Specific HIV Medication Interactions

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General

ARV Alert (Regularly Updated)
Periodic updates on newly announced interactions involving HIV medications; each update features a brief synopsis of the interaction, as well as a chart outlining key information.
From HIV InSite
Warnings About Taking Reyataz With Sustiva, Viramune, Oral Contraceptives (August 21, 2008)
From U.S. Food and Drug Administration
Patient Information About Reyataz (Atazanavir) (PDF) (December 2007)
From Bristol-Myers Squibb Company
Acid-Reducing Agents Reduce Atazanavir Drug Levels but Not Lopinavir/Ritonavir Levels (February 7, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections
French Study Questions Interaction Between Atazanavir and Antacids (October 24, 2005)
From aidsmap.com
ddI + Ribavirin May Cause Mitochondrial Toxicity (September 1, 2005)
In Journal of Acquired Immune Deficiency Syndromes
Efavirenz Reduces Plasma Levels of Popular Statins (July/August 2005)
From The Body PRO
Antacids and HIV Medications (May/June 2005)
Over-the-counter antacids like Mylanta, Rolaids and Tums can decrease blood levels of some HIV meds.
In Survival News, from AIDS Survival Project
Notice of Important New Drug Interactions With Norvir, Kaletra (March 30, 2005)
New interactions noted with fluticasone (a component of Flonase nasal spray) and trazodone (Desyrel, an antidepressant).
From U.S. Food and Drug Administration
Drug Interaction Warning: Saquinavir/Ritonavir and Rifampin (Rifampicin, Rifadin, Rimactane, Rofact) (February 8, 2005)
To read PDF, click here
From U.S. Food and Drug Administration
Don't Combine Fosamprenavir and Lopinavir/Ritonavir (February/March 2005)
From The Body PRO
Do Not Combine Reyataz and Prilosec: News Summary (December 31, 2004)
In AIDS Treatment News, from AIDS Treatment News
Atazanavir, With or Without Ritonavir, Should Not Be Coadministered With Proton Pump Inhibitors (December 20, 2004)
From U.S. Food and Drug Administration
Warning Against Using Erythromycin (Even Orally) While Using Protease Inhibitors or Certain Other Drugs (October 26, 2004)
A study finds an increased risk of sudden death from cardiac causes.
In AIDS Treatment News, from AIDS Treatment News
ddI + Tenofovir Combination Linked to Higher Pancreatitis Risk (October 2004)
Quick recap of a report in The Lancet.
In HIV Treatment ALERTS!, from The Center for AIDS
Interaction Reported Between Grapefruit Juice and Statins (October 2004)
This interaction may also worsen other interactions between statins and HIV medications.
In HIV Treatment ALERTS!, from The Center for AIDS
Genetics Influence Response to HAART and Incidence of Pancreatitis, Studies Show (August 3, 2004)
From aidsmap.com
Changes to Labeling for Desyrel (Trazodone Hydrochloride) Tablets (PDF) (May 2004)
A "Dear Healthcare Professional" letter on potential interactions between this antidepressant and CYP3A4 inhibitors such as indinavir and ritonavir.
From U.S. Food and Drug Administration
Non-Antiretroviral Medication-Related Adverse Events During Treatment of HIV-Related Infections and Complications (May 2004)
From HIV InSite
Atazanavir (Reyataz): New Recommendations if Combined With Tenofovir (Viread) -- and Warning on Viagra, Cialis, and Levitra (March 26, 2004)
New warnings on drug-drug interactions are noted in the prescribing information for atazanavir.
In AIDS Treatment News, from AIDS Treatment News
Atazanavir/Tenofovir Combo Should Be Boosted With Ritonavir (August 8, 2003)
From U.S. Food and Drug Administration
HIV-Positive Man Dies of Kidney Failure and Lactic Acidosis Due to Tenofovir/ddI Interaction (April 8, 2003)
From aidsmap.com
Herbs, Supplements and HIV: Drug Interactions (April 2003)
To read PDF, click here
From Project Inform
Tenofovir DF and Didanosine EC: Investigation of Pharmacokinetic Drug-Drug and Drug-Food Interactions (November 21, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
Intracellular Metabolism of AZT Leads to the Production of Significant Levels of d4T Triphosphate in HIV Infected Patients (November 19, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
New Safety Information -- Viread Co-Administration With Videx (September 30, 2002)
From U.S. Food and Drug Administration
Viread-Videx EC Drug Interactions -- What's a Person to Do? (Fall 2002)
To read PDF, click here
In STEP Perspective, from Seattle Treatment Education Project
New Safety Information for Videx (Didanosine, ddI) Used With Ribavirin (September 25, 2002)
From U.S. Food and Drug Administration
Drug Interactions Need More Attention (January 25, 2002)
To read PDF, click here
In AIDS Treatment News, from AIDS Treatment News
Caution With Nelfinavir and Some Lipid-Lowering Drugs (November 21, 2001)
From Canadian AIDS Treatment Information Exchange
Bizarre Side Effects From an Interaction Between Nevirapine and Clarithromycin (August 17, 2001)
From Canadian AIDS Treatment Information Exchange
Women and Pharmacology (March 2001)
To read PDF, click here
In Project Inform Perspective, from Project Inform
Risk of Interactions Between Zyban & HAART (March 5, 2001)
From aidsmap.com
Drug Transporter, Drug Concentrations, and Drug Interactions (March 1, 2001)
In Hopkins HIV Report
Drug Interactions of Protease Inhibitors and Psychiatric Medications (January 2001)
In Survival News, from AIDS Survival Project
Caution Advised When Using Cipro With Methadone (December 20, 2000)
From Canadian AIDS Treatment Information Exchange
Methadone Interferes With Some Formulations of ddI (September 8, 2000)
From Canadian AIDS Treatment Information Exchange
Protease Inhibitors Interact With Some Sleeping Pills (August 31, 2000)
From Canadian AIDS Treatment Information Exchange
Ritonavir and PI-Boosting: Using Drug/Drug Interactions to Our Advantage (July 14, 2000)
In STEP Ezine, from Seattle Treatment Education Project
Selected Highlights From the 7th CROI: Drug Interaction and Side Effect Studies (Spring 2000)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
What You Should Know About Mixing Cocktails (Spring 2000)
In STEP Perspective, from Seattle Treatment Education Project
Drug Interaction and the Anti-HIV Drug Emivirine (Coactinon) (December 1999)
From Project Inform
Drug Interactions Studied at ICAAC (November 1999)
In Positive Living, from AIDS Project Los Angeles
FDA Strengthens Warning Label for Propulsid (June 29, 1998)
Heartburn drug may interact with protease inhibitors.
From U.S. Food and Drug Administration
Efavirenz (Sustiva, DMP 266) and Saquinavir (Fortovase) Combination: Pharmacologic Interaction (June 5, 1998)
From AIDS Treatment News
Drug Interactions Associated With Protease Inhibitors (May 1998)
In Positive Living, from AIDS Project Los Angeles
Drug Interactions: Another Complication in HIV Care (April 1998)
In Positive Living, from AIDS Project Los Angeles
Drug Interactions: Resources for Patients and Professionals (March 6, 1998)
In AIDS Treatment News, from AIDS Treatment News
Drugs That May Interact With Protease Inhibitors via CYP3A4 Metabolism (December 18, 1997)
In Protease Inhibitors Backgrounder, from U.S. Food and Drug Administration
Effects of Protease Inhibitors and Other Commonly Used Medications as Determined by Drug Interaction Studies (December 18, 1997)
In Protease Inhibitors Backgrounder, from U.S. Food and Drug Administration
Medications That Should Not Be Used With Protease Inhibitors (December 18, 1997)
In Protease Inhibitors Backgrounder, from U.S. Food and Drug Administration
Protease Inhibitor Drug Interactions: What Do Patients Need to Know? (August 27, 1997)
An edited transcript of a BETA Live! conference call broadcast.
From San Francisco AIDS Foundation
Book Review of "Powers and Moore's Food-Medications Interactions" (May 1997)
In Journal of the International Association of Physicians in AIDS Care, from International Association of Physicians in AIDS Care
Medications Contraindicated With the Use of Ritonavir (April 3, 1996)
In TAGline, from Treatment Action Group

St. John's Wort

St. John's Wort Interferes With Chemotherapy, Study Shows (August 31, 2002)
The herb is found to dramatically decrease blood levels of a key cancer-fighting drug.
In British Medical Journal
St. John's Wort Found to Lower Nevirapine Levels (March 2, 2001)
From Canadian AIDS Treatment Information Exchange
NIH Study Cautions Use of St. John's Wort With Anti-HIV Drugs (April 2000)
In Project Inform Perspective, from Project Inform
St. John's Wort Warning: Do Not Combine With Protease Inhibitors, NNRTIs (February 18, 2000)
From AIDS Treatment News
NIH Clinical Center Study Demonstrates Dangerous Interaction Between St. John's Wort and an HIV Protease Inhibitor (February 10, 2000)
From U.S. National Institutes of Health
Treatment Briefs: St. John's Wort Lowers Indinavir (and Possibly Other) Drug Levels (Winter 1999/2000)
In GMHC Treatment Issues, from Gay Men's Health Crisis

Viagra

The Dangers of Using and Abusing Viagra (November/December 2004)
In Survival News, from AIDS Survival Project
Viagra and Grapefruit Juice -- Not a Good Mix (February 12, 2002)
From Canadian AIDS Treatment Information Exchange
Viagra: New Warning With Protease Inhibitors (May 7, 1999)
From AIDS Treatment News
Protease Inhibitors, Sexual Dysfunction, and Viagra (March 1999)
Pfizer issues an alert.
In GMHC Treatment Issues, from Gay Men's Health Crisis

Cholesterol-Lowering Medications (Statins)

Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers. (February 14, 2008)
In Journal of Acquired Immune Deficiency Syndromes
Efavirenz Reduces Plasma Levels of Popular Statins (July/August 2005)
From The Body PRO
Interaction Reported Between Grapefruit Juice and Statins (October 2004)
This interaction may also worsen other interactions between statins and HIV medications.
In HIV Treatment ALERTS!, from The Center for AIDS
New Guidelines for the Use of Cholesterol-Lowering Drugs With HAART (September 7, 2000)
In STEP Ezine, from Seattle Treatment Education Project
"Statin" Drugs May Interact With Protease Inhibitors (March 2000)
In What's New, from Project Inform
Potential Interactions Between Cholesterol Lowering Drugs and Protease Inhibitors (September 1998)
In Notes From the Underground, from PWA Health Group
A Further Point About Statins ... (June 1998)
Caution needed when using drugs to treat elevated cholesterol while on protease inhibitors.
In GMHC Treatment Issues, from Gay Men's Health Crisis

Birth Control Pills

Antiretroviral Medications and Oral Contraceptive Agents (2007)
From Clinical Manual for Management of the HIV-Infected Adult.
In Canadian Medical Association Journal, from AIDS Education & Training Centers National Resource Center
High Dose of Vitamin C Significantly Reduces Indinavir Levels in Pilot Study (September 16, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
Viramune Affects Birth Control in HIV+ Women (March 31, 2000)
In STEP Ezine, from Seattle Treatment Education Project
Pregnant Pause (Summer 1998)
Interaction between antiretrovirals and birth control pills.
In STEP Perspective, from Seattle Treatment Education Project

Vitamins

Vitamin A (Beta Carotene and Retinoids) and HIV Drug Interactions (January 2003)
Research from the 2002 International AIDS Conference.
In Project Inform Perspective, from Project Inform
Vitamin E, Vitamin A and Anti-HIV Therapies (January 2003)
Research from the 2002 International AIDS Conference.
In Project Inform Perspective, from Project Inform

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