Can Tivicay and Truvada cause depression?


Dear doctor,

Im diagnosed and taking truvada and tivicay since 3 years. Undetectable, all results are great, no side effect etc. Now I'm originally a very positive person and can handle quite good the negative experiences in my life, I have a strong character and see the many good things in life. But I have more and more too many negative thoughts without any explanation,see everything sooo bad and hopeless I cannot explain!also totally crazy nightmares I never had before! Would it be possible that is because of these medications and if yes what could I do? I cannot believe my character changed as I said I dealed already other problems good.

Thank you for your answer.


Hello and thanks for writing,

Like many HIV medications, Tivicay (dolutegravir) does carry the risk of psychiatric symptoms ranging from insomnia to depression. It is generally well-tolerated but does carry some risk (although low) in one recent study of patients taking Tivicay, 6% experienced insomnia and sleep disturbance and 4-5% experienced depression.

As for Truvada, each of the component drugs can cause psychiatric symptoms. With emtricitabine, insomnia and abnormal dreams are very common (10% or more), as are dizziness and headache. Symptoms of depression are also very common (10% or more) with Tenofovir.

Since you have experienced such a change in your level or emotional resilience and you are experiencing significant sleep disturbance after starting these drugs I think it is definitely worth reporting these symptoms to your physician. Fortunately today we have many medication options although switching drugs may have other trade-offs. Your doctor will be your best advisor.

You may also want to consider consulting a mental health practitioner who could provide you with some useful tools to cope with the depressive symptoms.

Wishing you all the best,