HIV/AIDS Clinical Trials
The Basics
- Information on Clinical Trials and Research (Regularly Updated)
From National Cancer Institute
- How HIV Drugs Get Approved (August 9, 2009)
To read PDF, click here
From AIDS InfoNet
- Understanding Clinical Trials (September 20, 2007)
From U.S. National Institutes of Health
- Should I Join a Clinical Trial? (Winter 2006/2007)
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
- Getting It Right: Being Smarter About Clinical Trials (June 2006)
In PLoS Medicine
- Virtual Monotherapy: Can It Be Avoided in Clinical Trials? (Spring 2006)
If you have multidrug resistance, joining a clinical trial for a drug in development may carry risks as well as benefits.
To read PDF, click here
In ACRIA Update, from AIDS Community Research Initiative of America
- Joining a Clinical Trial: Asking the Right Questions (January-March 2006)
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Let's Talk About It: Learning to Trust, Again (July/August 2004)
[Archived Article]
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Who Are We Hurting: The Hesitation by People of Color (July/August 2004)
[Archived Article]
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Clinical Trials: Making Them Work for You (January/February 2004)
In Survival News, from AIDS Survival Project
- Should You Enroll in a Clinical Trial? (September/October 2002)
In Positive Living, from AIDS Project Los Angeles
- Out of the Laboratory and Into the Bathroom Cabinet: Designing and Implementing Clinical Trials (Summer 2002)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
- Independent Review of Research Data (February 2002)
[Archived Article]
The safeguards that work to ensure clinical trial results are complete and accurate.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Clinical Studies (December 2001)
[Archived Article]
In WISE Words, from Project Inform
- Rights and Responsibilities of Research Participants (December 2001)
[Archived Article]
In Body Positive, from Body Positive
- A Long Road Traveled: Conflicts, Community and Clinical Trials (Summer 2001)
[Archived Article]
To read PDF, click here
In CRIA Update, from AIDS Community Research Initiative of America
- FDA Discusses Trial Design for Salvage Therapy (April 2001)
[Archived Article]
In TAGline, from Treatment Action Group
- Protecting Human Research Subjects (June 6, 2000)
[Archived Article]
From U.S. Department of Health and Human Services
- Clinical Trials and Industry Influence: Major Report (June 2, 2000)
[Archived Article]
A study raises alarm about how pharmaceutical companies influence clinical trials in order to increase drug sales.
In AIDS Treatment News, from AIDS Treatment News
- Long-Term Effectiveness Clinical Trials in HIV/AIDS (Spring 2000)
[Archived Article]
Improving the quality of survival. The community sends a consensus statement to the National Institutes of Health.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- A Comprehensive Look at Clinical Trials (2000)
From AIDS Community Research Initiative of America
- Experimental Treatments: Unapproved but Not Always Unavailable (January/February 2000)
[Archived Article]
In FDA Consumer, from U.S. Food and Drug Administration
- The Healing Power of Placebos (January/February 2000)
[Archived Article]
In FDA Consumer, from U.S. Food and Drug Administration
- Clinical Trials vs. the Clinic (October 1999)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
- The Nuts and Bolts of Clinical Trials (Fall 1999)
[Archived Article]
In Women Alive Newsletter, from Women Alive
- Fact Sheet: AIDSTRIALS and AIDSDRUGS (April 1998)
[Archived Article]
How to search these databases for information on studies of experimental treatments.
From U.S. National Institutes of Health
- FDA Publishes Conflict of Interest Rules for Clinical Trials (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Should You Participate in Clinical Trials? (December 1997)
In AIDS Care, from San Francisco General Hospital
Personal Accounts
News/General Articles
- American Medical News Examines Clinical Trials Outsourcing (September 9, 2009)
In Kaiser Daily Global Health Policy Report, from Henry J. Kaiser Family Foundation
- Prepping for a PrEP Trial (July/August 2009)
Why is it so hard to find young people to participate in HIV-related studies? While trying to find an assistant to help recruit young, gay men for a trial of pre-exposure HIV prophylaxis (PrEP), HIV advocate Keith Green may have stumbled on an answer: homophobia.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- After 25 Years, a Landmark HIV Study Is Still Going Strong (April 25, 2009)
The Multicenter AIDS Cohort Study (MACS) is one for the history books: It's one of the most important HIV/AIDS studies ever done, and over the past 25 years it has brought about many major discoveries.
From National Public Radio
- ACRIA Trials In Progress (Fall 2008)
To read PDF, click here
In Achieve, from ACRIA and GMHC
- Clinical Trials Units Selected for Newly Restructured HIV/AIDS Research Networks (March 14, 2007)
From U.S. National Institutes of Health
- Moving Toward Assured Access to Treatment in Microbicide Trials (July 11, 2006)
In PLoS Medicine
- Kaiser Daily HIV/AIDS Report Summarizes Opinion Pieces on NIH-Funded AIDS Drug Trials Involving Foster Children (May 24, 2005)
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation
- Clinical Trials: Philadelphia Hospitals Combine to Form "Supersite" and Reduce Delays (September 15, 2004)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Smarter Clinical Trials for Faster Drug Development (August 23, 2004)
[Archived Article]
Experimental drugs are being tested in humans earlier in the development process, which can help speed the drugs' progress -- or their demise.
In AIDS Treatment News, from AIDS Treatment News
- Conducting Clinical Trials Without Ethical Review (July 2004)
[Archived Article]
A recent series of unethical -- even illegal -- clinical trials in India is fueling concern over the "outsourcing" of studies to countries where study regulation is lax.
To read PDF, click here
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- Joining a Preventive HIV Vaccine Clinical Trial: Benefits and Risks (May 2004)
[Archived Article]
To read PDF, click here
In WISE Words, from Project Inform
- Joining a Therapeutic HIV Vaccine Clinical Trial: Benefits and Risks (May 2004)
[Archived Article]
To read PDF, click here
In WISE Words, from Project Inform
- Scramble for Africa (May/June 2004)
[Archived Article]
Gregg Gonsalves says a new kind of colonialism, not humanitarianism, is behind the U.S.'s new push for HIV treatment research in the developing world.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- CDC Offering $500,000 for Web-Based Studies of Men Who Have Sex With Men (July 21, 2003)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Volunteers for New HIV Drugs Get Harder to Find (June 9, 2003)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Africa: Problems Getting Antiretrovirals for Trials (May 30, 2003)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- New Guidance on Clinical Trial Design in Developing Treatment for HIV Infection (November 1, 2002)
[Archived Article]
From U.S. Food and Drug Administration
- Florida: Wansiki Foundation's Fort Lauderdale Clinic Offers HIV-Treatment Trials (October 8, 2002)
[Archived Article]
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention
- Improving Informed Consent: Insights From Behavioral Decision Research (October 2002)
[Archived Article]
An abstract from Medical Care.
In IAPAC Monthly, from International Association of Physicians in AIDS Care
- HIV Clinical Trials: Are They Still Needed? (Spring 2002)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
- Major AIDS Studies to Increase Minority Enrollment, Answer New Questions (September 10, 2001)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Death as an Endpoint (September 2001)
[Archived Article]
Killing PWAs for science, or providing information to prolong life?.
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Learning Basic Science From Clinical Trials (July 8, 2001)
[Archived Article]
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO
- Report From the Adult AIDS Clinical Trials Group (AACTG) Meeting (July/August 2001)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- It's Time for New Leadership at the AACTG (May 2001)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- In for the Long Haul: Debate Paves Way for Long-Term Trials (Spring 2001)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
- SMART Study: Background, Concepts, and Design (Spring 2001)
[Archived Article]
In Research Initiative/Treatment Action!, from The Center for AIDS
- 2000: A Year of Endings and Beginnings (January/February 2001)
[Archived Article]
Developments in structured treatment interruptions, new treatments, clinical trial enrollment and treatment for Africa.
To read PDF, click here
In Positively Aware, from Test Positive Aware Network
- Clinical Trials and Industry Influence: Major Report (June 2, 2000)
[Archived Article]
A study raises alarm about how pharmaceutical companies influence clinical trials in order to increase drug sales.
In AIDS Treatment News, from AIDS Treatment News
- AIDS Research Consortium of Atlanta Enrolls 50,000th Patient in National HIV/AIDS Study (March 2000)
[Archived Article]
In Survival News, from AIDS Survival Project
- OCS Redux: International Statistical Panel Puts Observational Cohort Study Research Possibilities into Perspective, Identifies Limitations (March 2000)
[Archived Article]
In TAGline, from Treatment Action Group
Clinical Trials: 1997 - 1999
- NIAID Renews Funding for the Adult AIDS Clinical Trials Group (December 22, 1999)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- New amfAR Treatment Directory Now Available (October 1, 1999)
[Archived Article]
From AIDS Treatment News
- Strategy Trials: The Answer? (February 18, 1999)
[Archived Article]
From AIDS Treatment News
- NIAID Opens First AIDS Vaccine Trial in Africa (February 8, 1999)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- Trials & Errors: Studies Look at Which Combinations Are Better (February 1999)
[Archived Article]
Clinical trials using NNRTIs with or instead of protease inhibitors.
From Seattle Treatment Education Project
- Improving Drug Development: Exploratory Clinical Studies (January 8, 1999)
[Archived Article]
From AIDS Treatment News
- ACTG Salvage Therapy Trials (January 1999)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Primary Infection Clinic Enrolling for NIH Studies (Winter 1998)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
- Trials Now Enrolling (Fall 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
- AIDS Diarrhea: Phase III Trial Recruiting in Over 30 U.S. Sites (July 17, 1998)
[Archived Article]
From AIDS Treatment News
- Prospective Case Series in Clinical Trial Design -- Proposal, and NTZ Example (June 5, 1998)
[Archived Article]
From AIDS Treatment News
- Trials Now Enrolling (Summer 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
- Hepatitis C and HIV: Ribavirin Plus Interferon Study Recruiting (May 15, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- IL-2 Without Antiretroviral Therapy: Trial Near Washington, D.C. (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Oral Contraceptive / Nevirapine Interaction Trial (March 6, 1998)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Trials Now Enrolling (Spring 1998)
[Archived Article]
In CRIA Update, from AIDS Community Research Initiative of America
- Selected Clinical Trials Open to Patients with HIV Disease (February 1998)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
- Protease Inhibitor Failure Trial: Combination 1592, 141W94, and Efavirenz (December 5, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Fortovase Approved: New Saquinavir Formulation (November 21, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Pregnant Women Eligible for Single-Dose Nevirapine Study (October 3, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Adefovir Dipivoxil Trials: CD4 100-500, Protease Inhibitor Naive (September 5, 1997)
[Archived Article]
From AIDS Treatment News
- DMP 266 Trials Recruiting, Many Cities -- Protease Inhibitor Naive (September 5, 1997)
[Archived Article]
From AIDS Treatment News
- CMV Trials Struggle to Enroll (September 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Equality in Clinical Trials: Drugs and Gender (September 1997)
[Archived Article]
From U.S. Food and Drug Administration
- IL-2 for HIV: The Long March Toward FDA Approval (September 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Major Pediatric Study Stopped Early: Combination Treatment Better (July 4, 1997)
[Archived Article]
From AIDS Treatment News
- Saquinavir: Major Study Shows Survival Benefit in Treatment-Naive Patients (July 4, 1997)
[Archived Article]
From AIDS Treatment News
- FDA Explores New Antiretroviral Trial Designs: Interview with David Feigal, M.D. (June 20, 1997)
[Archived Article]
From AIDS Treatment News
- Clinical Trials and Viral Load: Statement for FDA Community Meeting May 16 (May 16, 1997)
[Archived Article]
From AIDS Treatment News
- CMV Retinitis, Newly Diagnosed: RS-79070 Trial (May 1, 1997)
[Archived Article]
From AIDS Treatment News
- CMV, RS-79070: Community Concern As Major Drug's Development Suspended (May 1, 1997)
[Archived Article]
From AIDS Treatment News
- ACTG 268: Gradual vs. Routine Initiation of Prophylaxis (April 1997)
[Archived Article]
In HIV Newsline, from San Francisco General Hospital
- Government Study Finds Protease Based Triple Combination Keeps Patients Alive Longer Than Double Nuke (April 1997)
[Archived Article]
From Treatment Action Group
- Protease Inhibitors: Major Study Stopped When 3-Drug Arm Proves Superior (March 7, 1997)
[Archived Article]
From AIDS Treatment News
- Data reviews halt three trials earlier than planned: ACTG 320, Merck Protocol 028 (March 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Study Confirms that Protease Inhibitor Cocktail Can Delay HIV Disease Progression and Death (March 1997)
[Archived Article]
From U.S. National Institute of Allergy and Infectious Diseases
- The Need for 'Strategy' Type Clinical Studies (March 1997)
[Archived Article]
From Treatment Action Group
- Adefovir Dipivoxil: Broad-Spectrum Antiviral Trial, CD4 Count Under 100 (February 7, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Nelfinavir: Agouron Announces Expanded Access for Children, a Major New Trial, and Enlarged Expanded Access for Adults (January 17, 1997)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- AVANTI 1 Shows Immunological Benefit for Loviride (January 1997)
[Archived Article]
In The 4th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Clinical Trials and Studies Seeking Patients (Winter 1996/1997)
[Archived Article]
In STEP Perspective, from Seattle Treatment Education Project
- Commentary: Reinventing Expanded Access [sections on Nevirapine, Nelfinavir, 141W94, 1592U89, and Adefovir (January 1997)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Final Results of CAESAR Study Demonstrate a Survival Benefit with 3TC (January 1997)
[Archived Article]
In The 4th Conference on Retroviruses and Opportunistic Infections, from The Body PRO
- Studies Find D4T Plus 3TC Effective Against HIV (January 24, 1997)
[Archived Article]
From amfAR, The Foundation for AIDS Research
Clinical Trials: 1996
- Nevirapine Trial Confirms Dr. Schooley's Point (December 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- 1592: Two Studies Recruiting (November 15, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Cytarabine Nixed for PML (November 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Nerve Growth Factor Study Opens (November 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Nelfinavir Expanded Access Program (October, 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Nelfinavir (Viracept) Expanded Access Announced (September 19, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- CAESER Study Completed (September 1996)
[Archived Article]
In Hopkins HIV Report, from Johns Hopkins AIDS Service
- 1592 -- New Experimental Antiretroviral (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Five-Drug or Six-Drug Antiretroviral Therapy -- Conversation with Steven Scheibel, M.D. (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Nelfinavir Protease Inhibitor Study Recruiting (August 23, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Another Call for Strategy Trials (August 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- NAC: First Controlled Trial, Positive Results (July 5, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Protease Inhibitors: Ritonavir and Saquinavir Combination Trial Recruiting (April 19, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- California: Clinical Trials Computer Service Now Available Statewide (April 5, 1996)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Pediatric Treatment Update (March 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- ACTG Oncology Committee Finds New Home at National Cancer Institute, But Funding Is Woefully Inadequate (February 1996)
[Archived Article]
In TAGline, from Treatment Action Group
- Curcumin Trial Finds No Activity (February 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- Hydroxyurea Continues to Show Promise (February 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
- New Anti-HIV Vaccine and KS Trials at the National Cancer Institute (February 1996)
[Archived Article]
By Robert Yarchoan, M.D., Chief, Retroviral Diseases Section, MB, DCS.
From National Cancer Institute
- The First Integrase Inhibitor (January 1996)
[Archived Article]
In GMHC Treatment Issues, from Gay Men's Health Crisis
Clinical Trials: 1993
- ACTG Clinical Trial Sites: Seven Cut, Two Added (December 22, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Peptide T: Negative Trial Result (November 3, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Viral Load: New "Strategy" Trial in 15 U.S. Cities (October 20, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Symptom-Reduction Trials at FDA Clinical Trials Workshop (September 29, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- "Confirmatory" Trials: Symptom Reduction As Efficacy Measure (August 18, 1995)
[Archived Article]
In AIDS Treatment News, from AIDS Treatment News
- Re-Inventing Government: New ACTG Structure Squeezes Eleven (February 1995)
[Archived Article]
Committees Into Three--But Will Anything Really Be Any Different?.
In TAGline, from Treatment Action Group
- AIDS Clinical Trials Group Ready Themselves for 1996-2001 Funding (November 1994)
[Archived Article]
In TAGline, from Treatment Action Group
- AIDS Clinical Trials Group Rescue Plan (July 1994)
[Archived Article]
In TAGline, from Treatment Action Group
- AIDS Clinical Trials Group Scramble to Convince Industry They Can Produce (June 1994)
[Archived Article]
In TAGline, from Treatment Action Group
- The Crisis in Clinical AIDS Research (December 1993)
[Archived Article]
In TAGline, from Treatment Action Group
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