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Entry Inhibitors in Development
- Fusion and Attachment Inhibitors (May 4, 2008)
To read PDF, click here
From AIDS InfoNet
- Incyte Halts Development of Promising New CCR5 Drug (April 10, 2008)
From Project Inform
- CCR5 Inhibitors in Development: New Data on SCH532706 and Vicriviroc (February 3, 2008)
In 15th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Schering-Plough Launches Phase III Trials of Experimental Antiretroviral Vicriviroc (September 19, 2007)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- CCR5 Entry Inhibitors: Vicriviroc (July 25, 2007)
Edwin DeJesus takes a look at recent data on vicriviroc, a CCR5 entry inhibitor currently being studied in treatment-experienced patients.
In 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from The Body PRO
- Tests on HIV Drug Bring Good Results (May 4, 2007)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- The Last Word on Aplaviroc: A CCR5 Antagonist With Poor Efficacy (December 19, 2006)
In 8th International Congress on Drug Therapy in HIV Infection
- No Difference in HAART Response in Patients With X4-Using HIV (September 29, 2006)
In 46th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Aplaviroc's Potency Against HIV Is Linked to Its Slow Dissociation From the CCR5 Receptor (August 17, 2006)
In XVI International AIDS Conference
- Co-Receptor Conundrum: The Challenges of Turning Theory Into Reality (April 2006)
At the moment, there are many more questions than answers about an investigational class of drugs known as co-receptor inhibitors.
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In TAGline, from Treatment Action Group
- Entry Inhibitors: The Ups and Downs of Drug Development (Spring 2006)
AIDS activist Lynda Dee offers her take on the successes and failures of this new class of drugs.
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In ACRIA Update, from AIDS Community Research Initiative of America
- Entry Inhibitors in Development (March 30, 2006)
An overview from Edwin DeJesus, M.D.
From The Body
- Biotech Firm Creates Genetically Modified Immune Cells That Resist HIV Infection in Vitro (December 20, 2005)
Sangamo aims to modify patients' immune cells to possess a CCR5 receptor mutation that may make them "uninfectable".
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- University of Arkansas Scientists Win $10.2 Million Grant to Block HIV Receptor (December 8, 2005)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Entry Inhibitors: A Race to the Finish Line (November 2005)
A discussion on the risks and benefits of CCR5 blockers, and a report on the status of maraviroc, vicriviroc and aplaviroc.
To read PDF, click here
In Project Inform Perspective, from Project Inform
- GlaxoSmithKline Stops All Clinical Trials of Entry Inhibitor Aplaviroc (October 25, 2005)
To read PDF, click here
From GlaxoSmithKline
- CCR5: A New Option for Those Who Have None Left (October 2005)
In Reasons for Hope, from Search for a Cure
- Liver Toxicity Halts Trials of CCR5 Antagonist Aplaviroc in Treatment-Naive Patients (September 19, 2005)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- 873140, a CCR5 Antagonist, Displays Activity Against R5-Tropic Virus in Naive and Experienced Patients (July 26, 2005)
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment
- Vicriviroc (SCH 417690, SCH-D), a CCR5 Antagonist, Generally Well Tolerated and Effective in 14-Day Monotherapy Study (July 26, 2005)
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment
- The Antiviral Benefits of 873140, a CCR5 Antagonist (February 24, 2005)
In The 12th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- A New Era in HIV Treatment -- The Entry Inhibitors (January/February 2005)
Daniel S. Berger, M.D., reviews the concept behind the CCR5 inhibitor, a new type of entry inhibitor in development.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Entry Inhibitors: Hope on the Horizon? (October 2004)
A quick look at 10 entry inhibitors in early stages of development.
To read PDF, click here
In HIV Treatment ALERTS!, from The Center for AIDS
- The X4 Files: CCR5 and CXCR4 Coreceptors (July/August 2004)
Several abstracts presented at AIDS 2004 examined these two sites on CD4 cells that may be targeted by a new class of antiretrovirals.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Entry Inhibitors in Development (July 2004)
Brief updates on PRO 542, SCH-D, UK-427,857 and GW-873140.
To read PDF, click here
In Project Inform Perspective, from Project Inform
- HIV Coreceptor Drugs on the Horizon (July/August 2004)
A summary of research on coreceptor inhibitors presented at AIDS 2004.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Drug Development News: CCR5 Blockers (May/June 2004)
Several are in clinical trials, but questions persist as to their usefulness in treatment-experienced patients.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- BMS 488043 (March/April 2004)
A review of the most recent studies regarding this attachment inhibitor in development that were presented at CROI 2004.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Receptor Blockers: GW873140, SCH-C, SCH-D (March/April 2004)
A quick look at data about these attachment inhibitors in development that was presented at CROI 2004.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- BMS-488043: New Mechanism to Stop HIV Entry (February 27, 2004)
In AIDS Treatment News, from AIDS Treatment News
- A Look at Antiretroviral Agents in Development -- An Attachment Inhibitor and Two CCR5 Receptor Antagonists (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- GW873140, a Promising CCR5 Inhibitor Candidate (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Waiting in the Wings: More New Drugs (November/December 2003)
A look at 908, TMC-125 and entry inhibitors in development.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Chinese Herb Blocks Chemokine Receptor, May Have Anti-HIV Effect (September 2003)
An abstract of a study on shikonin, a component of atraditional Chinese medicinal herb.
In Antimicrobial Agents and Chemotherapy
- Co-Receptor Overview: CC-CCR5 and CXCR4 (Fusin) (January 2003)
To read PDF, click here
From Project Inform
- New Anti-HIV Therapies: Other Fusion Inhibitors (January 2003)
To read PDF, click here
From Project Inform
- Anti-HIV Candidates in the Pipeline: Entry and Integrase Inhibitors (Winter 2002/2003)
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
- SCH-C Moves Ahead -- Carefully (September 2002)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- New Drugs: Attacking Chemokine Receptors (March 2002)
In Hopkins HIV Report
- New Targets Bring New Challenges (March 2002)
A closer look at integrase and entry inhibitors.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Identification and Characterization of a Novel Inhibitor of HIV-1 Entry (February 25, 2002)
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- The Next Target in Therapy: Viral Entry (July 10, 2001)
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- Development of CCR5 Antagonists as a New Class of Anti-HIV Therapeutic (February 7, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Entry and Integrase Inhibitors: The Next Class of Drugs (January 2001)
From AIDS Community Research Initiative of America
- A New Type of Anti-HIV Drugs: Fusion Inhibitors (Spring 2000)
In STEP Perspective, from Seattle Treatment Education Project
- Entry Inhibitors Are Featured at the 7th Conference on Retroviruses and Opportunistic Infections (Spring 2000)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
- Simply Medical -- A Look at Fusion Inhibitors (November 1999)
In Body Positive, from Body Positive
- Fusion and Fusion Inhibitors -- Understanding the News (Spring 1998)
In Women Alive Newsletter, from Women Alive
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