Open Clinical Trials

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U.S. HIV/AIDS Trial Databases

AIDSinfo (Regularly Updated)
An extensive, searchable list of trials, provided by the U.S. Department of Health and Human Services.
Browse for Clinical Trials by Category (Regularly Updated)
Alternative/Complementary Medicine; HIV Acute/Early Infection; HIV and anal dysplasia; HIV and cervical dysplasia; HIV and HPV; HIV and Pregnancy; HIV Prevention (mother-child transmission, behavior, vaccines, etc.); HIV Resistance/Resistance Testing; HIV Treatment Experienced; HIV Treatment Interruption; HIV Treatment Naive (little or no prior treatment); HIV Vaccines; Lipodystrophy/Lipoatrophy; Neuropathy; Observational Trials; Pediatric HIV; Post Exposure to HIV; General Search.
Complementary Therapy Trials for People With HIV (Regularly Updated)
Trials throughout the U.S.

NIAID's Clinical Trials Recruitment Database (Regularly Updated)
Provides information on experimental-treatment and vaccine studies conducted or supported by the National Institute of Allergy and Infectious Diseases.
TrialScope (Regularly Updated)
HIV InSite's state-by-state database of organizations conducting HIV-related clinical research; database provides contact information, links to organizational Web sites, and the types of research each site conducts.
ACRIA TrialSearch
A national database of enrolling HIV/AIDS clinical trials. Searchable by treatment, condition, CD4 and viral load counts, age and location.
From AIDS Community Research Initiative of America

U.S. Non-HIV Trial Databases

CenterWatch Clinical Trials Listing Service (Regularly Updated)
A thorough listing of industry-sponsored enrolling trials (not HIV-specific), searchable or browseable by medical area.
Clinical Trials Supported by the National Eye Institute (Regularly Updated)
May be of interest to HIV-positive patients, particularly those with CMV retinitis or other vision-impairing conditions.
ClinicalTrials.gov (Regularly Updated)
Searchable (by keyword) database of all research studies (including those related to HIV/AIDS) being conducted/sponsored by the National Institutes of Health, other federal agencies or the pharmaceutical industry.
CRISP: Computer Retrieval of Information on Scientific Projects (Regularly Updated)
A searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions.
National Cancer Institute: Clinical Trial Search (Regularly Updated)
A searchable database of open and closed cancer-related trials throughout the world.

Specific U.S. Nationwide Studies

AIDS Clinical Trial Group Trials Open for Enrollment (Regularly Updated)
ESPRIT: Interleukin Study (Regularly Updated)
A large-scale, randomized, international study of the effectiveness of IL-2 in HIV-positive people with CD4+ counts over 300.
The Neurologic AIDS Research Consortium (Regularly Updated)
The U.S. Military HIV Research Program (Regularly Updated)
Women's Interagency HIV Study (Regularly Updated)
A large, long-running, ongoing investigation of the clinical, laboratory and psychosocial aspects of HIV infection in women.
The Setpoint Study (Study A5217) (May/June 2008)
A randomized study comparing immediate treatment vs. treatment as indicated in newly-infected HIV-positive patients.
In Positively Aware, from Test Positive Aware Network
Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients (April 15, 2008)
Novel nucleoside-sparing regimen designed to avoid risk of toxicity associated with nucleoside class of HIV drugs.
From Schering-Plough
New Kind of Antiretroviral, KP-1461, Clinical Trial Recruiting; Interview With Stephen Becker, M.D. (October 11, 2007)
In AIDS Treatment News, from AIDS Treatment News
Tibotec Therapeutics Announces Initiation of the Largest U.S. Clinical Study Examining HIV Treatment in Treatment-Experienced Adult Women (September 28, 2006)
GRACE trial to explore gender-related differences in response to Prezista-based HIV therapy.
From Tibotec Therapeutics
Multicenter AIDS Cohort Study (MACS) (March 2005)
One of the longest-running, more significant studies of HIV infection in men, MACS is looking to expand its range to include more participants, especially minorities

Kidney, Liver Transplant Study for People With HIV (February 28, 2005)
A study of liver and kidney transplants for persons with HIV, at 19 U.S. transplant centers, is open to new patients.
In AIDS Treatment News, from AIDS Treatment News
NIAID Begins Enrolling Volunteers for Novel HIV Vaccine Study (January 24, 2005)
A news release announcing the launch of this Phase II trial, called the Step Study; worldwide study locations and eligibility criteria are listed.
From U.S. National Institute of Allergy and Infectious Diseases
Open Clinical Trials for HIV/AIDS Treatments (Winter 2005/2006)
A selection of 19 notable studies now enrolling at various sites throughout the U.S.; focuses range from antiretrovirals in development to experimental HIV prevention methods.
To read PDF, click here
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
Clinical Trial Information: SMART Study (October 2004)
Includes enrollment contact information for people in the Houston area.
In HIV Treatment ALERTS!, from The Center for AIDS
National Disease Research Interchange -- HIV Program (2003)
A place where HIV-positive individuals can donate organs and tissue for research.
The SMART Way to Fight AIDS (January 10, 2002)
From U.S. National Institute of Allergy and Infectious Diseases
SMART Starts! (And Not a Moment Too Soon) (January 2002)
In GMHC Treatment Issues, from Gay Men's Health Crisis

Trial Databases (Outside U.S.)

metaRegister of Controlled Trials (Regularly Updated)
A massive, searchable, global database of ongoing, randomized, controlled trials (Free registration is required to search the database).
Australian Clinical Studies (Regularly Updated)
Clinical Trials Currently Underway in Canada (Regularly Updated)
A listing provided by the Canadian HIV Trials Network.
IAVI Database of Preventive AIDS Vaccines in Human Trials (Regularly Updated)
A searchable, global database provided by the International AIDS Vaccine Initiative.

Specific Trials (Outside U.S.)

EuroSIDA: Impact of Antiretrovirals on HIV-Positive Europeans (Regularly Updated)
A very large, prospective, observational cohort study spanning the European continent.
Initio: Starting Antiretroviral Treatment (Regularly Updated)
A 15-country trial aiming to determine which of several drug combinations provides the most successful results after at least three years.
SPARTAC Study (April 8, 2006)
Clinical trial underway in the United Kingdom examining whether short-term treatment in recently infected people can delay the start of long-term therapy.
From Medical Research Council Clinical Trials Unit
Cancer Researchers Seek Men for Long-Term HPV Study in Brazil; Mexico; Tampa, Fla. (February 1, 2005)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
NIAID Begins Enrolling Volunteers for Novel HIV Vaccine Study (January 24, 2005)
A news release announcing the launch of this Phase II trial, called the Step Study; worldwide study locations and eligibility criteria are listed.
From U.S. National Institute of Allergy and Infectious Diseases

Alternative/Complementary Medicine

U.S. Government-Sponsored Clinical Trials on Complementary/Alternative Treatments for HIV and Antiretroviral Side Effects (Regularly Updated)
From National Center for Complementary and Alternative Medicine

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