Will Enfuvirtide Help Me

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Enfuvirtide (Fuzeon)

What Is Enfuvirtide? Enfuvirtide, also called Fuzeon® or T-20, is a drug used for antiviral therapy. It is manufactured by Roche and Trimeris. Enfuvirtide is the first "fusion inhibitor" drug. When HIV infects a cell, it attaches to the outside of the cell. Then it "fuses" or joins itself with the cell. Enfuvirtide stops this process of fusion. This means that HIV cannot infect that cell. Who Should Take It? Enfuvirtide was approved in...

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Injection of T-20 (Enfuvirtide)

Hello, I'm a physician treating a patient with T-20. The injections have been causing him reactions at the site - namely erythema, nodules, pruritus, ecchymosis, pain and discomfort. What techniques do you use or recommend to lessen these...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Some patients have reported less ISRs with use of the BioInjector system for Fuzeon (an air gun). Cooling the inject site with ice packs for some while for others heat/message has helped. Since there likely will be a number of new HIV drugs active... Read more »

Please help me help my partner

My partner of 7 years has become resistant to almost everything. He is waiting to see if he meets the criteria for a local study where he will receive Temprenavir and T-20. His HMO can provide the T-20 but the other med has not been released for...

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital

Weight loss in the setting of poorly controlled HIV has been demonstrated to be predominantly related to poor intake in the absence of any significant diarrhoeal illness. Clearly things that will help improve in take of nutrients is critical so if... Read more »

T-1249 how can we help bring this product to faster approval in US?

Dr. Young,I have heard that t-1249, t-20's cousin is more potent in clinical trials? I was wondering what have you heard about this compound and also how can we help in bringing this hiv product to approval faster.And Dr. Young, this is for...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

T-1249 is the second fusion inhibitor from Roche-- the follow up to enfuvirtide. Very promising potency and resistance properties have been shown in clinical trials (see our conference coverage for more details).Your question about how to bring... Read more »

Need help formulating regimen

I am on Kaletra, Viread, 3tc, T-20, Famvir, Endurancin, and a host of supplements. I added Kaletra to the current regimen in 12-2003 after the viral load shot up over 100,000. Viral load dropped to 900+ and T-Cells climbed from 105 to 430 by June...

Response from Eric Daar, M.D.

UCLA School of Medicine

Although you did not tell me your most recent CD4 cells or viral load, I can make some general comments related to your questions. Based upon what you tell me it seems unlikely that you could start a new regimen with currently approved drugs that... Read more »

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