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Selzentry (Maraviroc, Celsentri)

A New Way to Fight HIV: CCR5 Inhibitors

An Interview With David Hardy, M.D.

    When someone first becomes infected with HIV, about 98 percent to 99 percent of the time, whether it's sexual transmission, mother-to-child transmission, and in the majority of injection-drug-use transmissions, the type of HIV that causes infection is what's called a "CCR5-using virus." For short, we just call that an R5 virus.
    There is a type of HIV that is "bi," so to speak, meaning that it can use both the R5 lock-and-key mechanism and it can also use the X4 lock-and-key mechanism. We call those dual viruses. They can go either way, with R5 or with X4.

    Bonnie Goldman