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What Is D4T

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AIDSinfo

An Overview of Zerit (Stavudine, d4T)

... STAV-yoo-deen Brand Name: Zerit Other Name(s): BMY-27857, Estavudina, d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Stavudine, also known as Zerit or d4T, is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). Stavudine works by disrupting one of the early steps in the HIV life cycle, called reverse transcription. During normal
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Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God bless.
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, Read more »

Switching from 3TC &D4T to Combivir 2

Thank for your answer Dr. Henry.I'm talking about switching to Combivir not from.Is it make sense to change Zerit and Epivir to Combivir?
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...If a patient is having problems with D4T + 3TC (such as fat problem including fat loss) then often not much is gained by switching to AZT + 3TC (Combivir). More often Read more »

DDI or D4T

Hi, I was on d4t for five months and it started giving me tingling/hypersensitive to touch feet. My doc wanted to change to DDI. Is it a good idea, i understand DDI has the same effect as D4t?
Judith A. Aberg, M.D.

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine
...Both D4T and DDI can cause peripheral neuropathy. I have had some patients that appear more sensitive to one nucleoside over the other Read more »

D4T & Viramune?

I am building a resistance to combivar. I have been on AZT since it first came out in the late 80's. Mr Dr. is suggesting a switch to D4T and Viramune. I am concerned about the lipodystrophy factors with D4t. Any other combinations you would...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
...Well, it is not settled that stavudine (d4T) is the responsible agent for lipodystrophy, in fact studies clearly show that it can happen with ALL of the other antiretroviral Read more »
Articles
The Body PRO

Session 50, Abstract 377: d4T+3TC versus AZT+3TC

... Shattering the synergy story A number of trials showed that the combination of d4T+3TC is at least aseffective as AZT+3TC, suggesting that d4T may be more attractive than AZT aspart of a combination therapy regimen Read more »
The Body PRO

Session 84, Abstract 661: A Randomized Double-Blind Study of d4T + ddI versus ZDV + ddI as Initial Treatment in Subjects with CD4 Count 3

...In this study by Fisher, et al., 137 treatment-na├»ve patients with fewer than 500 T-cells were randomized to receive either d4T+ddI or AZT+ddI to determine tolerability and antiretroviral effect. The poster presented in Chicago showed data on... Read more »
The Body PRO

For Potency Tenofovir Equals d4T but Tenofovir Beats d4T With Less Frequent and Common Side Effects

... Favorable Metabolic Profile for Tenofovir Disoproxil Fumarate (TDF) Versus Stavudine (d4T) When Used in Combination With Lamivudine and Efavirenz in Antiretroviral-Naive Patients: 96-Week Interim Results (Poster 562) Read more »
The Body PRO

Efavirenz (EFV) in Combination with Stavudine (D4T) and Didanosine (DDI) or Lamivudine (3TC) Is Well-Tolerated and Efficacious in the Majority of Patients Treated

...also called Sustiva. The original study used AZT plus 3TC -- here the investigators studied Sustiva in combination with either d4T plus 3TC, as well as d4T with ddI. Both studies enrolled just over 60 people. The d4T/3TC study presented data... Read more »
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Sustiva or DDI/hydroxurea

Posted by Anonymous, 2 Replies
...lipodystrophy but I felt perfectly okay on them. I also get agitated and upset real easily. Also, what about the combination of D4T, DDI and hydroxurea? Is that a potent combination if the Sustiva/D4T and 3TC combo I am on now doesn't make me... Read more »

signs of lipodystrophy

Posted by Anonymous
... that's just a matter of time. I stopped taking my PI's starting on Systeva/Hydrea/DDI and D4T. Does anyone have any secrets on what to do? This whole scene is about to ruin my life. Thanks Read more »

Neuropathy

Posted by Anonymous
...I had very painful neuropathy in my legs and my feet burned like I was walking on hot coals. I stopped taking the D4T and I read about a natural amino acid called Acetyl-L Carnitine (1,000mg per day) and to my surprise it worked right away. I Read more »

i am one of the "lucky"

Posted by Anonymous
... the 'lucky' few who had to find out! I tested positive in fall 96 and now, since being on a cocktail of d4t/3tc/viramune since winter 96, am undetectable ( in the above 40% range). having done... Read more »