Question

Dear Doctor, Thanks for all your responses on this site.

I had a recent exposure to HIV due to a condom failure during sex with an Escort of unknown HIV status.

The doctor put me on Truvada and Isentress. He said Isentress should take care of any resistant strains. I am tolerating the meds very well. I try to be very prompt about the meds, but is a 10 minute variation in taking the meds allowed?

How effective is this combination? Is this a 2 drug therapy or three-drug therapy? I had some pain during urination, so he put me on Cipro, even though my labs for urine samples on the second day of exposure for Chlamydia and Gonorreah were negative.

Thanks a lot. You are my savior....

Tanush

Answer

Hello Tanush,

Are you being followed by an HIV specialist? I recommend anyone who has had an HIV exposure significant enough to warrant a course of PEP be followed by an HIV specialist. That physician would and should address these types of very common concerns related to PEP. Briefly, a 10-minute variation in the timing of taking your meds is certainly not a problem. With your regimen, even an hour or two would not affect the efficacy of your treatment. We don't know the effectiveness of your specific regimen in the setting of PEP therapy, because Isentress has only recently been approved. During its pre-approval evaluation process, it was not studied specifically as a PEP agent. However, I see no reason why it would not be effective.

Truvada is a combination of tenofovir and emtricitabina. Consequently, you are on a three-drug PEP regimen.

Good luck.

Dr. Bob