What Is Drug Resistant Hiv Salvage Therapy

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Salvage Therapy

What Is Salvage Therapy? Antiretroviral therapy (ART) sometimes needs to be changed if the treatment is not working. This usually happens when the HIV viral load (see Fact Sheet 125 ) rises instead of staying very low. A rise in viral load almost always means that HIV has developed resistance (see Fact Sheet 126 ) to the antiretroviral drugs (ARVs) someone is taking. When HIV begins to increase even when someone is taking ART, this is known as...

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salvage therapy

I am a doctor based in zambia who treats HIV pateints and i have been placed in a quagmire of sorts. i recently saw ayoung man of 15 years age who is on ARV for close to 10 years. he unfortunately is resistant to a whole range of drugs . he had both...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

This is a difficult situation that is increasingly common in resource poor settings. This young man has had more access to ART and diagnostic tests than most, but the information may well be incomplete and out of date by this time. Complex... Read more »

salvage therapy

Dear Sir: I have doubts in the management of an AIDS patient. She is a 41 yo patient who is HCV and HIV (+) since 1995, having used many antiretroviral drugs in the last years.At this moment she presents a multidrug...

Response from Sharon Lee, M.D.

University of Kansas Medical Center

This patient has a very difficult resistance pattern to work around. She has lost the non-nucleoside class with the K103 and L100 mutations, knocked out zidovudine and stavudine with the 210 and 215, and of course lamivudine and emticitabine with... Read more »

Salvage Therapy Please Help

What salvage treatments can be started for a patient with Cryptococcal meningitis, CD4s of 8, a Viral Load over 100,000, off therapy for six months because of wasting that may have been caused by meds?weight returned from about 129lbs. to 160lb...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

There are two inter-related aspects to consider in your situation. The first is management of refractory cryptococcal meningitis and the second is management of drug-resistant HIV. When the HIV infection is brought under control this usually leads... Read more »

Salvage therapy choice

Hello,I was diagnosed 3/96 with AIDS (12 CD4 cells >750,000 VL). In the years since I've taken most of the HIV meds on the market. My CD4 count on 7/25 was 435 (down from 495 in April - still at 21%), and VL is 18,300, up from 11,280. My...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

Thank you for a fine description of a complicated history. I am sure that your physician and consultants have been assisted by this orderly presentation of a great deal of data.I will make the following disclaimer happily: I spent 25 years at Cook... Read more »

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Resistant, then what? How many lines of therapy?

Posted by Anonymous, 3 Replies

What percentage of folks infected with HIV are basically screwed by total resistance right out of the gate? I know resistance forms of HIV is becoming more common, but generally there is still a line of treatment options that will work for these... Read more »

Changing drug therapy

Posted by Anonymous, 1 Reply

I have been HIV+ for 12+ years and have never had a T4 count above 400 and have been as low as 128. I have never had any oportunistic infection or HIV related illness.
Current treatment includes Combivir & Crixivan. Current viral load 2043 and... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Drug Resistant HIV

Posted by Anonymous

Hi

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

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