Brand Name: Delstrigo
Other Name(s): DOR/3TC/TDF, doravirine/lamivudine/TDF, doravirine/lamivudine/tenofovir DF
Drug Class: Combination Drugs
Delstrigo can cause serious, life-threatening side effects. These include kidney problems, including kidney failure, and bone problems such as bone pain, softening or thinning (which may lead to fractures).
Contact your health care provider right away if you have any of the following symptoms that could be signs of a kidney or bone problem:
- Bone pain that does not go away or worsening bone pain
- Pain in your arms, legs, hands, or feet
- Broken (fractured) bones
- Muscle pain or weakness
If you have both HIV and hepatitis B virus infection (HBV) and take Delstrigo, your HBV may get much worse (flare up) if you stop taking Delstrigo. Do not stop taking Delstrigo without first talking to your health care provider.
While taking Delstrigo, it is important to keep all your appointments with your health care provider.
What Is Delstrigo?
Delstrigo is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who have never used HIV medicines. Delstrigo is a complete regimen for the treatment of HIV infection and should not be used with other HIV medicines.
Delstrigo contains the following three different medicines combined in one pill:
- Doravirine -- an HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI)
- Lamivudine -- an HIV medicine called a nucleoside reverse transcriptase inhibitor (NRTI)
- Tenofovir disoproxil fumarate -- an HIV medicine that is also an NRTI
Both NNRTIs and NRTIs block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, the three drugs combined in Delstrigo prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Delstrigo, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
What Should I Tell My Health Care Provider Before Taking Delstrigo?
Before taking Delstrigo, tell your health care provider:
- If you are allergic to any of the HIV medicines in Delstrigo (doravirine, lamivudine, and tenofovir disoproxil fumarate) or any other medicines.
- If you have or have ever had hepatitis B virus infection (HBV).
- If you have or have ever had kidney problems.
- If you have or have ever had bone problems, including a history of bone fractures.
- If you have any other medical conditions.
- If you are pregnant or plan to become pregnant. Whether Delstrigo can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking Delstrigo when pregnant.
- If you are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV or are taking Delstrigo.
- If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the AIDSinfo HIV and Birth Control infographic.
- About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Delstrigo may affect the way other medicines or products work, and other medicines or products may affect how Delstrigo works. Taking Delstrigo together with certain medicines or products may cause life-threatening side effects.
How Should I Take Delstrigo?
Delstrigo comes in tablet form. Each tablet contains:
- 100 mg doravirine (brand name: Pifeltro)
- 300 mg lamivudine (brand name: Epivir)
- 300 mg tenofovir disoproxil fumarate (brand name: Viread)
Take Delstrigo according to your health care provider's instructions.
Take Delstrigo with or without food.
If you take too much Delstrigo, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Delstrigo, see the FDA drug label.
What Should I Do if I Forget a Dose?
If you miss a dose of Delstrigo, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Delstrigo Cause?
Delstrigo may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Delstrigo can be serious. Serious side effects of Delstrigo include kidney and bone problems. (See the WARNING box above.)
Another possible side effect of Delstrigo is changes in your immune system (called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Delstrigo. To learn more about possible side effects of Delstrigo, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA MedWatch at 1-800-FDA-1088 (1-800-332-1088) or online.
How Should Delstrigo Be Stored?
- Store Delstrigo at room temperature, 68°F to 77°F (20°C to 25°C).
- Keep Delstrigo in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture. Keep the desiccant in the container and do not eat the desiccant.
- Do not use Delstrigo if the original seal over the container opening is broken or missing.
- Throw away Delstrigo that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Delstrigo and all medicines out of reach of children.
Where Can I Find More Information About Delstrigo?
More information about Delstrigo is available:
Merck & Co., Inc.
Main number: 877-888-4231
Patient assistance: 800-444-2080
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
[Note from TheBody: This article was created by AIDSinfo, who last updated it on Aug. 31, 2018. We have cross-posted it with their permission.]