Medications That Should Not Be Used With: Saquinavir (Invirase), Indinavir (Crixivan), Ritonavir (Norvir)
Saquinavir (Invirase, Fortovase)
| Drug Category |
Potential Alternatives |
|
Antimycobacterial (anti-TB or anti-MAC):
rifampin (Rifadin, others),
rifabutin
|
azithromycin (Zithromax),
ethambutol (Myambutol) |
|
Sedative/hypnotic:
midazolam (Versed),
triazolam (Halcion)
|
very limited clinical experience |
| Ergot derivatives (anti-migraine): |
very limited clinical experience |
|
Cold and allergy antihistamines:
astemizole (Hismanal),
terfenadine (Seldane)
|
loratadine (Claritin) |
|
Gastrointestinal:
|
very limited clinical experience |
Indinavir (Crixivan), Nelfinavir (Viracept)
| Drug Category |
Potential Alternatives |
|
Antimycobacterial (Anti-TB or anti-MAC):
rifampin (Rifadin, others)
|
clarithromycin (Biaxin)
azithromycin (Zithromax)
ethambutol (Myambutol) |
|
Cold and allergy antihistamines:
astemizole (Hismanal),
terfenadine (Seldane)
|
loratadine (Claritin) |
|
Gastrointestinal:
|
very limited clinical experience |
| Sedative/hypnotic |
midazolam (Versed)
triazolam (Halcion) |
Ritonavir (Norvir)
| Drug Category |
Potential Alternatives |
|
Analgesic (pain reliever):
meperidine (Demerol)
piroxicam (Feldene)
propoxyphene (Darvon, others)
|
acetaminophen (Tylenol, others)
aspirin (Bayer, others)
oxycodone (Percocet, others) |
|
Cardiovascular (for the heart):
amiodarone (Cordarone)
flecainide (Tambocor)
propafenone (Rythmol)
quinidine (various)
|
very limited clinical experience |
|
Antimycobacterial (Anti-TB or anti-MAC):
|
clarithromycin (Biaxin)
azithromycin (Zithromax)
ethambutol (Myambutol) |
|
Calcium Channel Blocker (for the heart):
|
very limited clinical experience |
|
Ergot Alkaloid (vasoconstrictor):
dihydroergotamine (D.H.E. 45)
Ergotamine (various)
|
|
|
Cold and allergy antihistamines:
astemizole (Hismanal),
terfenadine (Seldane)
|
loratadine (Claritin) |
|
Gastrointestinal:
|
very limited clinical experience |
|
Psychotropic (antidepressant):
|
fluoxetine (Prozac)
desipramine (Norpramin) |
|
Psychotropic (neuroleptic):
clozapine (Clozaril)
pimozide (Orap)
|
very limited clinical experience |
|
Sedative/hypnotic:
alprazolam (Xanax)
clorazepate (Tranxene)
diazepam (Valium)
estazolam (ProSom)
flurazepam (Dalmane)
midazolam (Versed)
triazolam (Halcion)
zolpidem (Ambien)
|
Temazepam (Restoril)
Lorazepam (Ativan) |
* Please note that alternatives may not be therapeutically equivalent
References: Product Labeling
Invirase™ (December 6, 1995)
Norvir™ (March 1, 1996)
Drug Interactions: Physician Guide
Crixivan™ (March 13, 1996)
Fortovase™ (November 7, 1997)
Drugs That May Interact With Ritonavir
The following is a list of medications that may potentially interact with ritonavir therapy.
| Drug Category |
Drugs that may interact with ritonavir (Norvir) |
| Analgesics, Narcotics (pain relievers) |
alfentanil (Alfenta)
fentanyl (Sublimaze) |
| Antiarrhythmics (for the heart) |
disopyramide (Norpace)
lidocaine (Xylocaine, others) |
| Anticoagulants (for the blood) |
R-warfarin (Coumadin) |
| Anticonvulsants |
carbamazepine (Tegretol)
clonazepam (Klonopin)
ethosuximide (Zarontin) |
| Antihistamine |
loratadine (Claritin) |
| Antidepressants, other |
nefazodone (Serzone)
sertraline (Zoloft)
trazodone (Desyrel) |
| Antiemetics |
dronabinol (Marinol)
ondansetron (Zofran) |
| Antimycobacterial (anti-TB or anti-MAC) |
rifampin (Rifadin, others) |
| Antiparasitics |
quinidine (various) |
| Calcium Channel Blockers |
amlodipine (Norvasc)
diltiazem (Cardizem, Diltiazem)
felodipine (Plendil)
isradipine (DynaCirc)
nicardipine (Cardene)
nifedipine (Adalat, Procardia)
nimodipine (Nimotop)
nisoldipine (Sular)
verapamil (Calan, Isoptin) |
| Cancer chemotherapeutic agents |
etoposide (VePesid)
paclitaxel (Taxol)
tamoxifen (Nolvadex, others)
vinblastine (Velban)
vincristine (Oncovin) |
| Corticosteriods |
dexamethasone (Decadron, others)
prednisone (various) |
| Hypolipidemics |
lovastatin (Mevacor)
pravastatin (Pravachol) |
| Immunosuppressants |
cyclosporine (Sandimmune, Neoral)
tacrolimus (Prograf) |
Drugs That May Interact With Nelfinavir
The following is a list of medications that may potentially interact with nelfinavir therapy.
| Drug Category |
Drugs that may interact |
| Anticonvulsants |
carbamazepine (Tegretol)
phenobarbital
phenytoin (Dilantin) |
| Anti-HIV protease inhibitors |
indinavir (Crixivan)
ritonavir (Norvir) |
| Oral contraceptives (birth control pills) |
ethinyl estradiol
norethindrone |
.
