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Prezista's Resistance Profile
Which mutations is Prezista resistant to?
Response from Renslow Sherer, M.D. (October 9, 2006)
Should Prezista Be Used as a First-Line Treatment?
I was diagnosed with HIV six weeks ago, after being admitted to the hospital for PCP. My doctor has asked me to join a clinical trial for Prezista aimed at treatment-naive people. I have read that Prezista is very useful for treatment-experienced patients, but is it a good option for someone like me?
Response from Benjamin Young, M.D., Ph.D. (August 15, 2006)
Is Prezista "Bulletproof"?
I'd like to know what percentage of people in clinical trials for Intelence and Prezista experienced virological failure. I've heard those drugs are supposed to be "bulletproof" but not quite "bombproof." Is that about right?
Response from Eric Daar, M.D. (June 10, 2006)
Am I Already Resistant to Prezista and Intelence?
I have been taking Prezista and Intelence (etravirine) for several months as part of the Tibotec DUET study. At first I responded well. My viral load went from 250,000 to 25,000 and my CD4 count went from 6 to 26. Now my labs show a viral load of 47,000 and a T-cell count of 15. Is this evidence that I've already become resistant to the drugs?
Response from Renslow Sherer, M.D. (April 27, 2006)
Are Fuzeon and Prezista Really My Only Options?
I've been on treatment for HIV for 21 years. In the past year my viral load has been doubling every three months, and my CD4 count has fallen to 150. My last phenotype test showed that I am resistant to a long list of drugs, and my doctor says Fuzeon (enfuvirtide, T-20) and Prezista are my only choices left. Could that be true?
Response from David Wohl, M.D. (September 21, 2006)
Can I Switch From Viread to Prezista to Avoid Renal Toxicity?
For over three years I have taken Epivir (lamivudine, 3TC), Viread (tenofovir), Reyataz (atazanavir) and Norvir (ritonavir). My viral load is undetectable and my CD4 count is 400, but I would like to switch away from Viread because I'm concerned about renal toxicity. Would a combination of the protease inhibitors Reyataz and Prezista and the nucleoside reverse transcriptase inhibitor Epivir be a sound regimen?
Response from Robert J. Frascino, M.D. (May 14, 2006)
Prezista and Testosterone
Two months ago I began taking Prezista, Truvada (tenofovir/FTC) and Norvir (ritonavir). The drugs have been amazingly effective, but I've noticed that my testosterone level has skyrocketed along with my CD4 count. Although I use testosterone gel to combat fatigue, my testosterone levels have usually been somewhat low. Once the meds change was initiated, my testosterone count jumped to 2,400. Could my new meds have caused the spike?
Response from Eric Daar, M.D. (October 9, 2006)
Can Prezista Cause Pancreatitis?
My doctors believe I developed pancreatitis as a result of taking Fuzeon and Prezista (darunavir, TMC114) over the last eight months. Have you heard of this and do you know what, if any, foods I should avoid to help the pancreas recover?
Response from Keith Henry, M.D. (September 17, 2006)
Should Someone With a Penicillin Allergy Take Prezista?
I'm allergic to penicillin. Furthermore, I seem to have developed mutation K103 while on Sustiva. I'm currently taking Truvada and Sustiva. My doctor wants to remove the Sustiva and add Prezista (darunavir, TMC114). I have recently learned that Prezista is a sulfa drug, and is perhaps dangerous to someone with allergies to other sulfa drugs. Am I at risk?
Response from Benjamin Young, M.D. (September 14, 2006)
What Are the Chances My Prezista Side-Effects Will Go Away Soon?
I've been on Prezista [along with Norvir (ritonavir), Reyataz (atazanavir) and Truvada (tenofovir/FTC)] for two weeks and had diarrhea, nausea, vomiting and headaches ever since. My doctor wants me to stick it out for another week or two to see if the side effects get better, but I'm sick of feeling sick! Is it really likely that my side effects will subside?
Response from Keith Henry, M.D. (February 9, 2006)