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What Is D4T

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AIDSinfo

An Overview of Zerit (Stavudine, d4T)

STAV-yoo-deen Brand Name: Zerit Other Name: d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Approved Use: Treatment of HIV Infection WARNING: Stavudine can cause serious, life-threatening side effects. These include lactic acidosis (build up of acid in the blood), liver problems, and pancreatitis (inflammation of the pancreas). Contact your health care provider right away if you have any of the...
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Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God bless. ...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, there's no particular reason why the two drugs couldn't be... Read more »

Combining Lipitor and d4t/3tc?

I take the following throughout the day:7:30A Crix11:30A d4t/3tc3:30P Crix6:00P Lipitor11:30P Crix/d4t/3tcMy question is, can I combine my Lipitor with the 11:30A d4t/3tc dose?Thanks for your thoughts.S in Los Angeles...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
Many cholesterol lowering statins are supposed to be taken in the evening. The logic for this is that the enzyme they inhibit, HMGCoA, does most of its work at night synthesizing cholesterol. The manufacturer of lipitor does not push this as an... Read more »

D4T & Viramune?

I am building a resistance to combivar. I have been on AZT since it first came out in the late 80's. Mr Dr. is suggesting a switch to D4T and Viramune. I am concerned about the lipodystrophy factors with D4t. Any other combinations you would...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
Well, it is not settled that stavudine (d4T) is the responsible agent for lipodystrophy, in fact studies clearly show that it can happen with ALL of the other antiretroviral drugs used. In fact, one recent study, the HOPS study, found that... Read more »

What can I switch to after stopping d4t

Hi there,I have been on stavudine,lamuvidine and efavirenz for the past 4 yrs and have noticed that I have lost fat on my arms,legs and accumulated fat on my stomach,I am thinking of switching the d4t and wonder what is the best nucleoside analog...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
When a patient is experiencing fat loss on D4T then the situation may be stabilized by switching to a non-thymidine analogue such as abacavir or tenofovir. Stabilizaton or reversal is not guaranteed and may be slow to observe (the worse the fat loss... Read more »
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Need Help

Posted by Anonymous, 2 Replies
My friend has taken Stavudine, Lamivudine and Nevirapine for a month. At the end of the month her Doctor found in a Blood test increased SGPT (550 U/L), SGOT (310 U/L) and Alkaline Phosphatase (1080 U/L).
In two days after a repeated test the... Read more »

My chin and body are horrid, HELP!

Posted by Jaz, 2 Replies
Anyone have advice to make me feel better. Have been taking d4t and my chin is so large and my face round, my stomach and abdomen getting larger. Feel so depressed. Doc says can't get rid of it. Can't change meds as this the only one I can... Read more »

pregnancy and HIV

Posted by footeard, 1 Reply
Hi, I have been positive since 1987 and my husband is negative. I am 30 years old. We will be trying to concieve and have a baby in July. I am currently on D4T, Viramune and DDI. I was on AZT monotherapy from 92-94 at 300 mg a day so likely am... Read more »

Does changing cocktails help?

Posted by Anonymous, 1 Reply
I've been on the same cocktail for over 3 years
now:Crixivan, Delaverdine (sp?), & Viracept (Tried,
d4t, 3tc, ddi & ddc..major neuropathy problems. Azt
made me vrey sick!). I've had below 50 copies viral
load for 3 years (the old... Read more »