Turmeric and Atripa

Question

Is it ok to take Turmeric supplements with Atripla? I've heard that turmeric boosts the Cytochrome P450 system. Could this reduce the half-life of the components in Atripla?

Answer

Good question. The components of tumeric can vary from product to product. Data is limited. If any reader is aware of a published reference looking at tumeric and efavirenz or Atripla please post. I would generally not expect a clinically significant interatction but would inform your HIV provider so he/she can monitor. See below from Wikipedia entry on tumeric:

Turmeric is currently being investigated for possible benefits in Alzheimer's disease,[6] cancer, arthritis, and other clinical disorders.[7]

In the latter half of the 20th century, curcumin was identified as responsible for most of the biological effects of turmeric. According to a 2005 article in the Wall Street Journal, research activity into curcumin and turmeric is increasing, with supplement sales increased 35% from 2004. The U.S. National Institutes of Health currently has registered 19 clinical trials underway to study use of dietary turmeric and curcumin for a variety of clinical disorders (dated February 2010).[8]

KH