Who Makes Stavudine

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Stavudine (Zerit)

What Is Stavudine? Stavudine (Zerit) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. The original patent on stavudine has expired. The U.S. Food and Drug Administration (FDA) approved generic forms of stavudine for sale in the U.S. and under PEPFAR (see Fact Sheet 475 ). Stavudine is also known as d4T or didehydro-deoxythymidine. Stavudine is the most commonly used anti-HIV medication...

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Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God bless. ...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, there's no particular reason why the two drugs couldn't be... Read more »

Forgot dose of stavudine (2 hours)

I forgot to take my stavudine dose on time and I ended up taking it 2 hours later. What is the probability of this causing resistance? Is there a window of time to take the missed dose that is relatively safe? Thank you....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Should not be a problem. KH... Read more »

resistance to stavudine

Is there any data that explains why some patients experience clinical failure on a regimen containing stavudine if there are no clinically observed codon mutations linked to stavudine resistance?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Good question and hard to get an answer. A couple of points though. Although we can't seem to find the mutation we believe causes d4T resistance in the test tube in people, we see the cases you describe. This may be related to other mutations... Read more »

Stavudine toxicity

what can used in conjuction with lamivudine, stocrin in place of stavudine?What do we need to do to prevent pre-mature aging of body cells?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

If available and depending on the nature of the problems with stavudine, it is most often switched to tenofovir or abacavir (if HLA B5701 negative or low risk for hypersensitivity reactio) or ziduvudine. Avoiding premature aging in the setting of... Read more »

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