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Will PIs Help Me

Here's a taste of what has to offer on this topic:
Ask the Experts


Dr Wohl,I can't thank you enough for taking the time to help with my education. There is SO much to learn...You recently answered my question on Integrase Inhibitor action (THANKS!)Now I don't understand how using an NNRTI&NRTI (or even...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
...The NRTIs, NNRTIs and PIs all work to prevent the virus from making copies of itself in cells. The NRTIs and NNRTIs work at an early stage, soon after Read more »

Which Boosted PI

I am about to start first line treatment with either atazanavir or saquinavir (boosted with... Read more »

Wellbutrin/PI's and Neuropathy

I read a brief question about Wellbutrin and neuropathy and the answer said that caution should be... Read more »
The Body PRO

Dual-PI Regimen Preferred Over Single-PI Regimen After Initial PI Failure

...previously achieved an undetectable HIV RNA (less than 500 copies/mL). The treatment arms included one new PI versus two new PIs, both in combination with an NNRTI and one or more nucleosides. At 12 months, the percentage of patients achieving an... Read more »
International Association of Physicians in AIDS Care

Fosamprenavir: A New PI Option

... The improved tolerability, dosing flexibility, and resistance properties of new protease inhibitors (PIs) have triggered a reassessment of the role that PIs may play in first- and second-line antiretroviral therapy. The US Food and Read more »
The Body PRO

Switch Study Shows Improved Suppression and Adherence Rates With Once-Daily Efavirenz-Based Regimens Vs. Most PI-Based Regimens

...that did not contain either a boosted PI or atazanavir (ATV, Reyataz), these results can be seen as guiding primarily those on PIs other than these, since the potency and success of these newer approaches may alter how much of a difference we... Read more »
The Body PRO

Initial Data on TMC114 in Multiple PI-Experienced Patients

...still become useful drugs. So it has been with the protease class. In the middle of 2003, there are two protease inhibitors (PIs) in human testing with activity against multiple-PI-resistant virus. One is tipranavir ( click here for IAS coverage... Read more »
Connect With Others

PI Monotherapy advice

Posted by logopolis, 2 Replies
Admin OptionsEdit Discussion Close Discussion Edit Your Tags Cancel Delete Discussion Hi, My partner has been asked to take part in a clinical trial - Protease Inhibitor monotherapy versus Triple Therapy. Just gathering some info before he... Read more »

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies
...on Friday approved the use of a new HIV drug, made by Johnson & Johnson <JNJ.N>, in combination with related therapies to help treat patients who do not first improve with other treatment. The drug, Prezista, is a protease inhibitor... Read more »

P.I. versus NNRTI

Posted by Anonymous, 2 Replies
Hi. I am hearing a lot of good things about the Truvada + Reyataz + Norvir combo. I am just about to commence my first line regimen, and wanted to enquire as to what anybody else thought of this combo? I am starting therapy with a relatively high... Read more »

crixibelly and buffalo back

Posted by Anonymous, 2 Replies
Hey Guys: I am looking for ANY information on the layer of FAT you get on your belly from protease inhibitors. The news just gets worse because you get a layer of fat on the back of your neck, too.... Read more »