative people and contribute to HIV superinfection, but is there any research revealing the actual numbers of such infections and the probability of being infected under such circumstances and being infected with a superinfection?
Response from Dr. Frascino
No, we do not have reliable information as to how often this phenomenon occurs. As you can probably imagine it is quite challenging to conclusively prove that a particular strain of HIV was transmitted to an already infected individual. This requires specialized, labor-intensive and highly expensive laboratory analysis. What has been conclusively proven is that HIVers with an undetectable HIV plasma viral load can transmit their virus to others. Generally speaking it is felt that superinfections (dual infections) are not frequent and are most likely to occur early in the course of the disease. However, even if the frequency is confirmed to be low, it's still a risk I certainly would neither recommend nor personally take.
Barebacking as a bottom (FINDINGS SUGGEST HIV CAN BE TRANSMITTED FROM MSM WITH UNDETECTABLE VIRAL LOAD 2009) (SUPERINFECTION, 2009) Mar 28, 2009
recently alot of bareback videos have come on the market which i love watching. i am poz and was always told dont bareback you can change your strain and become resistance to your current meds, "atripla" by the way and undetectable. but how can porn stars and even close friends of mine that are poz continue to bareback as a bottom and have the top ejaculate in them and have for years and my friends say it has never interferred with there viral loads and they have stayed undetectable and some of my friends have multiple partners at bathouses and they are still fine this perplexes me i read the recent article following poz couples that are undetectable and how they did not get a super infection, so what is your take on all this? now keep in mind yes a couple of my close friends bareback but not without have gotten other std's but never a increase in viral load or med failure. recently i was in L.A and went to a bathouse and it seemed everybody was barebacking and not only did this place offer hiv testing but also viral load testing and it said to see if you have been recently re-infected again. huh? whats the deal? keep in mind i am 37 and only been poz for 16months so a little naive to it all.. thanks love, love, love you and all your words of wisdom and knowledge of the matter...
Response from Dr. Frascino
Your friends are playing sexual Russian roulette. I'm sure they are happy to share their experiences of playing Brokeback Mountain with HIV-positive cowboys riding their rawhides (so to speak) without any negative consequences. However, do you really think they would tell you (or anyone) if their viral load shot up and suddenly they had to switch regimens? Probably not, or at least they'd be much less likely to broadcast such news. Perhaps that's why you haven't heard about it but HIV specialists have.
The possibility of contracting a different and perhaps more virulent strain of HIV is true. Exactly how often this occurs is difficult to tell. (See below.) As for positive couples with undetectable viral loads barebacking and not acquiring a superinfection, see the article below that suggests HIV transmission can occur despite having an undetectable HIV plasma viral load.
The level of risk you want to take is always up to you; however, I can advise you the risk of superinfection is a risk I certainly would not advise or be willing to take. Even though you are a relative newbie to the virally enhanced world, perhaps you could do your friends a favor by passing this information on to them.
arv and contagion(FINDINGS SUGGEST HIV CAN BE TRANSMITTED FROM MSM WITH UNDETECTABLE VIRAL LOAD 2008) Jan 1, 2009
friend on arv for 2 years says he is no longer contagious is this possible
Response from Dr. Frascino
No. If he's HIV positive, he's capable of transmitting the virus. He may be confused about the terminology of his laboratory tests. On antiretroviral drugs, it is possible (and desirable) to drive his HIV plasma viral load to "undetectable" levels. However, this does not mean he is noninfectious or unable to transmit the virus to others. See below.
Unprotected Sex (FINDINGS SUGGEST HIV CAN BE TRANSMITTED FROM MSM WITH UNDETECTABLE VIRAL LOAD 2008) (SUPERINFECTION) Dec 17, 2008
I am an HIV+ man who seroconverted within the last year. I recently started dating another HIV+ man who has been positive for 22 years. I'm currently not on meds with a viral load under 400 and CD4 over 600. His viral load is undetectable and CD4 is 400+. At this point we are having unprotected oral sex and protected anal sex. In the future, we have discussed having unprotected anal sex when we both feel comfortable with our monogamous status. I know there is a risk of other STDs. However, if we've been monogamous and clear of STDs and decide to have unprotected anal sex, am I at any risk of acquiring a resistant strain of the virus if he is on meds and undetectable and I am not on meds? What about if I am on meds? Resistance tests reveal that I have no resistances to treatment.
Thanks so much for your time. This forum is a wonderful resource for the community.
Response from Dr. Frascino
This issue comes up frequently. (See below.) I have no new information to report. I would still advise against Brokeback Mountain barebacking no matter how hot your cowboy may be in the saddle.
??? (Findings Suggest HIV Can Be Transmitted From MSM With Undetectable Viral Load, 2008) Oct 23, 2008
Hi I'm 25 and HIV positive Ive been doing fine on atripla once a day and vitamins Ive been poz for 4 years now.The question that i have is that Ive been dating someone that is also positive But only dated since 07 my levels are undetectable i go to the doctor's every 3 months or as needed ,but I'm not sure what my partners levels are and we have been having unprotected sex together hes not on meds, but is always getting colds and just recently told me that he had a UTI hes had other partners but thinks its me because i take meds ,i haven't had any problems so far and i wanted to know if its anyway that I'm making him sick because I'm taking atripla ? .thank u
Response from Dr. Frascino
You are wondering if you are making your bareback-Brokeback-Mountain sex buddy sick, because you are taking Atripla??? WHAT???? No, of course not. However, you are both taking considerable risk by deciding to go commando-Rambo between the sheets. Not only are you both at risk for a wide variety of STDs, but you could also acquire each other's strain of HIV, which could have a very deleterious effect on your health. It is true that driving your HIV plasma viral load to undetectable levels with antiretroviral drugs decreases the risk you would transmit HIV to your partners, but it does not completely eliminate the risk. (See below) I urge you both to reconsider your decision to have unsafe sex, even if you are "serosorting." (See below.)
Findings Suggest HIV Can Be Transmitted From MSM With Undetectable Viral Load
Infectiousness and antiretroviral therapy: reports look set to further fuel the debate
Michael Carter, Wednesday, August 27, 2008
A man transmitted HIV to his regular male partner despite taking antiretroviral treatment and having an undetectable viral load in his blood, German doctors report in the journal Antiviral Therapy. The authors believe that this is the first recorded instance of an individual with an undetectable viral load infecting a sexual partner with HIV.
In an editorial accompanying the case report, two of the authors of what has come to be known as the "Swiss Statement", whilst acknowledging a "very low" risk of transmission from individuals taking antiretroviral therapy with an undetectable viral load, highlight what they believe to be some weaknesses in the documentation of this case. Furthermore, they point out that in their own experience "all suspected cases of transmission during antiretroviral therapy turned out to have another source."
And a separately published study looks likely to further fuel the already fierce debate about the infectiousness (or otherwise) of patients being treated with antiretroviral drugs. French investigators report in the August 20th edition of AIDS that 5% of antiretroviral-treated men with an undetectable viral load in their blood had detectable HIV in their semen. None of these men had a sexually transmitted infection.
In January this year, senior HIV doctors in Switzerland issued a statement saying that HIV-positive patients treated with antiretroviral drugs with good adherence to their treatment, a viral load below 40 copies/ml for at least six months, and no sexually transmitted infections should not be considered capable of transmitting HIV sexually. The statement has proved controversial and there was a lively debate about the infectiousness of patients taking successful antiretroviral therapy at the recent International AIDS Conference in Mexico City.
The conference was also told that the lowest blood viral load in a documented case of HIV transmission was approximately 300 copies/ml. But now doctors in Germany have reported a case of transmission when a patient taking antiretroviral therapy had a sustained undetectable viral load in his blood.
The case involved a 39 year-old gay man who first started HIV treatment in 1999. Since 2000 he had been taking a combination of anti-HIV drugs including AZT, 3TC and nevirapine and had maintained an undetectable viral load. Since 2000 this patient had been in a reportedly monogamous relationship with a man of the same age.
The patient's partner reported having had had an anonymous HIV test in 2002, and a search of the records of anonymous tests conducted at the facility the patient attended showed that only one anonymous test was performed on a man at this time, the result being negative . The couple reported unprotected anal intercourse on a number of occasions since May 2003. There is no information in the case report about whether the patient and his partner were insertive, receptive, or both, and the authors failed to clarify this issue when contacted by aidsmap.com e-mail.
In July 2004, the patient's partner was diagnosed with HIV, and tests conducted shortly after showed that his CD4 cell count was 338 cells/mm3 and his viral load 21,800 copies/ml. Such a viral load would have been modest for an individual experiencing HIV seroconversion.
The investigators performed phylogenetic analysis which suggested a close relationship between the virus in the patient and his partner. Neither partner reported a sexually transmitted infection.
"We feel confident", write the report's authors, "that the present case report suggests that transmission can occur despite undetectable plasma viral load. Therefore, we cannot support any recommendations that abandon the use of safer-sex practices in this context without mentioning the possibility of HIV transmission."
But the authors of the editorial accompanying the case report highlight what they believe are some weaknesses with the reporting of the case. Although they acknowledge that the phylogenetic analysis indicated a linkage between the virus in the two individuals, they write "an infection by an epidemiologically linked third individual is only ruled out by sexual history, which is notoriously unreliable". They also suggest that "the recollection of a non-documented HIV antibody test more than 5 years earlier is a considerable weakness of this report."
However, the editorial's authors also believe that even a well-documented case report of sexual transmission of HIV involving a patient taking anti-HIV drugs with an undetectable viral load would "not indicate that this practice is associated with a risk of sufficient magnitude to have public health implications." They draw an analogy with oral sex, where individual cases of HIV transmission have been reported.
Detectable viral load in semen when viral load is undetectable in blood
A separate French study has found that 5% of 145 HIV-positive men enrolled in an assisted conception study had detectable viral load in their semen, despite having an undetectable viral load in their blood.
The men provided paired blood and semen samples between 2002 and January 2008. The lower limit of detection for HIV in blood was 40 copies/ml and 200 copies/ml for semen. In the vast majority of samples (85%), HIV was undetectable in both blood and semen.
But in 3% of samples HIV was detectable in both body fluids, and in 6% viral load was undetectable in semen, but detectable in blood. The remaining 5% of paired samples showed that HIV was undetectable in blood, but detectable in semen.
The investigators note that the patients in this 5% had all been taking antiretroviral therapy for at least six months and had maintained a blood viral load below 40 copies/ml. Furthermore none of these patients had a documented sexually transmitted infection.
On the basis of these findings the investigators conclude, "for serodiscordant couples with a desire to have a child, assisted reproduction technology remains a preferred method, when accessible to avoid HIV transmission".
Sturmer M et al. Is transmission of HIV-1 in non-viraemic serodiscordant couples possible? Antiviral Therapy 13: 729 732, 2008.
Vernazza P et al. HIV transmission hunting the chase for low risk events. Antiviral Therapy 13: 641 - 642, 2008.
Marcelin A-G et al. Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma. AIDS 22: 1677 79, 2008.
Really concerned about reinfection (SUPERINFECTION, DUAL INFECTION, 2008) Aug 16, 2008
I have been HIV poz for a year now. My concern is for the last 2 months I have have unprotected sex with 2 people 1 twice and the other 2 times. They were both HIV poz my worry is we didn't use condoms and they caused me to bleed. One is taking Atripla the same meds I am taking and is un detectable and the is very healthy and undetetable too. What are the odds that I got reinfected. I don't drink or do drugs. I have been stupid. Should I be freaking out right now. I haven't told my doctor as I am ashamed and embarrassed because I am usually extremly safe and cautious I even read about the reinfection. Please help.
Thanks a very worried person
Response from Dr. Frascino
You had unprotected sex with "2 people 1 twice and the other 2 times"???? Wouldn't that be having sex with 2 people both twice??? No matter, on with your question!
HIV reinfection (dual infection) can occur. However, exactly how often this actually happens is difficult to assess. It appears to happen more frequently in early-stage infection. That your 2x2 guys both have undetectable plasma HIV viral loads decreases the risk of viral transmission significantly. I'll reprint some information below about this topic from the archives. You can read much more if you search the archives and related links.
Finally, you should never be concerned about leveling with your doctor. He's on your side. He's there to help you, not pass judgment on indiscretions!
poz to poz sex,guy prefers no condoms (POZ ON POZ BAREBACK) Jun 11, 2008
I recently had sex w/a person and when we started,I exposed my status.I was surprised when he also is Poz and he enjoys the sensation of me depositing my load in him.Sounds great to me-I like to implant my seed,so is there really a problem w/this.I searched for an answer,yet didn't see anything + or - about this.
Response from Dr. Frascino
You searched for an answer and didn't find anything about this topic? Hmm . . . I don't think you searched all that hard! See below.
Positives with Positives- their risk of going bare- any studies? Apr 11, 2008
Hawaii says aloha from someone who knew you down in the South Bay years back.
I don't know how prevalent this notion is nationwide, but on this island it seems the prevailing attitude is (with a huge dose of wishfull thinking and condom fatigue)that positives having sex with each other can now fuck without comdoms, that the HIV risk is low. It is the prevailing behavior I fear and I am not sure how to defend against it. I'm wondering if there are any definative studies or even if such a study is possbile. I'm hearing answers all over the map- that one can't catch someone elses virus, that undectables can't be reinfected, to- one can catch a multi drug resistant strain even if undectable. The positive community seems distrustful of the prevention community because they will "tow the line" and say what they are told to say. Is there solid eveidence to base these crucial desisions on. This is from one who went through hell and came back to life and is 12 years out undectable. I am becoming sexually active after a long absense and feel a bit like I did back in the 80's, dazed and confused. What can I know for sure with so many variables,let alone alllll the other STD's from which I was spared?
Response from Dr. Frascino
From the South San Francisco Bay Area to Hawaii??? Nice! Certainly beats moving to Fargo or Crawford! If you continue on your current trajectory you should next wind up in Fiji or perhaps Sydney, both of which are also excellent habitations!!
The poz-on-poz story is indeed somewhat confusing and complicated, as you stated, by everything from condom fatigue to wishful thinking to anecdotal stories. So here are a few realities that might help:
For poz-on-poz, neg-on-neg or any combination in between, unsafe sex places both individuals at risk for a wide array of STDs. STDs can behave differently in folks with HIV (or compromised immune systems from any other cause as well). Hepatitis, syphilis, HPV and many others can have far more serious consequences for HIVers than for those with intact immune systems. This fact alone should be enough to convince HIVers that unsafe sex isn't worth the risk.
Dual infection (superinfection, reinfection) is indeed possible and has been well documented scientifically. What we don't know is exactly how frequently this actually occurs. It appears to happen more frequently in early infection. I'll report below some information about dual infections.
Hope that helps! Enjoy I have already responded to one of those fancy cocktails served in a pineapple with the little umbrella sticking for me, OK?
poz to poz barebacking risky? Feb 4, 2008
Hi Dr. Bob, I became virally enhanced in 2007 and I'm still trying to adjust to the reality of it. My questions relate to barebacking between 2 poz guys. My doctor has warned me to always always use condoms now to prevent superinfection with a different strain and to prevent transmission of resistance. But when I chat with other poz men or read their online profiles I can't find any poz men who use condoms with other poz men. Is the risk of superinfection and resistance real? If my partner and I bareback(we both show no resistance on tests)are we still risking our health? Is a top less likely to obtain resistance or superinfection from a bottom? I'm just confused by this because I want to do the right thing and follow my doctor's advice but I'm beginning to think that very few poz men use condoms if their partner is also poz. I would appreciate your insight. Thank you.
Response from Dr. Frascino
Hi Poz Newbie,
You can't find any poz men who use condoms with other poz men online? Hmm . . . dude, you need to change chat rooms.
"Is the risk of superinfection and resistance real?" Yes, it is. (See below.) What we don't know is exactly how often it actually occurs. It seems to happen more during early infection. This may correlate well with the evolving data on decreased infectivity seen in the face of an effective antiretroviral regimen and fully suppressed (undetectable) HIV plasma viral load. (See below.)
If you and your partner decide to go commando Rambo on each other's backside, are you risking your health? Yes, all unprotected penetrative sex presents some degree of risk for not only HIV dual infection, but also for other STDs.
As for top versus bottom, the receptive (bottom) partner is always at greater risk for acquiring an infection.
Superinfection (SUPERINFECTION) (DUAL INFECTION) (REINFECTION) Nov 23, 2007
I was recently diagnosed with HIV last week so I am still learning more and more every day. I know that it is early but I would like to get a head start to prolong my life. I have been with my boyfriend for two years; he was the one that infected me. I still plan on being with him since he did not give HIV to me on purpose. We currently do not use condoms since we are in a monogamous relationship. Since we are both HIV+ we figure that we can still go "bareback." I have been reading material on this thing called a superinfection when you can get infected with another strain of HIV.
My question is: Since he gave me HIV, we both have the same strain, can we continue to go "bareback?" Will this change once we start on different med regimens? PLEASE HELP.
Response from Dr. Frascino
This question comes up frequently. (See below.) At this point, what we know is that superinfection can and does occur, but we do not know how frequently it actually happens. It appears to be more common early in the course of infection. Our advice at this point is to use condoms even in poz-poz relationship. The information below explains the rationale for our recommendation.
Good luck. Stay well.
superinfection (SUPERINFECTION) (DUAL INFECTION) (CO_INFECTION) (REINFECTION) Nov 19, 2007
I was infected in June07, having been a public dump at a $4 theater already for months. The same 5-10 men are using me weekly, another 10 a month are new, & another 3-4 a month are negative people wanting to have sex with me, which I have took advantage of. My CD4 was849 in july now 526(26%) , viral load was 152,000 now 80,030.I am not scheduled for labs till end of Jan. At the present rate I will have aids by then. I'm new at this. Am I superinfected?
Response from Dr. Frascino
Sorry to hear about your recent diagnosis. I would suggest, because this is indeed "new" for you, that you get informed about HIV, HIV-monitoring tests, HIV treatments and HIV transmission. A good place to start is to read through the information under the "Quick Links" heading on The Body's homepage. There you will find chapters on "Just Diagnosed," "HIV Monitoring Tests," "HIV Medications," etc.
Regarding superinfections, I'll repost some information about this from the archives. The way to prevent superinfection (and a variety of STDs) is to properly use latex condoms for penetrative sex.
As for your fear that you'll have AIDS by the end of January, I would seriously tend to doubt this. However, you do need to begin protecting yourself and your partners. Please note you are legally required in most states to disclose your HIV status before having sex with them.
Also it might be helpful for you to know I've been HIV infected since January 1991 and I'm still here. A long and satisfying life with HIV is indeed possible, but you'll need to get informed and begin taking responsibility for your health.
couple with AIDS Nov 4, 2007
Thank you Dr. Bob for your reply. Yes, we are seeing a very good doctor. But we had to go through a lot of doctors and tests to find out what was wrong with us. My boyfriend and I do plan on using condoms from now on. But I guess I was just wondering how it already affected us up till now. We were probably still both just HIV status before we met, but we are in our 40s and did not use protection. We both started getting sick fast about a year ago. Do you think that we caused each other to drop faster?
Response from Dr. Frascino
I have no way of knowing, in fact, over the Internet whether you and your partner actually did acquire each other's viral strain and if so whether that dual infection resulted in further more rapid progression of your illnesses. In any case, life only moves in one direction forward. Stop worrying about the past and focus on the realities of today and the promise of tomorrow, OK? I'm glad you are both now under the care of a competent HIV specialist.
Good luck to you both!
couple has AIDS Nov 2, 2007
Dr. Bob, My boyfriend and I both were diagnosed with AIDS this past August. His t-cell count was 89 and mine was 6. We have only been together for 2 years. I just moved back to this state 3 years ago. Before we met, we were both married. It seems unreal that we both had HIV before meeting each other, and that we had it for probably the same length of time. What will it do if we have unprotected sex now?
Response from Dr. Frascino
Another two married dudes (who certainly never should have been married in the first place) who had longstanding HIV/AIDS infections and you didn't know it until this past August???? Hmmm . . . here we have additional evidence once again that our HIV/AIDS awareness and prevention programs in the U.S. are an abysmal failure!!! It's frustrating, disconcerting and sad that over 25 years into the pandemic with over 25 million lives snuffed out by the virus, stories like yours are still so prevalent.
Now getting off my soapbox, I'll move on to your question. You both have advanced-stage AIDS. If you decide to have unprotected sex, you run the risk of contracting a superinfection. In other words, you could each contract the other's strain of virus. This theoretically could make your HIV disease progress faster or become more difficult to treat. For instance, if you or your partner picks up a strain that is resistant to one or more of the medications in your regimen, this could have disastrous consequences. Exactly how often superinfection (dual infection) occurs, we don't know. What we do know is that it is possible. You can read about dual infection or superinfection in the archives. Personally, this is definitely not a risk I would take.
I trust you are both under the care of a competent AIDS specialist physician. If not, you should be!
Good luck to you both. I'm here if you need me, OK?
serosorting & unprotected sex between 2 hiv + men (SUPERINFECTION) (DUAL INFECTION) (CO_INFECTION) (REINFECTION) Sep 28, 2007
my boyfriend and i (we are gay males) have been dating for a while. we met after we were both diagnosed with hiv. we prefer anal sex without condoms - what is the most recent data and information on reinfection? we are on different hiv anitretroviral medication. both our viral loads are undectable and our t cell counts are 400-500 range.
Response from Dr. Frascino
No doubt almost everyone poz or neggie would "prefer" sex (anal, vaginal, oral or otherwise) without the latex packaging. The real question is whether it's worth the risk! What we know about dual infection (reinfection or superinfection) is that it can indeed occur and that it can have catastrophic consequences. What we have learned more recently is that this unfortunate and completely avoidable situation occurs less frequently than we originally feared. Recent data indicate it occurs most readily in cases of recent HIV infection. Collecting data on reinfection cases is difficult and performing controlled clinical trials would be unethical. Consequently the best we can do is collect anecdotal and epidemiological data. Only you and your partner can decide if the risk is worth the pleasure. Also "no-glove love" leaves you both open to all other STDs as well. Any STD may have the secondary effect of increasing HIV replication and plasma viral load, which, in turn, could increase your risk for developing resistance to HIV medications. I'll reprint some information about dual infection from the archives below. Based on what we now know, the recommendation for safer sex (condoms), even between two poz partners, remains unchanged. The risk you and your partner are taking is not one I would personally accept.
Good luck to you both, whatever you decide.
raw meat! (SUPERINFECTION) (COINFECTION) Mar 17, 2007
I am poz and so is my partner. He insists on barebacking me. I argue with him but I always end up taking his load. Is this going to make me die sooner? What effect will having a big load dumped in me almost every day do to my health? I am on meds am undetectable and my partner is also undetectable. does this make a difference? Also I am on a P.I. and he has never been on one. Oh yeah, he shoots an exceptionally big load...does that mean more hiv per load?
Response from Dr. Frascino
Even poz-on-poz barebacking is risky business. Will it make you die sooner or have a deleterious effect on your health? Theoretically it could, if you were to become coinfected with a more aggressive strain of HIV. That your partner has an undetectable plasma viral load (at least as of his last blood draw) would decrease, but not eliminate, the risk of HIV transmission. I'll reprint some information below from the archives that discusses coinfection/superinfection. Finally, I should point out while your partner may "insist on barebacking," it takes two to do the commando unsafe mattress mambo!
You have the power to insist "no glove, no love, no exceptions!"
hiv and sex (SUPERINFECTION) Jan 12, 2007
Both my partner and myself are hiv +. He contracted hiv from me. We have been totally monomagous in our relationship since meeting over 16 months ago, me getting hiv from another person prior to meeting him. I am on both truvada and sustiva at this time. As of last week my viral count is undetectable, and my cd4 count has now climbed back up to the 640's, was in the low 400's earlier. My partner is not on meds at this time and his viral count is still detectable and his latest cd4 count was in the 400's. I have problems maintaining an erection with condoms, which is what got me and him in this condition to begin with. Although we tried to be "safe", things failed. I love him very much as he does me. Question is, Are there risks if we were to start back with totally unprotected sex between us, with both of us now hiv + and knowing for sure that he contracted hiv from me? Are there risks of creating more problems, specially since I am on meds at this time and he is not.
Response from Dr. Frascino
Yes, the risk of superinfection is indeed real, even though we do not know now often it occurs. (See below.) If you are having difficulty maintaining your erections, talk to your HIV doctor. Erectile dysfunction is quite common in HIV+ men. Viagra or Cialis may be worth a try.
Serosorting vs Superinfection Jul 23, 2006
first of all i really love your way of handling questions and answering them. It brings some humour to it all, which i feel is more than necessary.
I'm HIV+ for 4 months, diagnosed right in the middle of seroconversion period, probably infected end of february. Current numbers : april: CD4:400, VL:180000, may : CD:480 - VL:1530 (will get new numbers in 14 days) I do have 2 questions :
Q1: 1 month ago, I met 2 guys in our local support center. We ended up having sex - unprotected, which of course was a foolish thing to do and it was the first time i ever did it, no excuses there besides maybe being angry with myself. Anyway: i know one is taking medication (first regime) is said to be "fast progressing", the other one is poz but undetectable - no meds. I've been reading about possible superinfections in several articles, and on the other hand reading about serosorting and the ability of poz men having sex with poz men without much risk. I'm however pretty worried about having a possible superinfection. My question is : how severe is this risk of superinfection and should i even consider serosorting ? (i know about the risk of other SOA's but the risk there is very clear).
Q2: This question is related to Q1: My meds specialist, as an introduction to ever needing meds, informed me about the risk of becoming immune due to receiving parts of the medications given by the other guy through the semen while being infected. It would be a possible i may have built up some resistance without even taking any meds. I'm afraid the same happened now with my latest endouver, knowing one of them was on a first regime meds. How real is this threat ? Should i really be worried ? Should I talk about it with my hiv specialist ?
Thx ahead, you're support is really appreciated !
Response from Dr. Frascino
Q1) Superinfection is indeed a real risk for poz-on-poz barebacking. I've addressed this topic and serosorting many times in this forum, so I'll just repost a few questions from the archives and encourage you to search the archives for additional information if you so desire.
Q2) Developing resistance to HIV drugs is not the result of "receiving parts of medications given by the other guy through the semen." Perhaps something must have gotten lost in translation as your specialist was trying to explain the phenomenon of acquired resistance to you. What really happens is that an infected person can become superinfected or dually infected with strains of HIV that have developed resistance to one or more anti-HIV medications. This, too, is discussed in the archival posts below.
My advice remains to stay safe.
POZ with POZ
Jul 18, 2006
I am a healthy POZ sexually active gay man, generally a bottom. I have always been of the opinion that condoms are a good idea, period. They reduce the chance of more than just HIV. But lately I have frequently heard POZ guys saying that they bareback with other POZ guys because everyone is getting treated and doing so well. Comment please.
Response from Dr. Frascino
Hello Poz Guy,
I agree with your rational and would extend it somewhat. Condoms protect against a host of nasty STDs, many of which are on the upswing among men having sex with men. An active STD can indirectly cause your HIV viral load to skyrocket. As viral replication goes up, so does the chance that the virus may mutate into a form that may be resistant to one or more of the medications in your current regimen.
Next, the possibility of a dual infection or superinfection is real. Although, we do not know how often this actually occurs, we do know that it can occur. Is that a risk you're willing to take? It's one I certainly would not. I'll repost a few questions from the archives that give further details on this topic.
Stay safe. Stay well. Be here for the cure.
Is safe sex necessary if both partners are + Dec 28, 2005
My husband and I are both positive and I was infected by him. Our Dr. says we must have safe sex or we can make each other sick. Is this true? It seams weird. Also I saw people were having trouble getting insurance after that were diagnosed +. I work for Anthem and they cover pre-exhisting conditions like HIV. I had no problem adding my husband to my policy, even thought he had been positive for over 6 years.
Response from Dr. Frascino:
Your doctor is cautioning you against the possibility of superinfection or reinfection. Even if you were initially infected by the same strain of HIV, the virus can evolve differently in each person. Consequently, over time your virus may be quite different from your husband's. I'll post several articles and a question from the archives that address this topic. I hope you'll consider this information carefully. Stay well.
How safe does HIV+ couple have to be? Aug 26, 2004
You inspire and console many, and are appreciated by the positives and negatives in this fight.
Ok, here is my question, I have been dating another HIV+ man for over a year and we have entered a committed relationship. We are both in our 50's and look forward to a great long life together. Both of us are on a drug regiment and have undetectable viral loads. We both have a good T-cell count and both of us are very healthy. If we live in a committed and monogamous lifestyle, how dangerous would un-protected sex be if we both have the HIV virus already, and are both compliant on our drug regiments?
We are very happy with our current safe sex practices, but are curious what you would say to this question.
P.S. Our doctors are evasive, first telling us about the risks of super infection, but then eluding to the fact that it would be unlikely.
Thanks! Curious in Boston
Response from Dr. Frascino
Hello Curious Boston Boys,
Actually your doctors are right on target. There is indeed a risk of superinfection. Cases of superinfection have now been well documented. The question of how often it occurs remains unanswered. That might explain your doctor's seemingly "evasive" comments. In reality we don't have a lot of information about the frequency of HIV super-infection because it's not all that easy to document without rather extensive and costly analysis. Certainly the major concern is the acquisition of a more virulent (aggressive) strain of HIV, or one that is resistant to some of the drugs in your current regimen.
As two consenting adults, only you and your partner can decide if you are willing to take this risk. You mention you are "very happy with your current safe sex practices." All I can do is advise you that the risk of superinfection is real, very significant, and potentially devastating. Even though the chance of HIV transmission is decreased by having undetectable viral loads, HIV superinfection is not a risk I would not be willing to take personally. Good luck, Boys. There may be some more information on this topic presented at an HIV/AIDS medical meeting in your hometown scheduled for February 2005. Stay posted to this site and I'll keep you posted as well!
Re-Infection: Is It a Concern for People Living With HIV? May 2004 Re-infection is a term used to describe a new or secondary infection by a virus that has already infected a person. In most viral diseases, re-infection with the same virus doesn't occur because once the immune system conquers the original viral infection, it creates immunity against that virus. Re-infection occurs almost constantly, however, in some types of infection, such as the cold or flu viruses, because each new version of those new viruses is substantially different from the last. This is why a person may develop immunity to the flu strain that is common in one year, but still be at risk from the strain that becomes dominant the next year.
The question of re-infection with HIV has long been debated. There is no theoretical reason to think re-infection isn't possible, since the immune system never fully conquers the initial HIV infection. Still, many people, including many physicians, clung to the hope that re-infection with HIV either does not happen or that it only happens rarely. This view is the basis of the belief held by some HIV-positive people that having sex or sharing needles with another HIV-infected person poses little or no risks. Many if not most virologists, however, have long believed that re-infection is both possible and perhaps even likely. What is not known are the individual short- and long-term clinical consequences (which may vary from person to person for wholly unknown reasons). For many years, there were no clear cases of re-infection presented at scientific conferences, but this did not mean such re-infection wasn't occurring. Instead, we know that finding and documenting cases of re-infection is extraordinarily difficult, if for no other reason than that no structured program has looked for them. Finding a case of re-infection has largely been a matter of chance. Yet, several observations over the years support the notion that re-infection is possible, including observations of sex workers in Africa infected with several different recombined "clades" of HIV as well as detailed genetic analysis of a few people's virus suggesting that re-infection was possible. This research is very difficult to conduct. Perhaps the only simple example of re-infection is in western Africa, where people are routinely found who carry both HIV-1 and HIV-2. At the very least, this proves that having HIV-1 does not protect a person from infection with HIV-2. Recently, there has been considerable media attention about a few well documented cases of suspected re-infection with two versions of HIV-1. The most interesting case, presented by Dr. Bruce Walker, was the result of an almost accidental observation. While researching the effects of Structured Treatment Interruption (STI) in some newly infected volunteers, Walker's team was intrigued by one particular case in which the volunteer responded well to two initial cycles of STI. After each, the person's viral load remained undetectable for several months without treatment. Shortly after a third STI, however, the viral load remained low for only a brief period and then suddenly soared upward. The team wondered what made things different this time? After conducting extensive genetic analysis, they found their answer: the volunteer had become infected with a second, slightly different strain of HIV. Most striking, and discouraging, was that the genetic makeup of the new infection differed by only 12% compared to the original infection. Despite this small difference, the second infection had completely escaped control by the immune system, breaking through the suppression achieved against the original virus. This discovery, while important enough in regards to re-infection, also had discouraging implications for vaccine development, suggesting that as little as 12% variation between viruses might be enough to make a vaccine fail.
Several questions remain in regards to re-infection. Will re-infection lead to more rapid disease progression? Will re-infection with HIV result in transmission/acquisition of drug-resistant HIV that will limit a persons' anti-HIV treatment options? Both of these concerns are theoretically possible, and both have now been demonstrated in case studies. Currently there is not a large amount of data to assess the actual risk to the individual. Although only a little data currently exists and it is extremely difficult to gather more, it does not lessen the real potential for re-infection or its consequences.
There are several reasons why people living with HIV would want to maintain safer sex activities. While the clinical implications of re-infection remain unknown (and will likely be unknown for many years to come), there is some evidence of harm and no evidence of harmlessness. We also know for certain that safer sex does protect against many blood-borne infections that are major causes of life-threatening diseases and death in people with HIV. These likely include CMV, some forms of hepatitis virus, genital herpes, possibly the JC virus (cause of a particularly destructive condition known as Pml), to name a few.
Ultimately people living with HIV need to consider this information and make informed decisions about safer sex for themselves. In the early 1980s many did not want to believe that HIV was caused by unsafe sex. Many people have dearly paid the price for that belief. The optimal outcome here is for people not to fight against data and shy away from acknowledging the potential consequences of re-infection. Some people will come to a conclusion that it's better to be safe than sorry. Others will choose the risk of being sorry rather than safe and will continue to participate in unsafe sex with positive partners. What matters most is that people make a conscious decision based on the available information.
HIV Superinfection 5% in Newly Infected Gay Men
Coverage provided by Keith Henry, M.D. February 9, 2004
Dr. Smith and colleagues presented their experience looking for cases of HIV superinfection in the cohort of HIV-positive patients that they followed after identification of primary infection. The topic of superinfection is important for several reasons. First, it provides important insight into protective anti-HIV immunity. The issue is whether the innate anti-HIV immunity that evolves in an infected person can prevent infection with a second strain of HIV. That is important clinically since a few anecdotal reports have suggested that superinfection can lead to more rapid deterioration of a patient's immune status. It is also important from the public health perspective with implications for the potential efficacy of a vaccine to prevent infection.
Several definitions need to be clarified. Co-infection describes when someone is initially infected with two strains, while with superinfection a patient is infected with one strain and then with another strain. Superinfection has been observed in some chimpanzee models and has been inferred from recombination analysis but is still a rarely documented clinical event.
Smith reported the results of a retrospective analysis of trials of primary infection in a cohort of 78 men who have sex with men (MSM) during their first six months living with HIV infection. These men were not yet on antiretroviral therapy. Samples of virus underwent pol gene sequencing and if isolates didn't cluster then env sequencing was done.
Three cases of possible superinfection with another type B virus were identified and then confirmed by clonal sequencing of env and pol sequences. All three men had a change in the reverse transcriptase sequence that could impact drug sensitivity. When those three patients were evaluated six months after acquiring the second strain, a negative impact on the CD4 count and RNA level was seen.
The 5% rate of superinfection is about the same rate as at risk infection initial infection in high-risk populations in the U.S. The interpretation was that there was no protection afforded by the initial HIV infection against superinfection. Dr. Smith said that the lab approach may underestimate the true rate of superinfection due to sensitivity issues with the assays used. It seems to me that a group of MSM with fairly recent HIV infection may represent a group with a higher than average risk for acquiring additional HIV so that extrapolation to the general MSM population may overestimate the overall risk. Whatever the actual rate is, these data add to the literature about superinfection and support enhanced emphasis on harm reduction counseling. A question from the audience highlighted that of the three cases reported, two had been previously reported in other reports. Clearly the topic is of interest and more studies looking at the rate and impact of superinfection are needed.
barebacking risks Mar 19, 2006
Thanks for your response to my questions regarding barebacking. I looked up the BETA articles you suggested and I want to tell you, even though I know a lot about HIV and HIV transmission, I certainly learned a mountain of new information in these articles. I was, impressed with the details on safer sex as it relates to the various forms of sexual activities. But, I was most surprised to learn that there have been virtually no known cases of HIV dual infection in any HIV+ individual who has been positive for more than three years. That would explain why barebacking has not truned out to be the horror clinicians initially thought it would be. In my experience, the overwhelming number of barebackers out there seem to be long-term positives and probably positive for three or more years. Yes, STDs are still a risk. And, certainly, any responsible barebacker (if that is not an oxymoron) should stay away from partners who are newly infected. I also understand that this phenomenom of no coinfections after three years) is a source of great interest to scientists in finding a vaccine for HIV. I hope you will print this and suggest that everyone out there do their own research, as well. Keep up the good work.
Response from Dr. Frascino:
Yes, I agree BETA did a fine job with their article, which is why I gave you the whole reference rather than just trying to summarize the key points. I'll reprint it below for those readers who may have had difficulty downloading the reference.
Stay well. Stay informed.
Dual HIV Infection
A number of individuals infected with more than one strain of HIV have been identified over the past few years. Should people already diagnosed with HIV be concerned? Given the limited number of cases seen so far, the risk of multiple infections (also called dual infection) appears to be quite low. And there are many more pressing health concerns facing people living with HIV/AIDS. Nevertheless, two trends are worth noting: dual infection seems more likely to happen under certain conditions, and it is associated with faster progression to AIDS-related events. This article describes current evidence and theories behind this emerging phenomenon. Coinfection, or infection with more than one viral strain at or near the same time, is believed to occur around the time of initial infection. (Initial infection is also known as acute or primary infectionthe period before seroconversion that usually lasts from a few weeks to a few months.) Reinfection with a different strain, also known as superinfection or serial infection, presumably takes place later on during early infection (the first few years of HIV disease, after seroconversion) or chronic (long-term) infection. Researchers make a distinction between two types of dual, or multiple, HIV infection: Gathering Evidence Experts once hoped that a single HIV infection would prevent further infections, much like a vaccination. In the mid-1990s, however, studies using analogous viruses in primates showed that sequential infections were possible. Some people believed it was only a matter of time before something similar would be seen in humans. Compelling evidence of dual HIV infection in humans appeared in 2002. A report in the Journal of Virology in August of that year strongly suggested reinfection in two injection drug users (IDUs) from Thailand (one female, one male). The woman was initially diagnosed with HIV subtype AE only, followed by detection of subtype B approximately two months later. The man was apparently reinfected with subtype AE virus approximately six to ten months after his primary diagnosis with subtype B virus. Neither individual was being treated for HIV during the study period. In the September 5, 2002 issue of the New England Journal of Medicine, researchers from the University of Geneva reported on a man initially diagnosed with subtype AE virus in November 1998 whose viral load became undetectable (below 50 copies/mL) with antiretroviral therapy. He stopped treatment in January 2001 and shortly thereafter traveled to In theory, any apparent case of reinfection could be a case of coinfection in which one of the coinfecting strains remains undetectable until it emerges sometime after seroconversion (the point at which HIV antibodies can be detected and a person can be diagnosed as being HIV positive). This is sometimes called sequentially expressed coinfection. Testing limitations that prevent detection of very small viral populations in the body make it difficult to distinguish between coinfection and reinfection. Researchers believe that until a source partner for dual infection is found and the timing of exposure confirmed, it is not possible to determine that the second virus was acquired after seroconversion. While finding source partners is a continual problem, determining the timing of exposure is aided in some cases by the emergence of acute retroviral syndrome (often flu-like symptoms, including fever and fatigue) in the person presumed to be reinfected. It is not known whether overgrowth of a previously dormant coinfecting strain might also trigger acute retroviral syndrome. COINFECTION AND REINFECTION WINTER 2006 BETA 37 Brazil, where he had multiple unprotected sexual contacts. In April 2001, three weeks after his return from South America, his viral load spiked to 400,000 copies/mL and he reported symptoms of acute retroviral syndrome, which can signal a new HIV infection. Lab tests subsequently detected a second strain of HIV subtype B, which is common in Brazil. The researchers concluded that reinfection had occurred. More recently, Davey Smith, MD, of the University of California at San Diego and colleagues reported in the August 12, 2005 issue of AIDS that a man with wild-type (drug-sensitive) subtype B virus was apparently reinfected about a year after his first infection with a different subtype B virus resistant to protease inhibitors, which he had never taken, and 3TC (lamivudine, Epivir), which he started only after the second infection. Another case of dual infection with two subtype B viruses with discordant drug sensitivity was reported by the same research group in 2003. In that case, however, the subject was first diagnosed with drug-resistant subtype B virus and then found to have wildtype HIV of the same subtype four months later. Like the man in the 2005 report, this individual had not taken antiretroviral therapy before the apparent reinfection event. Other cases of multiple HIV infection have been identified in the past four years, although the total number remains smallonly 16 apparent reinfections by one measure (a 2005 Medscape survey of the scientific literature done by a group from the Gladstone Institute of Virology and Immunology in San Francisco). The Gladstone researchers, however, did not consider cases of coinfection. In addition, dual infection rates may be higher than reported, since few people with HIV have been tested for multiple strains. Only larger future studies using more sophisticated technologies and better tracking of source partners can provide a clearer picture of the incidence (rate of new cases) and prevalence (total number of existing cases) of coinfection and reinfection in a given population. Impact on Disease Progression Dual infection in humans has been linked to disturbances in immune control and poorer prognosis. In the case of the man who traveled to Brazil, the emergence of his subtype B virus while off therapy coincided with a loss of 300 CD4 cells/mm3 and a dramatic rebound in viral load before he resumed highly active antiretroviral therapy (HAART) four months later. HIV Recombination Different varieties, or strains, of HIV are grouped in a hierarchy. At the broadest level are the two types of HIV: HIV-1 (most prevalent worldwide) and HIV-2 (rare except in West Africa). HIV-1 is divided into three groups:M (major), N (new), and O (outlier). Group M is by far the most common of the three, and is itself subdivided into different clades or subtypes: AD, F, G, H, J, and K. Different subtypes can infect a cell and create hybrid or recombinant forms, such as AC (or A/C). Circulating recombinant forms, or CRFs, are genetically mixed subtypes (such as CRF02_AG) that are found in more than one person. Types HIV-1 HIV-2 | Groups M N O | Subtypes A B C D [E]* F G H J K (Clades) | recombinant forms and CRFs * E does not exist on its own, although it appears in certain CRFs Most recombination events seen thus far are between different subtypes. But infection with two genetically distinct viruses of the same subtypefor example, two subtype B virusesis also possible. The potential for recombination among these is unknown. At the same time, science has yet to reveal what might result from viral mixing among different HIV groups or types. But research opportunities might come soon. At the 2005 Retrovirus conference, a French team claimed to have detected the first reinfection of a group O-infected woman with a virus from group M. Almost more remarkably, the research group located the source of her second infection, the gold standard for confirming secondary infection that has eluded other investigators. While it is generally believed that dual infection must occur for a recombinant virus to be formed, an unusual case of viral recombination in a singly infected woman was reported at the 3rd IAS conference this past July. B. Weiser of the New York State Department of Health and colleagues found that this individual's drug-sensitive HIV evolved differently in her plasma and genital tract after starting HAART and recombined into a multidrug-resistant strain within six months. Viral recombination might play a significant role in accelerating HIV disease (see sidebar on page 37). Recombination increases viral diversity more rapidly than mutations that evolve slowly through replication errors. Recombinant viruses may be less sensitive to anti-HIV drugs and are potentially more virulent than nonrecombinant viruses. This might result from altered tropismspecifically, the virus' ability to use the CXCR4 coreceptor to enter cells, as was the case in the New York man; CXCR4-using viruses are associated with worse disease outcomes than viruses that use the CCR5 coreceptor. Genetically mixed viruses might also be more adept at evading immune responses in a type of evolutionary strategy. At the 3rd International AIDS Society (IAS) conference this past July, Carolyn Williamson, PhD, from the University of Cape Town and colleagues reported finding recombinant virus in six of six dually infected subjects, along with evidence of viral evasion of cellular immune defenses and neutralizing antibodies. The South African team proposed that dual infection "enables recombination to contribute significantly to viral adaptation to immune responses...and may help explain rapid disease progression." Alternatively, the link between dual infection and disease progression might be a product of individual characteristics. Gottlieb has speculated about whether certain people who are inherently predisposed to faster disease progression may also be more susceptible to reinfection. His team noted in their 2004 report, for example, that the one subject believed to be reinfected "had rapid CD4 decline immediately after initial infection, suggesting a host susceptibility to infection with a second virus." Susceptibility and Protection As to when reinfection might occur, data collected so far show an interesting trend. Researchers at the Gladstone Institute pointed out in In a report from 2004, Smith and colleagues analyzed the two dual infection cases mentioned above plus a third man with apparent secondary infection (wild-type followed by drugresistant virus). Among the three men, CD4 cell counts dropped an average of 132 cells/mm3 within six months of acquiring the second strain, while viral load levels increased an average of 1.6 logsa 40-fold increase. Geoffrey Gottlieb, MD, of the University of Washington in Seattle and