HIV/AIDS Clinical Trials

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A Guide to Clinical Trials: Interpreting Medical Research (Winter 2005/2006)
An overview of how clinical trials are constructed and how researchers make sense of study results.
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In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
A Guide to Clinical Trials: Understanding Clinical Studies (Summer 2005)
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In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation
Participating in a Clinical Trial (June 30, 2009)
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From AIDS InfoNet

The Basics

Information on Clinical Trials and Research (Regularly Updated)
From National Cancer Institute
How HIV Drugs Get Approved (August 9, 2009)
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From AIDS InfoNet
Understanding Clinical Trials (September 20, 2007)
From U.S. National Institutes of Health
Should I Join a Clinical Trial? (Winter 2006/2007)
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In ACRIA Update, from AIDS Community Research Initiative of America
Getting It Right: Being Smarter About Clinical Trials (June 2006)
In PLoS Medicine
Virtual Monotherapy: Can It Be Avoided in Clinical Trials? (Spring 2006)
If you have multidrug resistance, joining a clinical trial for a drug in development may carry risks as well as benefits.
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
Joining a Clinical Trial: Asking the Right Questions (January-March 2006)
In GMHC Treatment Issues, from Gay Men's Health Crisis
Let's Talk About It: Learning to Trust, Again (July/August 2004)
[Archived Article]
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
Who Are We Hurting: The Hesitation by People of Color (July/August 2004)
[Archived Article]
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
Clinical Trials: Making Them Work for You (January/February 2004)
In Survival News, from AIDS Survival Project
Should You Enroll in a Clinical Trial? (September/October 2002)
In Positive Living, from AIDS Project Los Angeles
Out of the Laboratory and Into the Bathroom Cabinet: Designing and Implementing Clinical Trials (Summer 2002)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
Independent Review of Research Data (February 2002)
[Archived Article]
The safeguards that work to ensure clinical trial results are complete and accurate.
In GMHC Treatment Issues, from Gay Men's Health Crisis
Clinical Studies (December 2001)
[Archived Article]
In WISE Words, from Project Inform
Rights and Responsibilities of Research Participants (December 2001)
[Archived Article]
In Body Positive, from Body Positive
A Long Road Traveled: Conflicts, Community and Clinical Trials (Summer 2001)
[Archived Article]
To read PDF, click here
In CRIA Update, from AIDS Community Research Initiative of America
FDA Discusses Trial Design for Salvage Therapy (April 2001)
[Archived Article]
In TAGline, from Treatment Action Group
Protecting Human Research Subjects (June 6, 2000)
[Archived Article]
From U.S. Department of Health and Human Services
Clinical Trials and Industry Influence: Major Report (June 2, 2000)
[Archived Article]
A study raises alarm about how pharmaceutical companies influence clinical trials in order to increase drug sales.
In AIDS Treatment News, from AIDS Treatment News
Long-Term Effectiveness Clinical Trials in HIV/AIDS (Spring 2000)
[Archived Article]
Improving the quality of survival. The community sends a consensus statement to the National Institutes of Health.
In GMHC Treatment Issues, from Gay Men's Health Crisis
A Comprehensive Look at Clinical Trials (2000)
From AIDS Community Research Initiative of America
Experimental Treatments: Unapproved but Not Always Unavailable (January/February 2000)
[Archived Article]
In FDA Consumer, from U.S. Food and Drug Administration
The Healing Power of Placebos (January/February 2000)
[Archived Article]
In FDA Consumer, from U.S. Food and Drug Administration
Clinical Trials vs. the Clinic (October 1999)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
The Nuts and Bolts of Clinical Trials (Fall 1999)
[Archived Article]
In Women Alive Newsletter, from Women Alive
Fact Sheet: AIDSTRIALS and AIDSDRUGS (April 1998)
[Archived Article]
How to search these databases for information on studies of experimental treatments.
From U.S. National Institutes of Health
FDA Publishes Conflict of Interest Rules for Clinical Trials (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Should You Participate in Clinical Trials? (December 1997)
In AIDS Care, from San Francisco General Hospital

Personal Accounts

Going to Extremes to Stay Alive (July/August 2004)
[Archived Article]
Most experts don't recommend joining a clinical trial just to get the latest experimental drugs, but that's exactly what Matt Sharp did -- and he has no regrets.
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In Positively Aware, from Test Positive Aware Network
My Kind of Life: I Was a Viread Guinea Pig (July/August 2004)
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In Positively Aware, from Test Positive Aware Network
How I Fell in Love With HIV Research (October 2001)
Sue Gibson reflects back on how she stumbled into the HIV-research field -- and on why people volunteer for research studies.
In GMHC Treatment Issues, from Gay Men's Health Crisis
Becoming a Member of the AIDS Clinical Trials Group (ACTG) Community Constituency Group (Summer 2000)
[Archived Article]
In Women Alive Newsletter, from Women Alive

News/General Articles

American Medical News Examines Clinical Trials Outsourcing (September 9, 2009)
In Kaiser Daily Global Health Policy Report, from Henry J. Kaiser Family Foundation
Prepping for a PrEP Trial (July/August 2009)
Why is it so hard to find young people to participate in HIV-related studies? While trying to find an assistant to help recruit young, gay men for a trial of pre-exposure HIV prophylaxis (PrEP), HIV advocate Keith Green may have stumbled on an answer: homophobia.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
After 25 Years, a Landmark HIV Study Is Still Going Strong (April 25, 2009)
The Multicenter AIDS Cohort Study (MACS) is one for the history books: It's one of the most important HIV/AIDS studies ever done, and over the past 25 years it has brought about many major discoveries.
From National Public Radio
ACRIA Trials In Progress (Fall 2008)
To read PDF, click here
In Achieve, from ACRIA and GMHC
Clinical Trials Units Selected for Newly Restructured HIV/AIDS Research Networks (March 14, 2007)
From U.S. National Institutes of Health
Moving Toward Assured Access to Treatment in Microbicide Trials (July 11, 2006)
In PLoS Medicine
Kaiser Daily HIV/AIDS Report Summarizes Opinion Pieces on NIH-Funded AIDS Drug Trials Involving Foster Children (May 24, 2005)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
Clinical Trials: Philadelphia Hospitals Combine to Form "Supersite" and Reduce Delays (September 15, 2004)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Smarter Clinical Trials for Faster Drug Development (August 23, 2004)
[Archived Article]
Experimental drugs are being tested in humans earlier in the development process, which can help speed the drugs' progress -- or their demise.
In AIDS Treatment News, from AIDS Treatment News
Conducting Clinical Trials Without Ethical Review (July 2004)
[Archived Article]
A recent series of unethical -- even illegal -- clinical trials in India is fueling concern over the "outsourcing" of studies to countries where study regulation is lax.
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In IAPAC Monthly, from International Association of Physicians in AIDS Care
Joining a Preventive HIV Vaccine Clinical Trial: Benefits and Risks (May 2004)
[Archived Article]
To read PDF, click here
In WISE Words, from Project Inform
Joining a Therapeutic HIV Vaccine Clinical Trial: Benefits and Risks (May 2004)
[Archived Article]
To read PDF, click here
In WISE Words, from Project Inform
Scramble for Africa (May/June 2004)
[Archived Article]
Gregg Gonsalves says a new kind of colonialism, not humanitarianism, is behind the U.S.'s new push for HIV treatment research in the developing world.
In GMHC Treatment Issues, from Gay Men's Health Crisis
CDC Offering $500,000 for Web-Based Studies of Men Who Have Sex With Men (July 21, 2003)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
Volunteers for New HIV Drugs Get Harder to Find (June 9, 2003)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
Africa: Problems Getting Antiretrovirals for Trials (May 30, 2003)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
New Guidance on Clinical Trial Design in Developing Treatment for HIV Infection (November 1, 2002)
[Archived Article]
From U.S. Food and Drug Administration
Florida: Wansiki Foundation's Fort Lauderdale Clinic Offers HIV-Treatment Trials (October 8, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
Improving Informed Consent: Insights From Behavioral Decision Research (October 2002)
[Archived Article]
An abstract from Medical Care.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
HIV Clinical Trials: Are They Still Needed? (Spring 2002)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
Major AIDS Studies to Increase Minority Enrollment, Answer New Questions (September 10, 2001)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
Death as an Endpoint (September 2001)
[Archived Article]
Killing PWAs for science, or providing information to prolong life?.
In GMHC Treatment Issues, from Gay Men's Health Crisis
Learning Basic Science From Clinical Trials (July 8, 2001)
[Archived Article]
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
Report From the Adult AIDS Clinical Trials Group (AACTG) Meeting (July/August 2001)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
It's Time for New Leadership at the AACTG (May 2001)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
In for the Long Haul: Debate Paves Way for Long-Term Trials (Spring 2001)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
SMART Study: Background, Concepts, and Design (Spring 2001)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
2000: A Year of Endings and Beginnings (January/February 2001)
[Archived Article]
Developments in structured treatment interruptions, new treatments, clinical trial enrollment and treatment for Africa.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
Clinical Trials and Industry Influence: Major Report (June 2, 2000)
[Archived Article]
A study raises alarm about how pharmaceutical companies influence clinical trials in order to increase drug sales.
In AIDS Treatment News, from AIDS Treatment News
AIDS Research Consortium of Atlanta Enrolls 50,000th Patient in National HIV/AIDS Study (March 2000)
[Archived Article]
In Survival News, from AIDS Survival Project
OCS Redux: International Statistical Panel Puts Observational Cohort Study Research Possibilities into Perspective, Identifies Limitations (March 2000)
[Archived Article]
In TAGline, from Treatment Action Group

Clinical Trials: 1997 - 1999

NIAID Renews Funding for the Adult AIDS Clinical Trials Group (December 22, 1999)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
New amfAR Treatment Directory Now Available (October 1, 1999)
[Archived Article]
From AIDS Treatment News
Strategy Trials: The Answer? (February 18, 1999)
[Archived Article]
From AIDS Treatment News
NIAID Opens First AIDS Vaccine Trial in Africa (February 8, 1999)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
Trials & Errors: Studies Look at Which Combinations Are Better (February 1999)
[Archived Article]
Clinical trials using NNRTIs with or instead of protease inhibitors.
From Seattle Treatment Education Project
Improving Drug Development: Exploratory Clinical Studies (January 8, 1999)
[Archived Article]
From AIDS Treatment News
ACTG Salvage Therapy Trials (January 1999)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Primary Infection Clinic Enrolling for NIH Studies (Winter 1998)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
Trials Now Enrolling (Fall 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
AIDS Diarrhea: Phase III Trial Recruiting in Over 30 U.S. Sites (July 17, 1998)
[Archived Article]
From AIDS Treatment News
Prospective Case Series in Clinical Trial Design -- Proposal, and NTZ Example (June 5, 1998)
[Archived Article]
From AIDS Treatment News
Trials Now Enrolling (Summer 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
Hepatitis C and HIV: Ribavirin Plus Interferon Study Recruiting (May 15, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
IL-2 Without Antiretroviral Therapy: Trial Near Washington, D.C. (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Oral Contraceptive / Nevirapine Interaction Trial (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Trials Now Enrolling (Spring 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
Selected Clinical Trials Open to Patients with HIV Disease (February 1998)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
Protease Inhibitor Failure Trial: Combination 1592, 141W94, and Efavirenz (December 5, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Fortovase Approved: New Saquinavir Formulation (November 21, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Pregnant Women Eligible for Single-Dose Nevirapine Study (October 3, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Adefovir Dipivoxil Trials: CD4 100-500, Protease Inhibitor Naive (September 5, 1997)
[Archived Article]
From AIDS Treatment News
DMP 266 Trials Recruiting, Many Cities -- Protease Inhibitor Naive (September 5, 1997)
[Archived Article]
From AIDS Treatment News
CMV Trials Struggle to Enroll (September 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Equality in Clinical Trials: Drugs and Gender (September 1997)
[Archived Article]
From U.S. Food and Drug Administration
IL-2 for HIV: The Long March Toward FDA Approval (September 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Major Pediatric Study Stopped Early: Combination Treatment Better (July 4, 1997)
[Archived Article]
From AIDS Treatment News
Saquinavir: Major Study Shows Survival Benefit in Treatment-Naive Patients (July 4, 1997)
[Archived Article]
From AIDS Treatment News
FDA Explores New Antiretroviral Trial Designs: Interview with David Feigal, M.D. (June 20, 1997)
[Archived Article]
From AIDS Treatment News
Clinical Trials and Viral Load: Statement for FDA Community Meeting May 16 (May 16, 1997)
[Archived Article]
From AIDS Treatment News
CMV Retinitis, Newly Diagnosed: RS-79070 Trial (May 1, 1997)
[Archived Article]
From AIDS Treatment News
CMV, RS-79070: Community Concern As Major Drug's Development Suspended (May 1, 1997)
[Archived Article]
From AIDS Treatment News
ACTG 268: Gradual vs. Routine Initiation of Prophylaxis (April 1997)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
Government Study Finds Protease Based Triple Combination Keeps Patients Alive Longer Than Double Nuke (April 1997)
[Archived Article]
From Treatment Action Group
Protease Inhibitors: Major Study Stopped When 3-Drug Arm Proves Superior (March 7, 1997)
[Archived Article]
From AIDS Treatment News
Data reviews halt three trials earlier than planned: ACTG 320, Merck Protocol 028 (March 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Study Confirms that Protease Inhibitor Cocktail Can Delay HIV Disease Progression and Death (March 1997)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
The Need for 'Strategy' Type Clinical Studies (March 1997)
[Archived Article]
From Treatment Action Group
Adefovir Dipivoxil: Broad-Spectrum Antiviral Trial, CD4 Count Under 100 (February 7, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Nelfinavir: Agouron Announces Expanded Access for Children, a Major New Trial, and Enlarged Expanded Access for Adults (January 17, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
AVANTI 1 Shows Immunological Benefit for Loviride (January 1997)
[Archived Article]
In The 4th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
Clinical Trials and Studies Seeking Patients (Winter 1996/1997)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
Commentary: Reinventing Expanded Access [sections on Nevirapine, Nelfinavir, 141W94, 1592U89, and Adefovir (January 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Final Results of CAESAR Study Demonstrate a Survival Benefit with 3TC (January 1997)
[Archived Article]
In The 4th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
Studies Find D4T Plus 3TC Effective Against HIV (January 24, 1997)
[Archived Article]
From amfAR, The Foundation for AIDS Research

Clinical Trials: 1996

Nevirapine Trial Confirms Dr. Schooley's Point (December 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
1592: Two Studies Recruiting (November 15, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Cytarabine Nixed for PML (November 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Nerve Growth Factor Study Opens (November 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Nelfinavir Expanded Access Program (October, 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Nelfinavir (Viracept™) Expanded Access Announced (September 19, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
CAESER Study Completed (September 1996)
[Archived Article]
In Hopkins HIV Report, from Johns Hopkins AIDS Service
1592 -- New Experimental Antiretroviral (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Five-Drug or Six-Drug Antiretroviral Therapy -- Conversation with Steven Scheibel, M.D. (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Nelfinavir Protease Inhibitor Study Recruiting (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Another Call for Strategy Trials (August 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
NAC: First Controlled Trial, Positive Results (July 5, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Protease Inhibitors: Ritonavir and Saquinavir Combination Trial Recruiting (April 19, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
California: Clinical Trials Computer Service Now Available Statewide (April 5, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Pediatric Treatment Update (March 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
ACTG Oncology Committee Finds New Home at National Cancer Institute, But Funding Is Woefully Inadequate (February 1996)
[Archived Article]
In TAGline, from Treatment Action Group
Curcumin Trial Finds No Activity (February 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Hydroxyurea Continues to Show Promise (February 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
New Anti-HIV Vaccine and KS Trials at the National Cancer Institute (February 1996)
[Archived Article]
By Robert Yarchoan, M.D., Chief, Retroviral Diseases Section, MB, DCS.
From National Cancer Institute
The First Integrase Inhibitor (January 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis

Clinical Trials: 1993

ACTG Clinical Trial Sites: Seven Cut, Two Added (December 22, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Peptide T: Negative Trial Result (November 3, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Viral Load: New "Strategy" Trial in 15 U.S. Cities (October 20, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Symptom-Reduction Trials at FDA Clinical Trials Workshop (September 29, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
"Confirmatory" Trials: Symptom Reduction As Efficacy Measure (August 18, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
Re-Inventing Government: New ACTG Structure Squeezes Eleven (February 1995)
[Archived Article]
Committees Into Three--But Will Anything Really Be Any Different?.
In TAGline, from Treatment Action Group
AIDS Clinical Trials Group Ready Themselves for 1996-2001 Funding (November 1994)
[Archived Article]
In TAGline, from Treatment Action Group
AIDS Clinical Trials Group Rescue Plan (July 1994)
[Archived Article]
In TAGline, from Treatment Action Group
AIDS Clinical Trials Group Scramble to Convince Industry They Can Produce (June 1994)
[Archived Article]
In TAGline, from Treatment Action Group
The Crisis in Clinical AIDS Research (December 1993)
[Archived Article]
In TAGline, from Treatment Action Group

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