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Zidovudine Toxic Effect

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Mitochondrial Toxicity

... What Are Mitochondria? What Is Mitochondrial Toxicity? What Are the Signs of MT? How Do ARVs Cause MT? What's Next? What Are Mitochondria? Mitochondria (my-toe- con' -dree-a) are small "organs" in our cells. They are the cell's power plant. They use oxygen, fat and
Ask the Experts

is AZT toxic

To Dr. Franscino: My Hiv specialist told me that over a period of time AZT can be toxic as it builds up in a persons system. My question is, is this true, and if it is true, why even use a drug that over time can prove to be toxic?
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...up in a person's system" over time. AZT, like a great many other drugs, can have short- and long-term side effects as well as toxicities. Common AZT side effects would be anemia (which can come on rapidly after starting the drug) and lipoatrophy... Read more »

Toxic Effects

Hello docs,Im trying to deal with my hiv positive status the best I can...Im trying to get rid of the recreational drug and alcoohol abuse!But I cant stop worrying about what Ive heard from a friend once that told me you either dye from the hiv or...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
HIV therapies are steadily getting easier and safer and more effective. It is not true that patients have a choice between dying of AIDS or side effects of the disease. Some patients survive long term with HIV even without treatment so the dying... Read more »

why these toxic side effects.why?

dr bobthanks for your work on this site.really appreciated.i need ur quick opinion on this.despite of huge advancement in medicine(science)why IS IT difficult for these doctors and scientists to develop anti-hiv drug thats free of toxic side...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...therapies to help control HIV and decrease both HIV/AIDS morbidity and mortality. That these potent therapies have side effects/toxicities is not surprising. I don't know of any effective medication for any medical condition that doesn't have... Read more »

Long-term Side Effects?"Toxic Trauma?"

Dr., I have been off all HIV meds for about two months due to, too many side effects. I am now experiencing problems with my abdomin, and more body pain and serious fatigue. Is this something that could be permanent? I have been on and off...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Tough to say what is contributing to your symptoms. Advanced HIV/AIDS clearly is associated with many GI problems, weight loss, diarrhea, and pains. For most of the HIV medications if they were contributing significantly to your side effects then... Read more »
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the mitochondria. We have learned in the past that the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss... Read more »
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...called polymerase gamma to reproduce. Almost all nucleoside analogue drugs (NARTIs) such as 3TC (lamivudine, Epivir®), AZT (zidovudine, Retrovir®), abacavir (Ziagen®), d4T (stavudine, Zerit®), ddC (zalcitabine, Hivid®), and ddI (didanosine,... Read more »
Brown Medical School

Long-Term Toxicities Associated With HIV and Antiretroviral Therapy

...References Introduction Soon after the introduction of the first antiretroviral (ARV) agent, zidovudine (AZT), drug-related toxicities became recognized and well-characterized. Things have since become more complicated; there are now 17 ARV... Read more »
Canadian AIDS Treatment Information Exchange

Can Uridine Supplements Protect People With HIV/AIDS From Drug Toxicity?

...2004;18(7):1085-1086. Dagan T, Sable C, Bray J and Gerschenson M. Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence? Mitochondrion 2002;397-412. Brinkman K, Vrouenraets S, Kauffmann R, et al.... Read more »
Connect With Others

A Toxic Combination

Posted by Choosing2Liv, 9 Replies
If my dilemma was: - just dealing with the virus; or - just suffering with the guilt of cheating on my wife; or - just the feelings of rejections by those who said they loved me; or - just the constant blaming, belittlement and bursts of rage... Read more »

Toxicity: Your Experiences

Posted by Anonymous
...might be available in a new study on a once daily dosing schedule. My question is, what do u think about drug side effects/toxicity over the long term? Does anyone do a combo like this? Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies
Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »


Posted by Anonymous
...for acute HIV infection may be in a more favorable position when a cure is finally found,21 because they have been spared the toxicities of potent drugs, have avoided the development of drug-resistant HIV and have not suffered the stress of... Read more »