Creatine 1.7 and increasing

Question

In January of 2014 my creatine level increased to 1.32 and HIV regimine that I had been on since diagnosis in 2007 of Truvada, Reyataz and Norvir was changed to Reyataz, Norvir & Epzicom. Creatine levels have slowly increased and again my medications were changed in April 2015 to Triumeq, one pill regimine. I had to seek out my lab results online and creatine level was 1.7. What can I do to lower this figure? Does it really mean that it is stage 2 of renal failure? I have read this on several internet articles.

Answer

The Dolutegravir in Triumeq has been shown to increase serum creatinine because it blocks tubular secretion of creatinine, but doesn't usually affect kidney function. Thus, this may be an artifact of the new med combo and not actual kidney injury. I suggest you discuss this with your doctor and bring in a nephrologist if necessary.