HIV Long-Term Nonprogressors and Elite Controllers: Research
- Experts Study Thriving HIV "Controllers" in Vaccine Search (October 22, 2009)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Wall Street Journal Examines Study of Medical Outliers to Fight Disease (October 20, 2009)
In Kaiser Daily Global Health Policy Report, from Henry J. Kaiser Family Foundation
- Zephyr Foundation Launches New Community Forum for "HIV Controllers" (August 1, 2009)
The forum was created to bring together members of this small, unique worldwide community so they can more easily share their thoughts, feelings and stories -- and learn about opportunities to participate in research that might one day lead to a cure for HIV.
From Zephyr Foundation
- Study Examines "Elite" Group of HIV-Positive People Who Appear "Protected" From Developing AIDS (July 7, 2009)
In Kaiser Daily U.S. HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Elite Control of HIV Infection: Implications for Vaccine Design (January 2009)
In Expert Opinion on Biological Therapy
- Heterogenous Neutralizing Antibody and Antibody-Dependent Cell Cytotoxicity Responses in HIV-1 Elite Controllers (May 15, 2009)
In AIDS
- The Role of Natural Killer Cells in a Cohort of Elite Suppressors: Low Frequency of the Protective KIR3DS1 Allele and Limited Inhibition of HIV-1 Replication in vitro (May 2009)
In Journal of Virology
- Mucosal Immune Responses to HIV-1 in Elite Controllers: A Potential Correlate of Immune Control (April 23, 2009)
In Blood
- A Method for Identification of HIV gp140 Binding Memory B Cells in Human Blood (April 15, 2009)
In Journal of Immunological Methods
- Broad Diversity of Neutralizaing Antibodies Isolated From Memory B Cells in HIV-Infected Individuals (April 2, 2009)
In Nature
- HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers (April 2009)
In Journal of Virology
- Antibodies Present in Long-Term HIV Survivors Could Contribute to Vaccine Development, Study Says (March 17, 2009)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- HLA-B57/B*5801 Human Immnodeficiency Virus Type 1 Elite Controllers Select for Rare gag Variants Associated With Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition (March 2009)
In Journal of Virology
- 5% or More of Perinatally HIV-Infected Adolescents May Be Long-Term Nonprogressors, U.S. Study Suggests (February 10, 2009)
In what may be the first study of its kind, Rohan Hazra, M.D., offers data suggesting that a significant proportion of HIV-infected U.S. adolescents, all of whom were infected with HIV at birth, were able to remain off antiretroviral therapy for at least six months without experiencing any noticeable degree of disease progression.
In The 16th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Will You Become a Long-Term HIV Nonprogressor? Prediction is Possible, Researchers Suggest (January 12, 2009)
From aidsmap.com
- Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naive HIV Controllers (January 2009)
In Journal of Virology
- Evidence for Persistent Low-Level Viremia in Individuals Who Control Human Immunodeficiency Virus in the Absence of Antiretroviral Therapy (January 2009)
In Journal of Virology
- HLA- Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying a gag-Protease From Elite Controllers of Human Immunodeficiency Virus Type 1 (January 2009)
In Journal of Virology
- Well-Armed Immune Cells Help Long-Term Non-Progressors Contain HIV (December 4, 2008)
From National Institute of Allergy and Infectious Diseases
- Telomerase Activity of HIV-1-Specific CD8+ T Cells: Constitutive Upregulation in Controllers and Selective Increase by Blockade of PD Ligand 1 in Progressors (November 1, 2008)
In Blood
- Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes (September 2008)
In Journal of Virology
- HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, But Such Responses Are Not Always Necessary for Long-Term Virus Control (June 2008)
In Journal of Virology
- Genetic and Immunologic Heterogeneity Among Persons Who Control HIV Infection in the Absence of Therapy (February 15, 2008)
In Journal of Infectious Diseases
- APOBEC3G/F Mutation Not Responsible for HIV Viremia Control in Most Elite HIV Suppressors (February 6, 2008)
From The Body PRO
- Elite Controllers May Experience Higher Immune Activation Levels Than Other HIV-Infected Patients, Spurring Concerns of CD4+ Decline (February 6, 2008)
From The Body PRO
- Relationship Between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals With Undetectable Plasma HIV RNA Levels in the Absence of Therapy (January 1, 2008)
In Journal of Infectious Diseases
- The Major Histocompatibility Complex Class II Alleles Mamu-DRB1*1003 and -DRB1*0306 Are Enriched in a Cohort of SIV-Infected Rhesus Macaque Elite Controllers (January 2008)
In Journal of Virology
- CCL3L1 and CCR5 Influence Cell-Mediated Immunity and Affect HIV-AIDS Pathogenesis Via Viral Entry-Independent Mechanisms (December 2007)
In Nature Immunology
- HIV Controllers: How Do They Tame the Virus? (December 2007)
In Trends in Immunology
- Preserved Central Memory and Activated Effector Memory CD4+ T-Cell Subsets in Human Immunodeficiency Virus Controllers: An ANRS EP36 Study (December 2007)
In Journal of Virology
- Elite HIV Controllers: Myth or Reality? (October-December 2007)
In AIDS Reviews
- Human Immunodeficiency Virus Type 1 Controllers But Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines (November 2007)
In Journal of Virology
- Upregulation of CTLA-4 by HIV-Specific CD4+ T Cells Correlates With Disease Progression and Defines a Reversible Immune Dysfunction (November 2007)
In Nature Immunology
- Researchers Discover "Switch" Responsible for Turning Off the Immune System's Response Against HIV (September 30, 2007)
Potential treatment target needs further investigation before clinical testing.
From Massachusetts General Hospital
- Elite Control of HIV Infection: Implications for Vaccines and Treatment (August-September 2007)
In Topics in HIV Medicine
- Human Immunodeficiency Virus Controllers: Mechanisms of Durable Virus Control in the Absence of Antiretroviral Therapy (September 2007)
In Immunity
- Innate Partnership of HLA-B and KIR3DL1 Subtypes Against HIV-1 (June 2007)
In Nature Genetics
- HIV Replication-Competent HIV Strains Infect HIV Controllers Despite Undetectable Viremia (ANRS EP36 Study) (May 11, 2007)
In AIDS
- HIV Controllers Exhibit Potent CD8 T Cell Capacity to Suppress HIV Infection ex vivo and Peculiar Cytotoxic T Lymphocyte Activation Phenotype (April 17, 2007)
In Proceedings of the National Academy of Sciences
- Control of Human Immunodeficiency Virus Type 1 Is Associated With HLA-B*13 and Targeting of Multiple gag-Specific CD8+ T-Cell Epitopes (April 2007)
In Journal of Virology
- Subdominant CD8+ T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication (April 2007)
In Journal of Virology
- Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled Than in Progressive HIV-1 Infectio (March 28, 2007)
In PLoS ONE
- HIV Controllers: A Homogeneous Group of HIV-1 Infected Patients With a Spontaneous Control of Viral Replication (December 2006)
In Pathologie-biologie
- Who Are the Elite Controllers? (December 2005)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Phenotypic, Functional, and Kinetic Parameters Associated With Apparent T-Cell Control of Human Immunodeficiency Virus Replication in Individuals With and Without Antiretroviral Treatment (November 2005)
In Journal of Virology
- Researchers Examine What Makes Some Patients HIV Nonprogressors (September 7, 2005)
A new French study is unable to provide any hard-and-fast answers, but does shed some new light on the subject.
From aidsmap.com
- In Retraction, Researchers Say CD8 Antiviral Factor Not Attributable to Alpha-Defensins (January 23, 2004)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Scientist Admits Error in Study on HIV Survival (January 23, 2004)
Details of Dr. David Ho's retraction of a major finding regarding long-term HIV nonprogressors.
In San Francisco Chronicle
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