Drug Interactions between Levitra and HIV/depression meds?

Question

I have been HIV+ for 3 years and I am on the current med regimen:

Viramune 200 mg po BID Epivir 150 mg po BID Zerit 40 mg po BID Valtrex 500 mg po daily Testosterone 200 mg IM q week Nandralone Deca 100 mg IM q week Lexapro 1.5 mg po qAM Wellbutrin XL 150 mg po qAM Risperdal 1.5 mg po bedtime Trazadone 100 mg po bedtime Viagra 50 mg po 30 min before sexual activity

I've asked my MD about switching my viagra for erectile dysfunction (not using it recreationally) to Levitra, but she's nervous about not having much information about drug interactions. Are you aware of any interactions or potential interactions with any of my other meds?

As you can tell, my psych meds are complicated simply because of the various adverse effects I suffer from taking anti-depressants, but it beats being dead. It's always a tricky balance, and I'd hate to mess that up or cause a change in my viral load and/or CD4 count. My viral load is undetectable and my CD4's are 700-800.

Thanks, JC in SF,CA

Answer

Levitra has a potential drug interaction with protease inhibitors, which can elevate levels of Levitra, and require starting on a lower dose than usual. However, you are not taking a protease inibitor. Your ART regimen is based on Viramune, an NNRTI.

I would not anticipate any clinically significant drug interaction by switching from Viagra to Levitra.