Brand Name: Lexiva
Other Names: FOS-APV, FPV, fosamprenavir calcium
Drug Class: Protease Inhibitors
Fosamprenavir can cause serious, life-threatening side effects. These include severe skin reactions or rash.
Stop taking fosamprenavir and contact your health care provider right away if you have a rash and have any of the following symptoms:
- Hives or sores in your mouth
- Skin that blisters and peels
- Trouble swallowing or breathing
- Swelling of your face, eyes, lips, tongue, or throat
Taking fosamprenavir with certain other medicines may result in serious, life-threatening side effects. Tell your health care provider about other medicines you take.
While taking fosamprenavir, it is important to keep all of your appointments with your health care provider.
What Is Fosamprenavir?
Fosamprenavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 4 weeks of age and older. Fosamprenavir is always used in combination with other HIV medicines.
Fosamprenavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
What Should I Tell My Health Care Provider Before Taking Fosamprenavir?
Before taking fosamprenavir, tell your health care provider:
- If you are allergic to fosamprenavir, amprenavir, medicines containing sulfa, or any other medicines.
- If you have liver problems, including hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV).
- If you have kidney problems.
- If you have diabetes or high blood sugar (hyperglycemia).
- If you have hemophilia.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether fosamprenavir can harm an unborn baby is unknown. Fosamprenavir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your health care provider about possible risks with taking fosamprenavir when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking fosamprenavir.
- If you are using hormone-based birth control (such as pills, implants, or vaginal rings). Fosamprenavir may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking fosamprenavir. For more information about using birth control and HIV medicines at the same time, view the AIDSinfo HIV and Birth Control infographic.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Fosamprenavir may affect the way other medicines or products work, and other medicines or products may affect how fosamprenavir works. Taking fosamprenavir together with certain medicines or products may cause serious, life-threatening side effects.
How Should I Take Fosamprenavir?
Fosamprenavir (brand name: Lexiva) comes in the following forms and strengths:
- 700-mg tablets.
- 50-mg/mL oral suspension (an oral suspension is a mixture of a medicine and a liquid that can be taken by mouth).
Take fosamprenavir according to your health care provider's instructions.
Take fosamprenavir tablets with or without food.
Adults should take fosamprenavir oral suspension without food. Children should take the oral suspension with food. Shake fosamprenavir oral suspension vigorously before each use. If your child vomits within 30 minutes after taking a dose of fosamprenavir, the dose should be repeated.
Always take fosamprenavir in combination with other HIV medicines.
If you take too much fosamprenavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take fosamprenavir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What Should I Do if I Forget a Dose?
If you miss a dose of fosamprenavir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Fosamprenavir Cause?
Fosamprenavir may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDS_info_ fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of fosamprenavir can be serious. Serious side effects of fosamprenavir include severe skin reactions or rash. (See the WARNING box above.)
Other possible side effects of fosamprenavir include:
- Liver problems.
- Diabetes and high blood sugar (hyperglycemia).
- Changes in body fat (including gain or loss of fat).
- Changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
- Changes in blood test results. These include increases seen in liver function levels, blood fat levels, and decreases in white blood cells.
- Increased bleeding in some people with hemophilia.
- Kidney stones. Contact your health care provider right away if you have pain in your side, blood in your urine, or pain when you urinate.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of fosamprenavir. To learn more about possible side effects of fosamprenavir, read the drug label or package insert or talk to your health care provider or pharmacist.
The AIDS_info_ fact sheet on HIV Medicines and Side Effects also includes information that may apply to fosamprenavir.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.
How Should Fosamprenavir Be Stored?
- Store fosamprenavir tablets at room temperature, 68°F to 77°F (20°C to 25°C). Keep the bottle tightly closed.
- Store fosamprenavir oral suspension between 41°F and 86°F (5°C to 30°C). Refrigerating fosamprenavir oral suspension may improve its taste for some people. Do not freeze the oral suspension.
- Do not use fosamprenavir if the original seal over the container opening is broken or missing.
- Throw away fosamprenavir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep fosamprenavir and all medicines out of reach of children.
Where Can I Find More Information About Fosamprenavir?
More information about fosamprenavir is available:
- The fosamprenavir drug label, from DailyMed. The Patient Counseling Information section of the label includes information for people taking fosamprenavir.
- Fosamprenavir-related research studies, from the AIDS_info_ database of ClinicalTrials.gov study summaries.
- A list of FDA-approved HIV medicines, from AIDS_info_.
Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288
The above Patient Version drug summary is based on the following FDA label(s): Suspension, tablet (film coated).
[Note from TheBody.com: This article was created by AIDSinfo, who last updated it on Dec. 1, 2017. We have cross-posted it with their permission.]