PEPFAR -- the U.S. President's Emergency Plan for AIDS Relief -- was launched under President George W. Bush in 2003. At the time, global investment in HIV programs in developing countries was practically non-existent. The Global Fund to Fight AIDS, Tuberculosis and Malaria was launched in 2002 with funding levels wholly inadequate to address the crisis. Public sector treatment programs had not even begun in most African countries as the medications necessary were too expensive and unavailable and there was limited evidence that the infrastructure or human resource capacity necessary to deliver treatment programs was adequate. PEPFAR -- by making billions of dollars available for HIV programs in developing countries -- unlocked the ability to deliver programs and fundamentally changed the course of the HIV/AIDS epidemic and the world more broadly.
Absent this enormously successful program, the world would be a remarkably different place. Download the PDF here.