Structured HIV/AIDS Treatment Interruptions: Research/Trial Results
- Treatment Interruption Revisited (Winter/Spring 2009)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
- Treatment Interruption Uncovers HIV's Attack on the Kidneys (February 2009)
To read PDF, click here
In Treatment Update, from Canadian AIDS Treatment Information Exchange
- Markers of Inflammation and Blood-Clotting Tied to Hazards of Intermittent HIV Treatment (October 21, 2008)
From National Institute of Allergy and Infectious Diseases
- Markers of Inflammation and Blood-Clotting Tied to Hazards of Intermittent HIV Treatment (October 21, 2008)
From U.S. National Institutes of Health
- Interleukin-2 Ineffective in Maintaining Baseline CD4+ Cell Count During Treatment Interruption (February 6, 2008)
From The Body PRO
- Resuming Treatment Partly Restores Health of Patients in SMART Study (February 3, 2008)
In 15th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Are Previous Treatment Interruptions Associated With Higher Viral Rebound Rates in Patients With Viral Suppression? (January 30, 2008)
In AIDS
- Dutch Study Finds STIs Safe for Some (October 2007)
To read PDF, click here
In Project Inform Perspective, from Project Inform
- TILT: A Look at the Role of Interleukin-2 in Treatment Interruption Leans Toward the Negative (February 28, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- CD4+ Count-Guided Interruption of Antiretroviral Treatment (November 30, 2006)
In New England Journal of Medicine
- SMART & Staccato: Two CD4-Guided Treatment Interruption Trials With Contradictory Results (August 17, 2006)
In XVI International AIDS Conference
- Staccato Study Suggests That Some CD4-Guided Treatment Interruptions Can be Safe (August 8, 2006)
In Time
- Treatment Interruptions: SMART or Stupid? (Spring 2006)
An in-depth look at the data behind the SMART study -- and what lessons, if any, can be learned from the results.
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
- Intermittent Treatment-Interruption Arm of Major African Study Is Halted (March 15, 2006)
From aidsmap.com
- Community Sign-On Letter: Continue the SMART Trial (January 27, 2006)
From The Center for AIDS
- International HIV/AIDS Trial Finds Continuous Antiretroviral Therapy Superior to Episodic Therapy (January 18, 2006)
The massive, international SMART trial is abruptly cancelled due to a twofold greater risk of progression to AIDS among people taking periodic treatment interruptions.
To read PDF, click here
From U.S. National Institute of Allergy and Infectious Diseases
- Treatment Action Group Statement on the Termination of the SMART Study (January 18, 2006)
Many other types of HIV treatment interruptions may still have a benefit -- it is still too early to call them a failed strategy, the group says.
To read PDF, click here
From Treatment Action Group
- Virologic Suppression Between Six and 18 Months on New Regimen Can Predict Long-Term Outcomes (December 16, 2005)
[Archived Article]
In addition, patients who previously had a treatment interruption appear less likely to succeed on their current regimen.
In The 45th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Case Report: Four-Year Treatment Break Reverses Woman's Lipohypertrophy, but Not Lipoatrophy (October 11, 2005)
[Archived Article]
From aidsmap.com
- Efavirenz Clearance May Take Up to 8 Weeks, Case Report Warns; Implications for Treatment Interruption (September 28, 2005)
[Archived Article]
From aidsmap.com
- Treatment Interruption Less Successful When Nadir CD4 Count Is Below 200, Study Finds; Incomplete Post-Interruption Immune Recovery Is Concern (September 2005)
[Archived Article]
In AIDS Patient Care and STDs
- NNRTIs Have a Greater Risk of Resistance Than PIs When Used in Regimens After Treatment Break (August 26, 2005)
[Archived Article]
From aidsmap.com
- Lamivudine Monotherapy Better Than Treatment Interruption in Rescue Patients With M184V (July 27, 2005)
[Archived Article]
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment
- Giraffes and HIV: Treatment Interruptions With a Twist (March/April 2005)
[Archived Article]
Dr. Andrew Zalski explains the theory behind partial treatment interruptions -- stopping all but one carefully selected drug in a person's HAART regimen.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Comparing a Treatment Interruption With or Without Interleukin-2 in Delaying a Falling CD4+ Cell Count (February 25, 2005)
[Archived Article]
In The 12th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Supervised Treatment Interruptions After Successful HAART: Strategy Usually Not Successful Over Long Term (December 31, 2004)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Weekend Treatment Interruptions for Certain Well-Controlled Patients: Interview With Cal Cohen, M.D. (December 31, 2004)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- HIV JournalView: When to Stop Antiretroviral Therapy? (December 2004)
[Archived Article]
A JAIDS study finds that treatment discontinuation is safe in some patients with CD4+ cell counts over 250.
From The Body PRO
- Treatment Interruption May Work for People With Pre-HAART CD4 Counts Over 250 (October 26, 2004)
[Archived Article]
From aidsmap.com
- CD4-Guided Pulse Therapy; Induction/Maintenance Therapy: Research From AIDS 2004 (September 2004)
[Archived Article]
A list of studies examining these two therapy-sparing approaches to HIV treatment.
In TAGline, from Treatment Action Group
- French Researchers Question Benefit of Lifelong Antiretroviral Treatment (August 2004)
[Archived Article]
A small, limited study suggests that after three years of use, HAART may reach the apex of its immunologic benefit.
In TAGline, from Treatment Action Group
- Five Days On, 2 Days Off: A Pilot Study on Innovative Treatment of HIV Infection (July 13, 2004)
[Archived Article]
In The XV International AIDS Conference, from The Body PRO
- Weekly Cycles of Once-Daily Anti-HIV Drugs Could Reduce Cost of HIV Treatment (May 20, 2004)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Benefit of Treatment Interruption in HIV-Infected Patients With Multiple Therapeutic Failures: A Randomized Controlled Trial (March 12, 2004)
[Archived Article]
Contrary to earlier findings, this study suggests interruptions can be successful in multi-drug-resistant patients.
From Johns Hopkins AIDS Service
- Structured Treatment Interruption Part I: Overview (February 11, 2004)
[Archived Article]
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Structured Treatment Interruption Part II: Case Studies (February 11, 2004)
[Archived Article]
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Interruption of Treatment Is Safe for Those Who Started Too Early (December 2003/January 2004)
[Archived Article]
A recent European study bolsters the idea that HIV-positive people who started treatment with CD4 counts over 350 can safely stop.
From HIV i-Base
- Failures of One Week On, One Week Off Antiretroviral Therapies in a Randomized Trial (November 2003)
[Archived Article]
Abstract of a study in the journal AIDS.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- CD4-Guided Treatment Interruptions: A New Therapeutic Strategy (September 15, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
- Negative Impact of Drug Holidays in HIV-Infected Patients on NNRTIs (September 15, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
- Structured Treatment Interruptions Successful With Patients Who Have High CD4 Counts (September 14, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
- Treatment Interruption: Study Found Poor Result for Highly Treated, Highly Resistant Patients (September 12, 2003)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Treatment Interruption Shows No Benefit in Drug-Resistant HIV Infection (August 27, 2003)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Intermittent HIV Therapy Still Not a Viable Option (July 16, 2003)
[Archived Article]
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- Structured Treatment Interruption Failure in Treatment-Experienced Patients (July 15, 2003)
[Archived Article]
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- An Interview With Dr. Cal Cohen on Highlights From the 10th Conference on Retroviruses and Opportunistic Infections (April 4, 2003)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Structured Treatment Interruption (STI) (March 3, 2003)
[Archived Article]
Part of HIV InSite's coverage of the 10th Conference on Retroviruses and Opportunistic Infections.
From HIV InSite
- Key Therapeutic Decisions in Managing HIV Infection (Spring 2003)
[Archived Article]
An update on when to start, when to switch and when to stop, from STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project
- Structured Treatment Interruption as a Long-Term Treatment Strategy (Spring 2003)
[Archived Article]
From STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project
- Structured Treatment Interruption to Increase Response to Salvage Therapy (Spring 2003)
[Archived Article]
From STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project
- Benefit of Interrupting AIDS Drugs Is Debated; New Research Supports Both Sides (February 13, 2003)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Swiss-Spanish Intermittent Treatment Trial: A Qualified Failure? (January 29, 2003)
[Archived Article]
The results from the largest structured treatment interruption trial to date may not be as terrible as advertised.
In TAGline, from Treatment Action Group
- Salvage Strategies and STI at the 10th Annual Retrovirus Conference (January/February 2003)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Research From the 42nd ICAAC: Predicting Rebounds, Predicting Death (December 2002)
[Archived Article]
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- Predictors of Long-Term Response to Therapy Resumption After Treatment Interruption in HIV-1 Infected Patients Failing Antiretroviral Therapy (November 19, 2002)
[Archived Article]
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
- Shift in HIV-1 Resistance After Treatment Interruption in Patients With Virological Failure and Antiviral Effect Following Trizivir Plus Efavirenz (AZLF3003 Study) (November 19, 2002)
[Archived Article]
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
- Treatment Interruptions (November 18, 2002)
[Archived Article]
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
- Antiviral Therapy 2002 (November 17, 2002)
[Archived Article]
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO
- Altered States (November 2002)
[Archived Article]
An overview of results from the 2002 Swiss-Spanish Intermittent Treatment Trial.
In TAGline, from Treatment Action Group
- Supervised Treatment Interruption in an Urban HIV Clinical Practice: A Prospective Analysis (October 26, 2002)
[Archived Article]
In 40th Annual Meeting of the Infectious Diseases Society of America, from The Body PRO
- Key T-Cell Subset Loses Efficacy During Structured Treatment Interruptions (October 11, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- "Drug Holidays" Not Beneficial for Fighting HIV (September 25, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- HAART Interruption Strategies: How, When, and Why? (September 2002)
[Archived Article]
A review of the latest research.
In The PRN Notebook
- STIs in Chronic Infection: Predicting Success (September 2002)
[Archived Article]
In TAGline, from Treatment Action Group
- Long-Term Interruption of HIV Treatment May Be Safe in Certain Patients (August 29, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Digging Deeper at the Resistance Workshop (August 14, 2002)
[Archived Article]
Key clinical findings from July's XI International HIV Drug Resistance Workshop.
From International AIDS Society
- Drug Halt Can Reduce Resistance in Late-Stage AIDS (July 11, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Dynamics of Viral Rebound in Plasma and Semen After Stopping Effective Antiretroviral Therapy (July 11, 2002)
[Archived Article]
In The XIV International AIDS Conference, from The Body PRO
- Strategies to Prevent Loss of CD4+ and Onset of Resistance During Treatment Interruptions (July 11, 2002)
[Archived Article]
In The XIV International AIDS Conference, from The Body PRO
- Treatment Interruptions: A Summary of the Data to Date (July 11, 2002)
[Archived Article]
In The XIV International AIDS Conference, from The Body PRO
- Special Retrovirus Update: Structured Treatment Interruptions (March 28, 2002)
[Archived Article]
To read PDF, click here
In STEP Ezine, from Seattle Treatment Education Project
- 9th Retrovirus Conference Coverage: Structured Treatment Interruptions (Spring 2002)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
- Anti-HIV Therapy Update: STI and Third-Line Therapy (March 2002)
[Archived Article]
In Project Inform Perspective, from Project Inform
- Strategic Treatment Interruptions: Where Are We? (February 26, 2002)
[Archived Article]
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- SSITT: A Prospective Trial of Treatment Interruptions in HIV Infection (February 25, 2002)
[Archived Article]
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- HAART Therapy: One Week On, One Week Off? (January 2002)
[Archived Article]
In HEPP News, from Brown Medical School
- Whatever Happened to Structured Treatment Interruptions? (Winter 2001/2002)
[Archived Article]
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
- Structured Treatment Interruptions for the Management of HIV Infection (December 19, 2001)
[Archived Article]
In Journal of the American Medical Association
- Long-Term Effects of Treatment Interruptions: 18-Month Evaluation of a Controlled Trial in >300 HIV-Positive Patients (December 18, 2001)
[Archived Article]
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO
- Predictors of Virologic and Immunologic Success Post Treatment Interruption (TI) in Patients with Chronic HIV Infection (December 18, 2001)
[Archived Article]
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO
- Structured Treatment Interruptions (STI) in Patients Receiving HAART Since Primary HIV-1 Infection (PHI): Spontaneous Control of Viremia in Almost Half of Cases After the First Two Cycles Off Therapy (December 18, 2001)
[Archived Article]
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO
- STI in Patients with Incomplete Viral Suppression (December 16, 2001)
[Archived Article]
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO
- Use of Structured Treatment Interruptions in Primary Infections (December 16, 2001)
[Archived Article]
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO
- 7-Day-On, 7-Day-Off Regimen Could Reduce Cost, Toxicities of HIV Therapy (December 3, 2001)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Interrupting AIDS Treatment Shows Promise (November 2001)
[Archived Article]
In Body Positive, from Body Positive
- Therapy Interruptus (November 2001)
[Archived Article]
The latest news on medically monitored HIV treatment interruptions.
In Reasons for Hope, from Search for a Cure
- Structured Treatment Interruption: Panacea or Pandora? (October 27, 2001)
[Archived Article]
In 39th Annual Meeting of the Infectious Diseases Society of America, from The Body PRO
- Treatment Interruption: Erroneous Press Report (July 27, 2001)
[Archived Article]
To read PDF, click here
In AIDS Treatment News, from AIDS Treatment News
- Effects of Prolonged Discontinuation of Successful Antiretroviral Therapy (July 9, 2001)
[Archived Article]
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- CD4 Cell Response During Lengthy or Unsupervised Treatment Interruptions (Summer/Autumn 2001)
[Archived Article]
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
- Spanish Doctors Try Switching Therapy From Month to Month (May 16, 2001)
[Archived Article]
From Canadian AIDS Treatment Information Exchange
- SMART Study: Background, Concepts, and Design (Spring 2001)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
- Drug Holidays, Structured Treatment Interruptions, and Structured Intermittent Therapy (Februray 19, 2001)
[Archived Article]
In The 2001 National Conference on African Americans and AIDS, from The Body PRO
- Virologic and Immunologic Consequences of Discontinuing Combination Antiretroviral-Drug Therapy in HIV-Infected Patients With Detectable Viremia (February 15, 2001)
[Archived Article]
In New England Journal of Medicine
- New Insights Into Viral Reservoirs and HIV Treatment Interruptions (February 7, 2001)
[Archived Article]
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Structured Treatment Interruption: Novel Strategy or Oxymoron? (February 6, 2001)
[Archived Article]
Summaries of two notable studies presented during a symposium on STIs.
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- The Effect of Treatment Interruption in Patients With Virologic Failure: Results From a Multi-Cohort Collaborative Study (February 6, 2001)
[Archived Article]
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Two Studies Examine Value of Intermittent Treatment Interruptions (February 6, 2001)
[Archived Article]
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Structured Treatment Interruptions Workshop Summary (January 31, 2001)
[Archived Article]
To read PDF, click here
From Project Inform
- 2000: A Year of Endings and Beginnings (January/February 2001)
[Archived Article]
Developments in structured treatment interruptions, new treatments, clinical trial enrollment and treatment for Africa.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- The Buzz: Drug Holidays and Lipodystrophy: Ongoing Controversies and Research (January/February 2001)
[Archived Article]
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Structured Treatment Interruption: Important Controlled Trial in Monkeys (December 1, 2000)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Report on the First International Acute HIV Infection Conference (November 27, 2000)
[Archived Article]
In STEP Ezine, from Seattle Treatment Education Project
- Finding the Right Use for Treatment Interruptions: STI May Work for People Who Begin HAART During Primary HIV Infection (September 29, 2000)
[Archived Article]
In STEP Ezine, from Seattle Treatment Education Project
- Follow-up Data from Studies of Intermittent Therapy and Treatment Interruption (August 8, 2000)
[Archived Article]
In STEP Ezine, from Seattle Treatment Education Project
- Weekly Intermittent Treatment: Caution (July 28, 2000)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- New Developments in Affordable Antiretroviral Therapy: Several Studies Examine Intermittent Treatment (July 13, 2000)
[Archived Article]
In The XIII International AIDS Conference, from The Body PRO
- Fauci Presents New Data on Structured Intermittent Therapy at XIIIth World AIDS Conference in Durban, South Africa (July 11, 2000)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Evaluating Structured Treatment Interruptions: Rationale, Experience, Potential Risks, and Benefits (June 2000)
[Archived Article]
In The PRN Notebook
- Treatment Interruption: Experts Sound Cautious Note at San Francisco Forum; Meeting Proceeds Despite Disruption (April 21, 2000)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Bonanza: With Demand for Treatment Breaks at Record Level, Market for Tiny, Uninterpretable Studies Flourishes (April 2000)
[Archived Article]
In TAGline, from Treatment Action Group
- Cessation of HAART Plus Daily Low-Dose Interleukin 2 to Promote Immunity to HIV (January 31, 2000)
[Archived Article]
In The 7th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Control of Viremia After Treatment Interruption (January 31, 2000)
[Archived Article]
In The 7th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Increase in Breadth and Frequency of CTL Responses After Structured Therapy Interruptions in Individuals Treated With HAART During Acute HIV-1 Infection (January 31, 2000)
[Archived Article]
In The 7th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Trend in Treatment Interruptions Gains Popularity; Activists Call for Systematic Observation (January 2000)
[Archived Article]
In TAGline, from Treatment Action Group
- Treatment Interruption Research: The Trial Most Needed Now (June 4, 1999)
[Archived Article]
From AIDS Treatment News
- Intermittent HIV Therapy (Spring 1999)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
|
|
Advertisement
|
E-Mail
Glossary
Share
