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Interleukin
The Basics
- Interleukin-2 (IL-2, Proleukin) (March 2007)
To read PDF, click here
From Project Inform
- IL-2 (August 15, 2006)
From AIDS Treatment Data Network
- Interleukin-2 (April 2, 2006)
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From AIDS InfoNet
- The Development Pipeline for Cytokines, Immunomodulators and Gene Therapy (September 29, 2005)
In TAGline, from Treatment Action Group
- An Overview of Aldesleukin (IL-2, Proleukin) (March 10, 2004)
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From U.S. National Institutes of Health
- Update on IL-2: Where It's Been and Where It's Going (June 2002)
Signs increasingly suggest that the drug may finally be approved within the next few years.
In The PRN Notebook
- IL-2: Promiscuous Cytokine or Steady Date? (Winter 2001/2002)
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In ACRIA Update, from AIDS Community Research Initiative of America
- The Role of IL-10 in Long-Term Non-Progressors (Winter 2001/2002)
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In ACRIA Update, from AIDS Community Research Initiative of America
- The Resource Train: "Lunch and Learn": Dr. Melanie Thompson Sheds Light on IL-2 (August 2001)
In Survival News, from AIDS Survival Project
- What's New With IL-2? (January 2001)
In Hopkins HIV Report
- What Are Interleukins? (From BETA) (Fall/Winter 2000)
In Women Alive Newsletter, from Women Alive
- Interleukin 2 and Immune Reconstitution (July 25, 2000)
In Journal of the American Medical Association
- Interleukin 2 Treatment for HIV Infection (July 12, 2000)
In Journal of the American Medical Association
- Maintain Your T-cell Count, and Get More T-cells (May 1, 2000)
In Reasons for Hope, from Search for a Cure
- Interleukin-2: Use in Immune Restoration and During Structured Treatment Interruption (March 2000)
In The PRN Notebook
- Immune-Based Therapies (Fall 1999)
In Women Alive Newsletter, from Women Alive
- Turn on Your Body -- Mobilize the Immune System (April 1999)
In Survival News, from AIDS Survival Project
- IL-2 Taken to HAART (February 1999)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Interleukin-2 (IL-2): A Path Toward Functional Eradication? (December 1998)
In Project Inform Perspective, from Project Inform
- Interleukin-2: The Saga Continues (October 1998)
In HIV Newsline, from San Francisco General Hospital
- IL-2 for HIV: The Long March Toward FDA Approval (September 1997)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Immune Modulation Therapy with IL-2 and IL-12 (Winter 1996/1997)
In STEP Perspective, from Seattle Treatment Education Project
Open Trials
Trial Results
- Interleukin-2 Ineffective in Maintaining Baseline CD4+ Cell Count During Treatment Interruption (February 6, 2008)
From The Body PRO
- TILT: A Look at the Role of Interleukin-2 in Treatment Interruption Leans Toward the Negative (February 28, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Interleukin-2 Expands Select CD4+ T-Cell Populations, but Has No Effect on HIV-Specific Immune Responses (February 26, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Scientists Explore Possible New Way to Fight AIDS (February 8, 2007)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Comparing a Treatment Interruption With or Without Interleukin-2 in Delaying a Falling CD4+ Cell Count (February 25, 2005)
In The 12th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- HIV Patients Get Long-Term Boost With Short, Intermittent Drug Regimen (April 26, 2004)
From U.S. National Institute of Allergy and Infectious Diseases
- Immunological and Virological Efficacy of ALVAC-VIH 1433 and HIV Lipopeptides (Lipo-6T) Combined With SC IL-2 in Chronically HIV-Infected Patients -- Results of the ANRS 093 Randomized Study (February 12, 2003)
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- IL-2 & CD4 T Cells: Number & Function Disconnect? (January/February 2003)
In TAGline, from Treatment Action Group
- Interleukin-2 (IL-2, Proleukin) and Immune Function (January 2003)
Research from the 2002 International AIDS Conference.
To read PDF, click here
In Project Inform Perspective, from Project Inform
- Setback for Validation of IL-2 (November 2002)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Baseline Characteristics Associated With CD4+ Response After Three Cycles of Subcutaneous (SC) Recombinant Human Interleukin-2 (IL-2) (February 25, 2002)
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Intermittent IL-2 Administration in HIV Infected Patients Leads to a Decrease in CD4+ T Cell Turnover Rates (July 10, 2001)
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- Interleukin-2 Improves CD4+ Cell Counts in Patients with Poor Immune Response to HAART (April 2001)
In HIV Treatment Bulletin
- Experimental Immune Modulator Drugs (Spring 2001)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
- A Randomized Trial of Interleukin-2 (IL-2) Added to HAART for Primary HIV (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Extended Therapy with Subcutaneous Interleukin-2 (scIL-2) in HIV-Infection: Long-Term Follow-Up of 3 Trials (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Immunomodulation of Chronic HIV-1 Infection: Impact of HAART, Interleukin-2 and/or an Inactivated gp120-Depleted HIV-1 Immunogen (REMUNE) (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Prediction of CD4+Cell Response to Subcutaneous Recombinant Interleukin-2 (SCrIL-2) (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Prospective, Randomized, Controlled Phase II Study of Highly Active Antiretroviral Therapy (HAART) with Continuous IV (CIV) or Subcutaneous (SC) Interleukin-2 (IL-2) in HIV-Infected Patients with CD4+Counts of 50 -- 350 cells/mm3: ACTG 328 -- Final Result (February 5, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Update: Subcutaneous Interleukin-2 (February 2001)
In HIV Newsline, from San Francisco General Hospital
- Interleukin-2 May Help Patients with Advanced HIV Disease, New Study Shows (October 25, 2000)
From U.S. National Institute of Allergy and Infectious Diseases
- Il-2's Effect on Viral Load (October 10, 2000)
STEP's coverage of the 40th ICAAC Conference.
In STEP Ezine, from Seattle Treatment Education Project
- Immunologic and Virologic Effects of Subcutaneous Interleukin 2 in Combination With Antiretroviral Therapy: A Randomized Controlled Trial (July 12, 2000)
In Journal of the American Medical Association
- Adding IL-2 to Potent Anti-HIV Drugs Increases CD4+ T-Cell Counts Without Raising HIV Levels (July 8, 2000)
From U.S. National Institute of Allergy and Infectious Diseases
- Immune-Based Therapies in Brief (April 2000)
In Project Inform Perspective, from Project Inform
- Cessation of HAART Plus Daily Low-Dose Interleukin 2 to Promote Immunity to HIV (January 31, 2000)
In The 7th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Rapid Rebound of HIV and Reappearance of HIV Reservoirs in Patients Treated with IL-2 and Combination Antiretroviral Drugs Following Cessation of Therapy (October 27, 1999)
From U.S. National Institute of Allergy and Infectious Diseases
- Efficacy of Low-Dose Subcutaneous Interleukin-2 to Treat Advanced Human Immunodeficiency Virus Type 1 in Persons with 250/µL CD4 T Cells and Undetectable Plasma Virus Load (July 1999)
In Journal of Infectious Diseases
- A Randomized Controlled Multicenter Phase II Trial of Subcutaneous Interleukin-2 (scIL-2) Therapy in HIV-Infected Patients with CD4 Counts 200-500 cells/µL (February 2, 1999)
In The 6th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Treatment with IL-2 Plus HAART Markedly Reduces HIV in Immune System "Hiding Places" (November 15, 1998)
From U.S. National Institute of Allergy and Infectious Diseases
- IL-2: Controlled Trial Finds Major CD4 Increases (November 1996)
In AIDS Treatment News, from AIDS Treatment News
- Study: Interleukin 2 Boosts Immunity of AIDS Patients (October 1996)
From CNN
- Feckless IL-2 Researchers Plod Ahead (November 1994)
In TAGline, from Treatment Action Group
Interviews with Doctors
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