i have taken pep fouth time in one year
first time she was postiive and it worked ,second time i took for three days and i discovered she is negative so i stopped ,third time , i took for a week and i discovered she is negative and i stopped , now the fourth time i she is postive and i have just started , am worried that i may have developed resistence already please advise
all the three times i had effavirenz as part of the regimen
Hello and thanks for posting about HIV prevention.
First off, if you don't have HIV, taking PEP or PrEP can't cause viral drug resistance, since you don't have any HIV in your body. PEP and PrEP are both very highly effective for preventing HIV infection if taken appropriately (you can search our Forum pages for much more information).
Next, if you've taken post-exposure prophylaxis 4 times in 12 months, it begs the question if daily pre-exposure prophylaxis (PrEP) might be an appropriate prevention intervention for you. Since November 2015, the
World Health Organization has recommended PrEP for individuals at substantial risk of HIV infection. And before that, in 2014 the US Centers for Disease Control issued national
PrEP guidelines. The CDC guidance is notable in that the recommendations break out specific circumstances where PrEP is recommended- including men who have sex with men; heterosexuals and people who inject drugs.
Though you've not specifically stated this, I'll assume that you're a heterosexual man. The CDC recommends PrEP for heterosexuals who:
is an adult person; without acute or established HIV infection; having any sex with opposite sex partners in past 6 months; not in a monogamous partnership with a recently tested HIV-negative partner AND at least one of the following:(1) Is a man who has sex with both women and men (behaviorally bisexual), (2) infrequently uses condoms during sex with 1 or more partners of unknown HIV status who are known to be at substantial risk of HIV infection (IDU or bisexual male partner) or (3) is in an ongoing sexual relationship with an HIV-positive partner.
A key issue is that despite the 13 month-old World Health Organization recommendations, PrEP is only currently available in a handful of countries- leaving many people who could potentially benefit from this important prevention tool.
PrEPWatch.org has a nice set of resources that outline where PrEP is available (or in demonstration clinical trials) and ways to advocate for access.
It's possible to make new HIV infections a rare medical event- doing so will require that we recognize that people living with HIV who are aware of their diagnosis and have undetectable viral loads (while on treatment) don't transmit the virus; and also requires that nations fully implement and make available modern recommended tools (like condoms, PEP and PrEP) to help uninfected people (i.e., HIV negative) stay uninfected.
I hope that this is helpful.
Be well in this holiday season,