Pneumocystis carinii pneumonia

Question

What are some of the latest developments in preventing and treating this infection?

Answer

THe best prevention is for people who have T cells below 200 cells to take trimethprim-sulfamethoxazole (bactrim) either daily or 3 times per week. For those allergic to sulfa, either dapsone, aerosolozed pentamidine or atovaquone(mepron) can be substituted. If the sulfa allergy was not anaphylaxis, desensitization can allow the drug to be used for some people. None of this is terribly new, but it remains very important. For treatment the drug of choice remains trimethoprim-sulfa, with other options for sulfa allergic patients that include trimethoprim-dapsone, clindamycin+primaquine, atovaquone or pentamidine , the choice of agent depends to some degree on the severity of the case. Hope this helps.

-JC