Question:
Since we have changed my treatment regime and added d4T and Ritonavir (to Saquinavir and ddI), my liver enzymes,
formerly normal, rise to yGT 170, GPT 80, GOT40, AP also slightly elevated. Tendency is still slowly increasing. Do You
think, that Ritonavir/Saquinavir or d4T induces these liver enzymes? Thank you for an answer! Alexander
Loschmann/Germany
Dr. Torres' Response:
Of the drugs you are on both saquinavir and ritonavir can cause elevation in
liver function tests; you must follow the LFTs closely and it is usually is
recommended that the drugs be interrupted if they rise five times above the
limit of normal (in the case of transaminases this is usually around 200
units/ml).
Ramon Torres, MD
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