Research on HIV/AIDS Drug Resistance
Overviews
- Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms (August 1, 2009)
In The Journal of Infectious Diseases
- Nucleoside RT Inhibitor Surveillance Drug Resistance Mutation (SDRM) List: 34 Mutations at 15 Positions (March 6, 2009)
In PLoS ONE
- Natural Variation of HIV-1 Group M Integrase: Implications for a New Class of Antiretroviral Inhibitors (August 7, 2008)
In Retrovirology
- News on HIV Drug Resistance in New Antiretrovirals From the XVI International HIV Drug Resistance Workshop (July 24, 2007)
With every new medication it's critical to understand which mutations are predictive of a less than optimal response. In this report on Doug Richman's review from the XVI International HIV Drug Resistance Workshop, Mark Holodniy, M.D., discusses genotypic and phenotypic assays associated with R5 inhibitors and HIV drug resistance associated with the following antiretrovirals in development: etravirine, raltegravir, elvitegravir and maraviroc.
In 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from The Body PRO
- New Developments in the Management of HIV Treatment-Naive Patients (February 28, 2007)
Includes an analysis of research examining once-daily regimens, the use of viral decay rate to assess treatment efficacy, and issues related to primary HIV drug resistance.
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Baseline NNRTI Resistance and Virologic Failure in Treatment-Naive Patients on Efavirenz: An Interview With Daniel Kuritzkes, M.D. (February 26, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Optimizing Therapy for Patients With Multidrug-Resistant HIV (July 31, 2006)
To read PDF, click here
From Insight Medical Communications Inc.
- Survey Reveals Nearly Twice as Many Physicians Than Patients Are Concerned About HIV Drug Resistance (July 18, 2006)
From American Academy of HIV Medicine
- New Developments in HIV Drug Resistance and Options for Treatment-Experienced Patients (May 15, 2006)
Coverage of the 4th European HIV Drug Resistance Workshop and the 12th Annual Conference of the British HIV Association
Free CME/CE credit available for physicians, nurses and pharmacists.
From The Body PRO
- Wall Street Journal Spotlights HIVers With Heavy Drug Resistance (May 3, 2006)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Conference Presentation Provides Overview of Some Drug Resistance Assays (July 25, 2005)
[Archived Article]
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment
- The Link Between Unsafe Sex, Poor HAART Adherence, Resistance and Drug Resistant HIV Transmission (July 25, 2005)
[Archived Article]
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment
- HIV Drug Resistance Notes: Resistance Levels Conferred by Key Mutations (December 2004)
[Archived Article]
A class-by-class chart of drug resistance associated with specific HIV gene mutations, adapted from the Stanford HIV Drug Resistance Database.
To read PDF, click here
In Infectious Diseases in Corrections Report, from Brown Medical School
- Overview of ICAAC 2004 Research on HIV Drug Resistance (November 2004)
[Archived Article]
Mark Mascolini on the transmission of drug-resistant HIV, the lack of a tie between resistance and viral load "blips," the existence of a tie between resistance and persistently detectable viral load, and the significance of the K65R mutation.
From National AIDS Treatment Advocacy Project
- Reduced Drug Susceptibility Found Among 23% of Treatment-Naive Patients (October 31, 2004)
[Archived Article]
Reduced susceptibility to the NNRTI class was found to be most common; phenotypic resistance was most likely among white patients.
From aidsmap.com
- New Insight Into HIV Drug Resistance (September 2004)
[Archived Article]
In this summarized talk, Daniel R. Kuritzkes, M.D., discusses the latest, most significant findings.
In The PRN Notebook
- Resistance Reshufflings: Highlights of the XIII International HIV Drug Resistance Workshop (August 2004)
[Archived Article]
Summaries of a wide range of data presented at Tenerife, Canary Islands, from June 8-12, 2004.
To read PDF, click here
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- Report from the XIII International Workshop on HIV Drug Resistance (June 2004)
[Archived Article]
By David Margolis, M.D.; this conference took place from June 8-12, 2004, in the Canary Islands.
From National AIDS Treatment Advocacy Project
- Update on the Treatment of Acute and Early HIV Infection (May 2004)
[Archived Article]
Details of a talk by Dr. Martin Markowitz of the Aaron Diamond AIDS Research Center and Dr. Bruce Walker of Harvard Medical School; includes a discussion of drug resistance transmission.
In The PRN Notebook
- 2nd European HIV Drug Resistance Workshop: Slide Presentations (March 11-13, 2004)
[Archived Article]
From HIVpresentation.com
- 2nd European HIV Drug Resistance Workshop: Study Abstracts (March 11-13, 2004)
[Archived Article]
From HIVpresentation.com
- Highlights of the 2nd European HIV Drug Resistance Workshop (PDF) (March 11-13, 2004)
[Archived Article]
In Virology Education
- Mechanisms of HIV Drug Resistance: A Primer (March 2004)
[Archived Article]
In The PRN Notebook
- Importance of Resistance Testing and Therapeutic Drug Monitoring for Treatment Success (September 16, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
- Managing Patients After Virologic Failure (September 15, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
- Transmission of Drug-Resistant HIV (September 2003)
[Archived Article]
A review of recent research on the spread of HIV drug resistance, and what impact it might have on HIV treatment in the future.
In The PRN Notebook
- Clinical Use of Drug Resistance Testing (July 14, 2003)
[Archived Article]
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- Questions to and Answers From the International AIDS Society-USA Resistance Testing Guidelines Panel (PDF) (July/August 2003)
[Archived Article]
Twenty questions about drug resistance addressed by top medical experts.
In Topics in HIV Medicine
- Is Transmitted Drug Resistance in HIV on the Rise? It Seems So (May 5, 2001)
[Archived Article]
In British Medical Journal
- Use of Genotypic Resistance Testing To Guide HIV Therapy: Clinical Impact and Cost-Effectiveness (March 20, 2001)
[Archived Article]
In The Annals of Internal Medicine
- HIV Drug Resistance and Drug-Resistance Testing (March 2001)
[Archived Article]
To read PDF, click here
In The PRN Notebook
- Journal Watch: Genotype Testing (July/August 1999)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- The Virus Fights Back (July 7, 1998)
[Archived Article]
At the World AIDS conference, hope mingles with troubling news about drug-resistant HIV.
In The Village Voice
Resistance Risk
- Researchers Develop Questions to Determine Risk of HIV/AIDS Drug Resistance (May 19, 2009)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Sudden Drop Observed in Transmitted HIV Drug Resistance Among Cohort of Recently Infected San Francisco Patients (February 10, 2009)
Vivek Jain, M.D., presents data from a cohort of 266 patients with acute and early HIV infection, among whom a sudden drop in the prevalence of transmitted HIV drug resistance occurred in 2008 -- dramatically reversing a general upward trend over the previous four years.
In The 16th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Regimens With Boosted Protease Inhibitors Are the Most Resistance-Proof, Study Finds (May 22, 2008)
In The Journal of Infectious Diseases
- Drug Use During Sex May Make Infection With Drug-Resistant HIV More Likely (May 20, 2008)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Consequences of Non-Adherence Worse in African-Americans than White People (December 16, 2007)
From aidsmap.com
- First-Line Triple-Combination Antiretroviral Therapy Provides Long-Term Protection Against AIDS-Related Illnesses, Study Says (December 10, 2007)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Drug-Resistant HIV Transmission Is Falling Steadily in United Kingdom (May 1, 2007)
From aidsmap.com
- Emergence of Drug Resistance and First-Line Combination Therapy in the Swiss HIV Cohort Study (February 26, 2007)
To view original study poster, click here (PDF).
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- HIV Drug Resistance Common Among Recently Infected MSM: An Interview With Susan H. Eshleman, M.D., Ph.D., Johns Hopkins University (February 26, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- More Than 10% of U.S. Patients in 11 U.S. States With Either Newly or Recently Acquired HIV May Harbor Resistant Virus (February 26, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- The Incidence of Multidrug-Resistant Virus Appears to Be Declining in the HAART Era (November 14, 2006)
In 8th International Congress on Drug Therapy in HIV Infection
- Higher Degree of Medication "Forgiveness" in Use of Boosted Protease Inhibitors (August 15, 2006)
In The XVI International AIDS Conference
- HIV JournalView: Adherence, Viral Fitness and NNRTI and PI Resistance (February/March 2006)
Bangsberg et al find that NNRTIs are more likely to suppress HIV than a single PI, but are also more vulnerable to resistance at low adherence levels.
From The Body PRO
- More Sensitive Drug-Resistance Tests Yield Higher Rates of Multidrug Resistance in Treatment-Naive Patients (February 8, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections
- Transmission of Multidrug-Resistant HIV Will Not Become More Frequent in United Kingdom Through 2010, Statistical Model Suggests (February 8, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections
- HIV JournalView: Low-Level Viremia May Slowly Breed Resistance, but Watch Out for NNRTIs (January 2006)
Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005.
In HIV JournalView, from The Body PRO
- Crystal Methamphetamine Use and Antiretroviral Drug Resistance: A Pilot Study of Behavioral and Clinical Correlates (October 2005)
[Archived Article]
To read PDF, click here
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- HIV JournalView: Persistent, Low-Level Viremia May Breed Resistance (September 2005)
[Archived Article]
Whether treatment should be switched in viremic patients depends on the regimen and the viral load level, a new study suggests.
From The Body PRO
- NNRTIs Have a Greater Risk of Resistance Than PIs When Used in Regimens After Treatment Break (August 26, 2005)
[Archived Article]
From aidsmap.com
Research on Drug Resistance: 1996-1998
- Highlights From the Resistance Workshop (August/September 1998)
[Archived Article]
A report from the 12th World AIDS Conference.
In TAGline, from Treatment Action Group
- Mechanisms of Antiretroviral Therapy Failure: Resistance (May 1, 1998)
[Archived Article]
In The 8th Clinical Care Options for HIV Symposium, from The Body PRO
- Emergence of HIV-1 Resistance in Seminal Plasma of Men on Antiretroviral Therapy (February 4, 1998)
[Archived Article]
In The 5th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- First Test for HIV Resistance to Nucleoside Analogs Is Available (December 1997)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
- Clinical Implications of Resistance to Antiretroviral Drugs (November 21, 1997)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Update From the June 1997 International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication (November 7, 1997)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Is Resistance Always a Bad Thing? (June 1997)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
- Viral Resistance (report from the XIth International AIDS Conference) (Summer 1996)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
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