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What Is Mitochondrial Toxicity

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Get the Facts
AIDS InfoNet

Mitochondrial Toxicity

... What Are Mitochondria? What Is Mitochondrial Toxicity? What Are the Signs of MT? How Do ARVs Cause MT? What's Next? What Are Mitochondria? Mitochondria (my-toe- con' -dree-a) are small "organs" in our cells. They are the cell's power plant. They use oxygen, fat and sugar...scientists believe that mitochondria are the key to aging. As we grow older, our mitochondria collect more and more mutations. Our cells have a way to...
Ask the Experts

mitochondrial toxicity

if it is thought that some nukes cause mitochondrial toxicities/deficiencies. can these problems interfere with the muscles ability for strenght and growth, ie. the ability to weight train?reason being is that I have had extensive fat loss on my...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There have been some reports of impaired/slowed muscle recovery in the setting of mitochondrial toxicity. In addition, I have cared for some patients who report and have exhibited that phenomenon. It seems to be variable and is often Read more »

Growing concern around mitochondrial toxicity

I have been on truvada and sustiva for 9 months and for the past few weeks have been experiencing muscle aches and weakness in both legs and arms. I also have had 'muscle twitching in my leg muscles when lying still in bed. I have also been feeling...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...lactic acid levels, liver enzymes, and electrolyte/renal tests are useful for checking for significant metabolic problems due to mitochondrial toxicity. The rate of serious metabolic/mitochondrial toxicity on Truvada + Sustiva has been low (<... Read more »

MITOCHONDRIAL TOXICITY

I have developed myopathy due to HIV meds. Med cocktail has been change to one with minimal toxicity. In the meantime I plan to start nucleomax,coq10,lacetyl carnitine vitb1/2/6 to minimize sxs until change of meds takes effect..Are there any foods...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...aware of any particular diet that would clearly impact the course of muscle recovery from drug related injury due to presumed mitochondrial toxicity. If any reader is aware of dietary recommendations in that setting please post! KH Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?
Alvan Fisher, M.D.

Response from Alvan Fisher, M.D.

Brown University School of Medicine
No, not routinely.Alvan Fisher, M.D. Read more »
Articles
The Body

The Dangers of Mitochondrial Toxicity: An Update From the 1st International Workshop on HIV & Aging

...the nucleoside analog class of antiretrovirals, which includes Retrovir (zidovudine, AZT) and Zerit (stavudine, d4T), cause mitochondrial toxicity that is associated with subcutaneous fat loss (lipoatrophy), muscle weakness (myopathy), and... Read more »
Project Inform

Mitochondrial Toxicity and Lactic Acidosis Fact Sheet

...this enzyme synergistically (where 1+1 = more than 2). At least one group of researchers claims d4T is most commonly related to mitochondrial damage in people, though others do not accept this finding. Early results from a small study show that... Read more »
Women Alive

Mitochondrial Toxicity

...gradual break-down of the mitochondria. When the mitochondria stop performing, many illnesses can arise. This is what is called mitochondrial toxicity. Some diseases related to mitochondrial dysfunction are lactic acidosis, neuropathy, muscle... Read more »
The Body PRO

Mitochondrial Toxicity

Mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy (Poster, TuPpB1232) Authored by B.T. Roge, J. Calbet, K. Muller, H. Ullum, H.W. Hendel, J. Gerstoft, B.K. Pedersen, B. Saltin Screening for... Read more »
Connect With Others

FYI: Sustiva in Atripla. . .

Posted by razzmaniac, 1 Reply
I am not a doctor BUT i do PLENTY of research on certain meds as I have been taking meds for over 10 years. Atripla is very potent in fighting HIV virus HOWEVER. . .it contains Sustiva which in quite a few recent studies in Europe, Canada and now... Read more »

Neropathy

Posted by Anonymous, 2 Replies
Hello! I'm a 40 yro, hispanic gay male that recenly come down with a case of neropathy -nerve and shock through out my 10 toes..Ouch! I have trouble walking because my toes are so numb that I'm scared that they may crack or fall off--being unable to... Read more »

What do you think?

Posted by Anonymous, 2 Replies
Researchers Find AIDS Drugs Cause T Cell Death in Healthy, HIV Negative Patients! In the June 2, 2002 issue of Journal of Virology, researchers report an astounding... Read more »

BOYCOTT Project (RED) Auction Sothebys

Posted by Alex1, 2 Replies
SEE RED & BOYCOTT Project (RED) Auction Sothebys New York 14th February 2008 "An error can never become true however many times you repeat it. " Mahatma Gandhi (1869 - 1948). We are calling upon Bono of The (Project) Red Campaign, Damien... Read more »