Research on Lipodystrophy & Other Metabolic Complications
Overview
- Surprising Changes in Body Fat With Darunavir Monotherapy (March/April 2010)
To read PDF, click here.
In Treatment Update, from Canadian AIDS Treatment Information Exchange
On TheBodyPRO.com
- ACTG 5202 Substudy Finds Little Lipoatrophy but Signs of Bone Loss Across the Board; Devil Is in the Details (February 19, 2010)
A discussion with Grace McComsey, M.D.
In The 17th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
- Can Carnitine Reduce Diabetes Risk and Improve Body Shape? (September 28, 2009)
From Canadian AIDS Treatment Information Exchange
On TheBodyPRO.com
- Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome? (April 2009)
Christos Mantzoros, M.D., an associate professor at Harvard Medical School, offers his take on whether there's a future for leptin replacement as a treatment for metabolic complications in people with HIV. (Editorial originally published in the Journal of Clinical Endocrinology & Metabolism.)
From National AIDS Treatment Advocacy Project
- Leptin Injections May Help HIVers With Lipoatrophy, Other Metabolic Problems, According to Small Study (April 2009)
The full text of a study published in the Journal of Clinical Endocrinology & Metabolism.
From National AIDS Treatment Advocacy Project
- HIV/HCV-Coinfected Patients Appear More Likely Than HIV-Monoinfected Patients to Develop Insulin Resistance After Initiating HAART (February 5, 2008)
From TheBodyPRO.com
- Body Fat Changes Becoming Less Common as HIVers Use Fat-Friendlier Meds, Study Finds (January 23, 2008)
In HIV Medicine
- Hepatitis C Coinfection Doesn't Increase the Risk of Lipoatrophy (May 21, 2007)
A pair of new U.S. studies appears to contradict long-held concerns that HIV/hepatitis C-coinfected people have a higher risk of diabetes and lipoatrophy (fat loss).
From aidsmap.com
- Increased Fat Consumption Observed in People With HIV With High Cholesterol (August 22, 2007)
From aidsmap.com
- Dietary Intervention When Starting HAART Prevents the Increase in Lipids Independently of Drug Regimen: A Randomized Trial (July 25, 2007)
From International AIDS Society
- The Role of Nucleoside Analogs in the Development of Insulin Resistance (July 24, 2007)
NRTIs to date have been thought to contribute to insulin resistance mainly via induction of lipoatrophy. The authors of this paper put forth another potential mechanism based on their findings: that is, zidovudine (AZT, Retrovir)-mediated mitochondrial toxicity in skeletal muscle, adipocytes and hepatocytes. Margaret Hoffman-Terry, M.D., reports.
In 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from TheBodyPRO.com
- Testosterone Levels, Fat Free Mass, Increases Differ According to HIV Drugs Taken (June 4, 2007)
From aidsmap.com
- Metabolic Complications: A CROI Round-Up (February 28, 2007)
Includes an analysis of research examining lopinavir/ritonavir vs. efavirenz, the use of growth hormone releasing factor to treat fat gain, the link between cardiovascular disease and HIV treatment, the use of ezetimibe (a choleserol-reducing agent) and the latest on bone health in HIV-infected patients.
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
- Metabolic Syndrome as Common in HIV-Negative as in HIV-Positive Individuals (February 15, 2007)
From aidsmap.com
- My Big Fat Metabolic Study: ACTG A5005s (February 2007)
DEXA outcomes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz or both plus dual nucleosides: long-term results from A5005s, a substudy of ACTG 384.
In HIV JournalView, from TheBodyPRO.com
- Metabolic Complications of HIV Therapy (September 2006)
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
On TheBodyPRO.com
- Metabolic Complications at the XVI International AIDS Conference: Part 2 -- Lipids (August 17, 2006)
In XVI International AIDS Conference
On TheBodyPRO.com
- Initiation of HAART May Increase Free Testosterone Levels and Fat-Free Mass (August 17, 2006)
In XVI International AIDS Conference
On TheBodyPRO.com
- Metabolic Complications at the XVI International AIDS Conference: Part 1 -- An Overview of New Data (August 17, 2006)
In XVI International AIDS Conference
On TheBodyPRO.com
- Body Fat Changes in People With HIV (August 14, 2006)
An interview with Todd Brown, M.D., Johns Hopkins School of Medicine.
In The XVI International AIDS Conference
On TheBodyPRO.com
- Research in Anti-Lipo Therapy Headlines AIDS Confab (February 8, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
- PI-Based Therapy Does Not Increase Glucose Intolerance, Gestational Diabetes in Pregnant, HIV-Infected Women (February 6, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections
On TheBodyPRO.com
- HIV JournalView: Metabolic Complications and HAART: Some New Answers and Many More Questions (January 2006)
Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005.
In HIV JournalView, from TheBodyPRO.com
- Benefit of Rosiglitazone or Metformin for Lipodystrophy Still Unclear (December 16, 2005)
In The 45th Interscience Conference on Antimicrobial Agents and Chemotherapy
On TheBodyPRO.com
- Drugs to Reverse Lipoatrophy Show So-So Effects (December 16, 2005)
In The 45th Interscience Conference on Antimicrobial Agents and Chemotherapy
On TheBodyPRO.com
- Protease Inhibitors Not Associated With Fat Gain; Some Antiretrovirals Can Cause Fat Loss, Study Says (November 3, 2005)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
On TheBodyPRO.com
- Moderate Weight Loss Increasingly Common for HIVers on HAART (September 1, 2005)
Wasting syndrome may be on the decline, but moderate weight loss -- of 5% or more -- has increased steadily since 1995, and appears unrelated to lipodystrophy.
From aidsmap.com
- HIV JournalView: Study Ties Insulin Resistance to NRTIs, Not PIs (September 2005)
d4T and 3TC are associated with insulin resistance and high insulin levels; indinavir is associated only with elevated insulin levels; and no link to insulin abnormalities is found for AZT or ddI.
From TheBodyPRO.com
- Abacavir Is Not Associated With the Metabolic Changes Seen in Patients Treated With Stavudine (February 24, 2005)
In The 12th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
- Five Ways to Tackle Toxicity (or the Ant, the Spider, and the Bee): 6th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV (January 2005)
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
On TheBodyPRO.com
- Fiber May Help Prevent Lipodystrophy (September 20, 2004)
Weight-bearing exercise and less smoking is also found to reduce the chances that men with HIV will develop fat around their waists.
To read PDF, click here.
From PositiveWords
- HIV JournalView: Exogenous Growth Hormone, an Expensive (and Questionable) Fat Accumulation Treatment (September 2004)
From TheBodyPRO.com
- HIV JournalView: Using Suction-Assisted Lipectomy to Treat Buffalo Hump (September 2004)
From TheBodyPRO.com
- Metabolic Complications of HIV and Its Therapies (July 16, 2004)
A detailed overview of recent research.
In The XV International AIDS Conference
On TheBodyPRO.com
- A HAART Regimen With Lower Metabolic Effect: Nevirapine Plus Non-Thymidine Analog NRTIs (July 14, 2004)
In The XV International AIDS Conference, from TheBodyPRO.com
- Kidney Fat Could Be a Predictor of Lipodystrophy (July 6, 2004)
Researchers use ultrasound to gauge the likelihood a patient will develop lipodystrophy after starting HAART, or whether a treatment switch will improve existing lipodystrophy.
From aidsmap.com
- Vitamins and Exercise May Help HIV-Related Metabolic Disorders (June 19, 2004)
In The Advocate
- Vitamins, Exercise May Help Metabolic Disorders (June 16, 2004)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Lipid-Lowering Drug Helps Triglyceride Levels in HIVers With Lipodystrophy (June 2004)
A daily dose of fenofibrate is found to lower abnormally high triglyceride levels in HIV-positive people with lipodystrophy, without causing any severe side effects.
In American Journal of Medical Science
- Rosiglitazone Reduces Lipoatrophy, Hyperinsulinemia in HIV-Infected Patients, Study Finds (May 19, 2004)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
On TheBodyPRO.com
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- Fiber-, Protein-, Calorie-Rich Diet Appears to Protect Against Central Fat Gain in Men (December 11, 2003)
From aidsmap.com
- High-Fiber Diet in HIV-Positive Men Is Associated With Lower Risk of Developing Fat Deposition (November 2003)
Abstract of a study in the American Journal of Clinical Nutrition.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- New Form of Liposuction Able to Reduce Buffalo Hump -- At Least in the Short Term (October 20, 2003)
A combination of liposuction and ultrasound is found to make buffalo humps smaller, but for half of the study patients the hump eventually grew back fully.
From aidsmap.com
- Risk Factors for Buffalo Hump (October 2003)
From the 2nd International AIDS Society Conference.
In HIV Treatment ALERTS!, from The Center for AIDS
- A Better Way to Measure Lipodystrophy (October 2003)
In HIV Treatment ALERTS!, from The Center for AIDS
- Sublime Versus Simple Side Effect Stories (or, Forget the Adiponectin, Just Stop Smoking) -- 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV (October 2003)
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
On TheBodyPRO.com
- Dyslipidemia: Change to Tenofovir? (September 15, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from TheBodyPRO.com
- Women Get More Lipodystrophy Than Men, Says Italian Study (September 10, 2003)
In this large study, women on HAART were found to be at a greater risk for developing body fat changes than men -- although men generally seemed to LOSE fat more often than women.
From aidsmap.com
- FRAM Study: The Skinny on Lipodystrophy (September 2003)
2nd International AIDS Society Conference on HIV Pathogenesis and Treatment.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- Antioxidants Have Little Benefit in People With Lipoatrophy (August 29, 2003)
A combination of vitamin E, vitamin C and N-acetylcysteine has positive and negative health results.
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
On TheBodyPRO.com
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- Research From the 42nd ICAAC: High Lopinavir Levels Predict High Lipids (December 2002)
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- Cost-Effectiveness Implications of the Timing of Antiretroviral Therapy in HIV-Infected Adults (November 25, 2002)
A study asserts that, generally speaking, the risks of lipodystrophy and heart disease are outweighed by the benefits of early HIV treatment.
In Archives of Internal Medicine
- National Institutes of Health Awards $1.95 Million to Study New Treatments for Drug Side Effects (November 22, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
On TheBodyPRO.com
- Metabolic Toxicities and HIV (November/December 2002)
To read PDF, click here.
In Positively Aware, from Test Positive Aware Network
- Study Finds Protease Inhibitors May Help Cause Lipodystrophy (October 30, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
On TheBodyPRO.com
- Evaluation of Coronary Artery Calcification by Electron Beam Computed Tomography in HIV-Infected Men Receiving Prolonged Protease Inhibitor Therapy (October 26, 2002)
In 40th Annual Meeting of the Infectious Diseases Society of America, from TheBodyPRO.com
- Study Reports Self-Image Concerns in HIV-Positive People With Lipodystrophy (October 22, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
On TheBodyPRO.com
- Insulin Resistance and HIV-Related Lipoatrophy (October 9, 2002)
Dr. Nasser Mikhail attempts to explain recent study findings.
In Journal of the American Medical Association
- HIV Positive May Risk Death to Avoid Side Effect of Meds (October 2, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
On TheBodyPRO.com
- The Case Against Zerit (October 2002)
Research increasingly points to NRTIs -- particularly d4T -- as a likely culprit in metabolic disorders.
In GMHC Treatment Issues, from Gay Men's Health Crisis
On TheBodyPRO.com
VIEW ALL ARTICLES
- Metabolic Complications of HIV Disease (December 18, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from TheBodyPRO.com
- Select HIV Protease Inhibitors Alter Bone and Fat Metabolism In Vitro (December 16, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from TheBodyPRO.com
- Triglyceride Increase Can Predict Lipodystrophy in HIV Patients Under HAART (December 16, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from TheBodyPRO.com
- Rise in HDL Cholesterol Associated With Nevirapine Containing Antiretroviral Therapy in HIV-1 Infected Patients Is Sustained Over 48 Weeks of Treatment (October 29, 2001)
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from TheBodyPRO.com
- Associations Between Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Use and HIV-Associated Lipodystrophy Syndrome (HALS) in the Dagna-LipART Cohort Study (October 29, 2001)
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from TheBodyPRO.com
- Switching From PI-Based to NNRTI-Based Regimens: Clinical and Metabolic Outcomes (October 28, 2001)
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from TheBodyPRO.com
- The Impact of First Line Therapies on Lipid Metabolism: The FRAMS Data (October 28, 2001)
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from TheBodyPRO.com
- HIV-Positive Individuals and Fat Redistribution: Diet Modification May Be the Key (October 1, 2001)
To read PDF, click here.
In STEP Ezine, from Seattle Treatment Education Project
On TheBodyPRO.com
- Andractim for HAART-Associated Breast Enlargement (September 24, 2001)
From Canadian AIDS Treatment Information Exchange
- Role of Diet in Lipodystrophy (September 5, 2001)
This report is from the Steven Grinspoon Group at Harvard.
From The National AIDS Education and Training Centers
VIEW ALL ARTICLES
- Report on the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy (Winter 2000)
In STEP Perspective, from Seattle Treatment Education Project
- Update on Complications of HAART from ICAAC and the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV (November 2000)
In Hopkins HIV Report
- Extensive Coverage of the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy (ADRL 2000) (September 13-15, 2000)
By The Body's expert, Dr. Pablo Tebas.
In The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy, from TheBodyPRO.com
- Morphologic and Metabolic Changes Associated with HIV Therapy (September 2000)
In Hopkins HIV Report
- Metabolic and Body Shape Abnormalities (Autumn 2000)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
- Body Fat Changes: The Body Habitus in Durban (September/October 2000)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Lipid Disorders in HIV Infection (August 2000)
From International AIDS Society-USA
- "Switch" Studies for People with Lipodystrophy (August 2000)
In Project Inform Perspective, from Project Inform
- Metformin in the Treatment of HIV Lipodystrophy Syndrome: A Randomized Controlled Trial (July 26, 2000)
In Journal of the American Medical Association
- A Randomized Open-Label Comparative Trial of Dietary Advice With and Without Pravastatin for the Management of Protease Inhibitor (PI)-Associated Hypercholesterolemia (July 13, 2000)
In The XIII International AIDS Conference, from TheBodyPRO.com
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