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What Is Hydroxyurea

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AIDS InfoNet

Hydroxyurea (Hydrea)

What Is Hydroxyurea? Hydroxyurea (Hydrea) is a drug that was tested as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. Hydroxyurea is sometimes referred to as HU. Hydroxyurea was approved for use against cancer. It also works against sickle cell anemia. Hydroxyurea has not been approved by the FDA for use against HIV. Hydroxyurea blocks an enzyme produced by human cells. This enzyme makes building blocks used...
Ask the Experts

Hydroxyurea & children

Is Hydroxyurea now being given to pediatric patients? If so, please tell me is this still experimental? ...
Katherine Luzuriaga, M.D.

Response from Katherine Luzuriaga, M.D.

University of Massachusetts, Medical School
Hydroxyurea has been used in children, but there are few formal studies. A pilot study of hydroxyurea in combination with stavudine and ddI has recently been published (Kline et al, Pilot study of hydroxyurea in human immunodeficiency virus-infected... Read more »

Hydroxyurea, maybe or no?

Dr. Young,What do you know of Hydroxyurea?Jose...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hydroxyrea has been used in the past as an adjunct to HIV therapies that contained didanosine (ddI, Videx). Because of seriously increased toxicities, this combination should not be used.... Read more »


is hydroxyurea still a viable therapy nowadays for acute or chronic hiv treatment? How about IL-2?...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
The blush has left the rose for hydroxyurea. Clinical trials and experience demonstrate that the drug adds little to other HIV therapies and adds toxicity. IL-2 has been studied for a long time now and it is still unclear how this will fit in as... Read more »

Ok to continue with hydroxyurea?

Hello. Is hydroxyurea so bad that its benefit is outweighed by its potential for harm??? My current HIV med regimen is composed of d4t, 3tc, and hydroxyurea. I've been taking this regimen on and off for more than a year. My viral load is...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
Well, another controversy in our field.It is clear the hydroxyurea has a pro and a con. On the pro side, we do have information to show us it can boost the potency of some of our nucleoside antivirals. We just presented a study, for example, of... Read more »
Connect With Others


Posted by Anonymous, 2 Replies
I'm looking to hear from someone who has tried this hyroxyurea. My doctor wants me to try it in combination with other drugs. ANyone out there with exprience?

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Dry Mouth

Posted by Anonymous, 1 Reply
Does anyone have a treatment/advice when the combination of ddI and hydroxyurea makes my mouth bone dry and has dropped my blood platelets? Am beginning to find this worrying and uncomfortable. And am a little scared. Please help if you have an idea... Read more »

loooking for a good doctor

Posted by Anonymous
HIV Poz gay man moving to Atlanta looking for a good doc. Six years poz and very healthy; taking two protease inhibitors, an antiviral and hydroxyurea. Wanna make sure the viral load stays undetectable. Any suggestions will be greatly appreciated!

Ra... Read more »

Bristol Myers Squibbs: Videx

Posted by Anonymous, 2 Replies
Stay away from Videx it infected my pancreas and made me diabetic, apprantly it does that to a high percentage of people on it or as I also understand kills another hign percentage of them. What does Bristol Myers Squibbs do? Sell death... Read more »