Prezista (Darunavir, TMC114)
| Brand Name: |
Prezista |
| Generic Name: |
darunavir, TMC114 |
| Adult Single Dose: |
800 mg (two 400-mg tablets) taken with Norvir 100 mg once daily
For those with at least one darunavir resistance associated substitution: one 600-mg tablet taken with Norvir 100 mg twice daily |
| Food & Liquid Restrictions: |
Take with food |
| Drug Class: |
PI |
The Basics
- An Overview of Prezista (Darunavir, TMC114) (March 5, 2013)
From AIDSinfo
- Patient Information About Prezista (Darunavir, TMC114) (PDF) (February 2013)
From Janssen Pharmaceuticals, Inc.
- Darunavir (Prezista) (December 8, 2012)
To read PDF, click here.
From AIDS InfoNet
- Prezista (March/April 2012)
To read PDF, click here.
In Positively Aware, from Test Positive Aware Network
- FAQs About Prezista (Darunavir) (February 1, 2012)
From The Body's "Ask the Experts" Forums
- Prezista (Darunavir, TMC-114) (September 28, 2007)
Basic information on dosing schedules and side effects.
From U.S. Department of Veterans Affairs
- An Interview With Cal Cohen, M.D., a Lead Investigator of the Darunavir (TMC114, Prezista) POWER Trials (June 28, 2006)
Dr. Cohen discusses TMC114's uses, adverse effects and other considerations.
- Prezista Approval (June 23, 2006)
From U.S. Food and Drug Administration
News
- Prezista (Darunavir) Label Change -- Drug Interaction Information (March 1, 2013)
From U.S. Food and Drug Administration
- New 800-mg Prezista (January/February 2013)
To read PDF, click here.
In Positively Aware, from Test Positive Aware Network
 The 800-mg Darunavir Tablet Arrives, and Scoring the Top Protease Inhibitors (November 18, 2012)
From Journal Watch
On TheBodyPRO.com
- Much More Than Just Following Your Doctor's Orders (July 12, 2012)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- FDA Approve Pediatric Dose for Darunavir (January/February 2012)
To read PDF, click here.
In HIV Treatment Bulletin, from HIV i-Base
- Updated Information About Prezista (Darunavir): Oral Suspension and Labeling Changes (December 20, 2011)
From U.S. Food and Drug Administration
- Gilead and Tibotec Agree on New Single-Tablet Regimen (November 23, 2011)
In Positively Aware, from Test Positive Aware Network
- Gilead and J&J Expand HIV Cocktail Partnership (November 16, 2011)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Tibotec and Gilead Team Up to Develop Prezista/Cobicistat Combo (July 5, 2011)
From Test Positive Aware Network
- Musty Smell Forces Johnson & Johnson to Recall HIV/AIDS Drug (May 12, 2011)
In Los Angeles Times
VIEW ALL ARTICLES
Research
- Resistance to Darunavir Falling Since Approval of the Protease Inhibitor in 2006 (March 11, 2013)
From National AIDS Treatment Advocacy Project
- Darunavir/Ritonavir and Etravirine as a Prevention Method Is Biologically Plausible (Summer 2012)
To read PDF, click here.
In Being Alive Newsletter, from Being Alive
On TheBodyPRO.com
- Darunavir Use During Pregnancy (May/June 2012)
To read PDF, click here.
In HIV Treatment Bulletin, from HIV i-Base
On TheBodyPRO.com
 Top 10 HIV/AIDS-Related Clinical Developments of 2011 (December 1, 2011)
David Alain Wohl, M.D., on HIV treatment as prevention; the dawning of pre-exposure prophylaxis (PrEP), but with women absent; the concept of "viremia copy-years"; the impact of race and gender on HIV treatment outcomes; setbacks for two treatment approaches involving Isentress; new hepatitis C therapies; a new once-daily HIV pill; the rising rates of HIV among black MSM; and what comes after "test and treat."
From TheBody.com
- Pharmacokinetics of Darunavir and Fosamprenavir in Pregnancy (July/August 2011)
To read PDF, click here.
- Another NRTI-Sparing Regimen Does Well in Treatment-Naive Patients (July 25, 2011)
From aidsmap.com
- Novel Mutations and Shifting Susceptibility to Darunavir and Tipranavir (September 15, 2010)
From National AIDS Treatment Advocacy Project
- Metabolic Marker Changes Similar After 12 Weeks of Darunavir and Atazanavir (July 26, 2010)
From National AIDS Treatment Advocacy Project
- Lessons From GRACE: A U.S. Study Focused on Women Living With HIV (June 2010)
From The Well Project
- Odin -- Darunavir-Ritonavir Once or Twice Daily (March/April 2010)
To read PDF, click here.
In Treatment Update, from Canadian AIDS Treatment Information Exchange
VIEW ALL ARTICLES
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Glossary
