December 2006

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C O N T E N T S Why Is Understanding Drug Resistance Important? How HIV Works HIV Mutations HIV Treatment How Drug Resistance Occurs How Does Resistance Affect Your Treatment Options? Checking for Resistance Resistance Testing: Finely Targeting Your Drugs Who Should Get a Resistance Test? Types of Resistance Tests Genotypic Tests Phenotypic Tests Virtual Phenotypic Tests What Exactly Is a Mutation? Meet the Mutations: A Class-by-Class Breakdown How Fit Is Your Virus? How Can You Avoid Resistance? The Bottom Line S A M P L E   R E S I S T A N C E T E S T S   A N D   A N A L Y S I S Genotypic Test Phenotypic Test Virtual Phenotypic Test

Consult your doctor! The only purpose of this booklet is to educate and to inform. It is no substitute for professional care by a doctor or other medical professionals. Body Health Resources Foundation neither endorses nor opposes any particular treatment option discussed in this booklet. Instead, we encourage you to discuss your options with a healthcare provider who specializes in treating HIV.

We would like to thank Cal Cohen, M.D., M.S., Mark Holodniy, M.D., F.A.C.P., C.I.C., Gerald Pierone Jr., M.D., and David Wohl, M.D., for generously providing medical reviews of this booklet. Funding for this booklet comes in part from an educational grant provided by Boehringer Ingelheim Pharmaceuticals, Inc.

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