3 part question on resistance.

Question

I take trizivir and sustiva. Will I eventually resist these drugs? If so, is there any prediction as to when that happens?

In that case do I just try new drugs?

Answer

Loss of viral suppression and the development of resistance largely results today from adherence issues. If you are on that regimen and have an undetectable level of viral load, you could stay on that regimen for years without any loss of effect or the development of resistance. If your viral load does begin to reappear a resistance test would be ordered to determine which meds in the combo you may have become resistant to. If that happens, then yes, you would be switched to something else that is active.