Hi Dr. McGowan, thank you for your very important job. I am an anesthesia tech in NICU. I was assisting during lumbar tap of infant born to HIV+ mother. His mother was on antiretrivirals during pregnancy, and had undetectable (<50/mL) viral load so that she was eligible for normal vaginal delivery. Baby was also put on ZVD rigth after birth. I do not know his status. While providing anesthesia some of the meds splashed back into my eye (probably because of superficial needle insertion at the very beginning), and I not sure if it there was any blood. The vlume that I got into my face was ~0.2 ml. I washed my eye immediately and went to ED, where I was offered PEP with Retrovir+Kaletra for 28 days. I am just over with it and will have my test in 2 weeks. Q: what is the risk of getting infected via the rout I described? ER docs said that there are no documented evidence of seroconversion when exposed to eye, especially when the contaminant is even not a blood or biological fluid. Thank you for your answer in advance.


Sorry to hear about your experience. Yes, the risk of infection from this scenario is very, very low. Essentially theoretical. The facts that make it low risk are: undetectable viral load in the mother (most important), likely possibility that there was no blood contact, mucous membrane rather than percutaneous exposure. So it is not possible to quantify the risk with negligible exposure. I am glad you were able to tolerate the meds and encourage you to follow up to complete the testing to put this incident behind you.

A great link to the current guidelines is via the CDC:

or to speak to a person call the PEP line: 1-888-448-4911, 24 hours/7 days a week.

Best, Joe