Who Is At Risk For Mitochondrial Toxicity

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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mitochondrial toxicity and fatigue

Would a one week on "Meds" one week off "meds" be sufficient to slow reverse or halt this disintegration of the Mitochondria ? Regardless of the "it's BAD to stop meds because you will develope a resistant strain !!...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

OK, OK, OK, I get it! You don't want me to say it's BAD to stop meds, because you will develop a resistant strain!!! However, you want me to comment on one-week-on and one-week-off H"IV meds and advise you if this theoretically might... Read more »

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Clinical assessment as well as venous lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on... Read more »

MITOCHONDRIAL TOXICITY

Anti-HIV drug side effects linked to mitochondrial toxicity have been around for years. It is obvious with the growing incidence and possible role of lipodystrophy. It's a fact that all nukes inhibit cellular DNA polymerase beta and gamma, thus...

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital

This rather a long question so I hope I can respond to all of it.The risk factors for lipoatrophy inlcude disease characteristics (AIDS, low CD4), genetic characteristics (genes which promote the pro-inflammatory cytokine TNF) and both nucs and PIs.... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...

Response from Alvan Fisher, M.D.

Brown University School of Medicine

No, not routinely.Alvan Fisher, M.D.... Read more »

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Toxicity: Your Experiences

Posted by Anonymous

Ok.

I recently tested positive and even though my viral load under 2,000 i have a 389 CD4.

I have been investigating epivir/ziagen and viread..they might be available in a new study on a once daily dosing schedule.

My question is, what do u think about... Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies

Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies

If my dilemma was:

- just dealing with the virus; or

- just suffering with the guilt of cheating on my wife; or

- just the feelings of rejections by those who said they loved me; or

- just the constant blaming, belittlement and bursts of rage from my... Read more »

Low Risk/High Risk

Posted by Anonymous, 1 Reply

What does Low Risk/High Risk mean? I mean, how many low risk people turn positive? Obviously, high risk people have a better chance of testing positive, but does low risk mean that the risk is virtually none? Thanx.

Read more »

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