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Why Patient Have Hiv Increase Cd8

Here's a taste of what has to offer on this topic:
amfAR, The Foundation for AIDS Research

Focusing on CD8: The "Other T Cell" in HIV Infection

Two types of T cells are critically important in HIV infection. Most discussion of these immune cells refers to the subset known as CD4+, which is the cell type counted during most patient visits to gauge when to start antiretroviral therapy and the... Read more »
Treatment Action Group

More on the Links Between the CD4/CD8 Ratio, Immunological Perturbations, and Risk of Illness and Death

Since posting recently about studies investigating the relevance of the CD4/CD8 ratio in the antiretroviral therapy era, several new papers and presentations have provided more information on the topic. Last week in the open access journal PLoS... Read more »

Non-Hodgkin's Lymphoma Rates Lower in HAART-Treated Patients

Background Untreated HIV infection confers a huge increase in the incidence of non-Hodgkin's lymphoma (NHL). Understanding the extent to which HAART mitigates this risk is of vital importance to HIV-infected persons. Details of This Study Waterson... Read more »
Ask the Experts

what happens when cd4/cd8 ratio is 0.24

sir, i am hiv-2 positive patient and also affected with TB (which has been treated recently before 3 months).taking treatment for hiv ,before my cd4 and cd8 ratio was 0.49 but now it has been drastically changed to as belownow my cd4 cells-177and...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
I am not clear as to whether you are currently receiving TB and HIV meds and what your CD4 count was before. If so, it might be a drug reaction causing a decline in your cell count. On the other hand, if your CD4 count has not changed, but just your... Read more »

CD8 and CD8%

I have never understood the cd8 number and what the percentage means. Can you answer generally what they are used for and why they are valuable? If you could comment specifically on my latest lab numbers that would be great.% CD3...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
In many people with HIV infection, the CD8 count and percent increase as a reaction to the infection. CD8 cells are the major type of cell involved with controlling the infection. So that is why you see an increase.... Read more »

Re:CD4/CD8 ratio and CD4 percentage

Dear Mark - thankyou very much for answering my question so quickly - I just have a couple more questions for clarification.You mentioned with HIV infection the CD8 cells increase and the CD4 cells fall leading to a fall in the CD4/CD8 ratio - how...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Your ratio is still normal. It usually takes years to fall significantly. CD4 percentage falls about 1-3%/year in the absence of treatment. We don't really know what the fall in CD4 count in you is, because we don't have a preinfection CD4... Read more »

CD8 significance

I understand that HIV infection generally makes CD4 counts decline and CD8 counts increase. With successful treatment this trend reverses, i.e. the ratio of CD4 to CD8 increases. Normal is between 1 and 6.Looking at my results over the past 5 tests...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thanks for posting.I'm with your doctor. Your overall results, especially your CD4 count and CD4/CD8 ratio are all in the normal range. BTW, I'd double check your normal ranges for the ratio- I'm happy if my patients are... Read more »
Connect With Others

cd4/cd8 count results.. still hiv negative.

Posted by Jackson8811, 2 Replies
Here are my blood results i today got back from my doctor. He was concerened...

cd4 total count - 470
cd4% - %39
cd8% - %28
cd8 total count 300

Soo.. my cd4 is low at 470.. and my cd% is rather normal at 39 percent... could these results have any... Read more »

POZ + big lower cheeks + high CD8 count = DILS

Posted by BabyPeanut, 1 Reply
If you are infected with HIV and have developed swollen cheeks and a
high CD8 count that does not go away with time then you probably have
DILS. Fortunately, unless it turns into cancer, DILS is harmless. It
is a good idea to have your doctor confirm... Read more »


Posted by Anonymous, 3 Replies
Does anybody know what other viral infections apart from HIV can cause an inverted CD4:CD8 ratio?
Read more »